Dystrophin-related protein in the fetal and denervated skeletal muscles of normal and mdx mice.

abstract：:We have selected calcium ionophore (A23187)-resistant cells (AR-7) in a human promyelocytic leukemia cell line, HL-60. AR-7 showed approximately 8.5-fold resistance to A23187 compared with the wild type cells after continuous exposure for 3 days. AR-7 had cross resistance to ionomycin (4.6-fold) and thapsigargin (340-...

journal_title：Biochemical and biophysical research communications

authors： Kubota M,Kataoka A,Okuda A,Bessho R,Lin YW,Wakazono Y,Usami I,Akiyama Y,Furusho K

更新日期：1995-08-15 00:00:00

abstract：:Laminin is a potent stimulator of neurite outgrowth in rat pheochromocytoma (PC12) cells. Here, we investigated the role of protein kinase C (PKC) in the mechanism of laminin-mediated neurite outgrowth in PC12 cells. Phorbol ester activators of PKC have been shown to have divergent effects on laminin-mediated neurite ...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Wilson PJ,Heffernan CC,Ahmad A,Mahadeo K

更新日期：1999-03-05 00:00:00

abstract：:Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recen...

journal_title：Biochemical and biophysical research communications

authors： Sonobe Y,Liang J,Jin S,Zhang G,Takeuchi H,Mizuno T,Suzumura A

更新日期：2008-05-23 00:00:00

abstract：:We previously reported that Ca2+/calmodulin-dependent protein kinase II (CaMKII) is inhibited by S-nitrosylation of Cys6 in cells. Herein, we show that polysulfidation of CaMKII at Cys6 limits its enzyme activity following reactive sulfur species (RSS) stimulus. In vitro incubation of CaMKII with the RSS donor, Na2S4,...

journal_title：Biochemical and biophysical research communications

authors： Araki S,Takata T,Tsuchiya Y,Watanabe Y

更新日期：2019-01-08 00:00:00

abstract：:A 2.1-kb genomic region responsible for Ogawa serotype specificity of Vibrio cholerae 01 was identified by cosmid cloning and recombinant plasmid experiments. The plasmid carrying this region derived from Ogawa type Vibrio cholerae NIH 41 coded for a specific protein of 27 kD, and was found to convert serotype specifi...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Ohshita Y,Nakamoto T,Hiramatsu K,Yokota T

更新日期：1991-03-15 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:Dickkopf-1 (DKK-1) is known inhibitor of the canonical Wnt pathway. Recent studies strongly suggested that activation of DKK-1 expression results in inhibition of cell tumorigenicity. Reduced levels of DKK-1 in melanomas were recently shown. However, it is not known if DKK-1 activation in melanoma cells will inhibit c...

journal_title：Biochemical and biophysical research communications

authors： Mikheev AM,Mikheeva SA,Rostomily R,Zarbl H

更新日期：2007-01-19 00:00:00

abstract：:In this work, we show that glucose-induced activation of plasma membrane H(+)-ATPase from Saccharomyces cerevisiae is strongly dependent on calcium metabolism and that the glucose sensor Snf3p works in a parallel way with the G protein Gpa2p in the control of the pathway. The role of Snf3p is played by the Snf3p C-ter...

journal_title：Biochemical and biophysical research communications

authors： Trópia MJ,Cardoso AS,Tisi R,Fietto LG,Fietto JL,Martegani E,Castro IM,Brandão RL

更新日期：2006-05-19 00:00:00

abstract：:Transformation of fluorene by washed cells of fluorene-grown Pseudomonas sp. F274 yielded 1,la-dihydroxy-1-hydrofluoren-9-one (up to 100 mg/l) as the stable product of angular dioxygenation of 9-fluorenone. Structural identity of the angular keto-diol was established by 13C- and 1H-NMR, gas chromatography- and direct ...

journal_title：Biochemical and biophysical research communications

authors： Selifonov SA,Grifoll M,Gurst JE,Chapman PJ

更新日期：1993-05-28 00:00:00

abstract：:Thaumatin-like proteins (TLPs) are found in diverse eukaryotes. Plant TLPs, known as Pathogenicity Related Protein (PR-5), are considered fungal inhibitors. However, genes encoding TLPs are frequently found in fungal genomes. In this work, we have identified that Moniliophthora perniciosa, a basidiomycete pathogen tha...

journal_title：Biochemical and biophysical research communications

authors： Franco Sde F,Baroni RM,Carazzolle MF,Teixeira PJ,Reis O,Pereira GA,Mondego JM

更新日期：2015-10-30 00:00:00

abstract：:Previously, we showed that several minor macromolecular glycolipids accounting for less than 5% of the lipoteichoic acid (LTA) fraction from Enterococcus hirae ATCC 9790 possess cytokine-inducing activity, whereas the purified LTA does not. In other words, the immunobiological activity of the LTA fraction reported in ...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Imamura Y,Morichika T,Arimoto K,Takeuchi O,Takeda K,Akira S,Aoyama K,Tamura T,Kotani S,Suda Y,Kusumoto S

更新日期：2000-06-24 00:00:00

abstract：:A gene library of Anaerocellum thermophilum Z-1320 was constructed in Escherichia coli using plasmid pUC18. Clones were selected by screening for hydrolysis of CMC, MU-Cel, lichenan and xylan. Recombinant clones expressing two beta-1,4-glucanases and two different xylanases were obtained. Both beta-1,4-glucanases were...

journal_title：Biochemical and biophysical research communications

authors： Bolshakova EV,Ponomariev AA,Novikov AA,Svetlichnyi VA,Velikodvorskaya GA

更新日期：1994-07-29 00:00:00

abstract：:Angiotensin II (Ang-II) has been shown to possess several atherogenic properties including its ability to induce macrophage-mediated oxidation of LDL and to form Ang-II-modified LDL which is taken up by macrophages at enhanced rate. Oxidized-LDL (Ox-LDL) is also taken up by macrophages at enhanced rate via several sca...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J

更新日期：1997-10-09 00:00:00

abstract：:The C-terminal alpha-amide formation of the peptides is one of the most important events of prohormone processing. We have recently isolated an alpha-amidating enzyme, AE-I, from Xenopus laevis skin, which is the only enzyme ever purified to homogeneity. In this study, we report cloning and sequence of cDNA encoding A...

journal_title：Biochemical and biophysical research communications

authors： Mizuno K,Ohsuye K,Wada Y,Fuchimura K,Tanaka S,Matsuo H

更新日期：1987-10-29 00:00:00

abstract：:We have previously shown that the protein encoded by a human insulin-like growth factor I (IGF-I) receptor cDNA binds both IGF-I and II with high affinity. In the present studies, we show that a monoclonal antibody to the IGF-I receptor, alpha IR-3, inhibits the binding of IGF-I but not IGF-II to the expressed recepto...

journal_title：Biochemical and biophysical research communications

authors： Steele-Perkins G,Roth RA

更新日期：1990-09-28 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi's sarcoma-associated herpesvirus (KSHV). This study provides evidence that proteasomal activity is required for both survival of PEL cells stably harboring the KSHV genome and viral replication of KSHV. We evaluated the cytotoxic effects of pro...

journal_title：Biochemical and biophysical research communications

authors： Saji C,Higashi C,Niinaka Y,Yamada K,Noguchi K,Fujimuro M

更新日期：2011-12-02 00:00:00

abstract：:It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles...

journal_title：Biochemical and biophysical research communications

authors： Chen F

更新日期：2005-06-24 00:00:00

abstract：:Cytoplasmic polyadenylation element binding (CPEB) proteins are RNA-binding proteins involved in translational regulation of the specific target mRNAs and control function of various organs including brain, liver and hematopoietic system. However, the role of CPEB proteins during osteoclast differentiation remains unc...

journal_title：Biochemical and biophysical research communications

authors： Arasaki Y,Li M,Akiya T,Nozawa I,Ezura Y,Hayata T

更新日期：2020-08-06 00:00:00

abstract：:Neuregulins comprise a group of growth factor proteins that regulate the differentiation of skeletal muscle. Here, we report that neuregulins are regulators of myogenic differentiation and stimulate mitogenesis in L6 skeletal myoblasts. The mitogenic response to neuregulin-1 was differentiation-dependent and observed ...

journal_title：Biochemical and biophysical research communications

authors： Ford BD,Han B,Fischbach GD

更新日期：2003-06-20 00:00:00

abstract：:Manganese (Mn) is required in various human physiological processes. Excessive Mn exposure causes manganism, a progressive neurodegenerative disorder similar to idiopathic Parkinson's disease (IPD). However, the detailed mechanism of Mn-induced neurotoxicity is not yet fully understood. MicroRNAs (miRNAs) play importa...

journal_title：Biochemical and biophysical research communications

authors： He R,Xie X,Lv L,Huang Y,Xia X,Chen X,Zhang L

更新日期：2017-04-29 00:00:00

abstract：:Fluid flowing through the bone porosity might be a primary stimulus for functional adaptation of bone. Osteoblasts, and osteocytes in particular, respond to fluid flow in vitro with enhanced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) release; both of these signaling molecules mediate mechanically-induced bone f...

journal_title：Biochemical and biophysical research communications

authors： McGarry JG,Klein-Nulend J,Prendergast PJ

更新日期：2005-04-29 00:00:00

abstract：:Inhibitors of serine/threonine protein phosphatases can inhibit apoptosis. We investigated which protein phosphatases are critical for this protection using calyculin A, okadaic acid, and tautomycin. All three phosphatase inhibitors prevented anisomycin-induced apoptosis in leukemia cell models. In vitro, calyculin A ...

journal_title：Biochemical and biophysical research communications

authors： Chatfield K,Eastman A

更新日期：2004-10-29 00:00:00

abstract：:The optical spectrum of Sperm Whale myoglobin, which has been freshly reconstituted with iron protoporphyrin-IX, is shown to be different from that obtained from the native myoglobin, and from the reconstituted, incubated myoglobin (These last two have equivalent absorption spectra). The effect is immediately evident ...

journal_title：Biochemical and biophysical research communications

authors： Gebe JA,Peyton DH,Peyton JA

更新日期：1989-05-30 00:00:00

abstract：:By constructing a new type of thermal detector, rapid production of heat was demonstrated during the rising phase of the action potential of the eel electric organs evoked by direct electric stimulation. Following the indirect (synapse-mediated) action potential of the organs, the existence of very large and variable ...

journal_title：Biochemical and biophysical research communications

authors： Tasaki I,Byrne PM

更新日期：1993-12-15 00:00:00

abstract：:Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified comet assay to determine the effect of these metabolites on ba...

journal_title：Biochemical and biophysical research communications

authors： van Dyk E,Steenkamp A,Koekemoer G,Pretorius PJ

更新日期：2010-10-08 00:00:00

abstract：:We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during megakaryocytic differentiation of K562 cells induced by PMA. Northern blot and reverse transcription polymerase chain reaction (RT-PCR) indicated that the induction of hST3Gal V by phorbol 12-myristate 13-acetate (PMA) is regulated at t...

journal_title：Biochemical and biophysical research communications

authors： Choi HJ,Chung TW,Kang NY,Kim KS,Lee YC,Kim CH

更新日期：2004-01-02 00:00:00

abstract：:Clones of eukaryotic initiation factor (eIF) 4B from wheat and Arabidopsis thaliana were obtained from cDNA and genomic libraries. The exon/intron organization of the genes from wheat and A. thaliana is very similar. The deduced amino acid sequences for the wheat and Arabidopsis eIF4B proteins showed overall similarit...

journal_title：Biochemical and biophysical research communications

authors： Metz AM,Wong KC,Malmström SA,Browning KS

更新日期：1999-12-20 00:00:00

abstract：:Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus. In this study, we generated three human anti...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Takemura H,Suzuki M,Sekine Y,Kashiwagi H

更新日期：1997-03-06 00:00:00

abstract：:Glycerol-3-phosphate acyltransferase, mitochondrial (GPAM) is a rate-limiting enzyme catalyzing triglyceride synthesis. Recently, we demonstrated that the anti-viral drug ribavirin (RBV) reduces GPAM expression by downregulating CCAAT/enhancer-binding protein α (C/EBPα). However, the precise mechanisms of GPAM suppres...

journal_title：Biochemical and biophysical research communications

authors： Onomura D,Satoh S,Ueda Y,Dansako H,Kato N

更新日期：2020-11-26 00:00:00

abstract：:Upregulation of insulin-like growth factor (IGF)-II expression has been reported for a variety of childhood and adulthood tumors. We determined IGF-II gene promoter usage in human cancerous and benign tissues by semiquantitative RT-PCR using P1-P4-specific primers. Although the human IGF-II gene structure is commonly ...

journal_title：Biochemical and biophysical research communications

authors： Mineo R,Fichera E,Liang SJ,Fujita-Yamaguchi Y

更新日期：2000-02-24 00:00:00