Rapid heat production associated with excitation of electric organs of the electric eel.

abstract：:Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating ...

journal_title：Biochemical and biophysical research communications

authors： Duarte M,Kolev V,Soldi R,Kirov A,Graziani I,Oliveira SM,Kacer D,Friesel R,Maciag T,Prudovsky I

更新日期：2006-11-24 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is featured by hepatic steatosis, insulin resistance, lipid deposition and inflammation. However, the pathogenic mechanism of NAFLD is still poorly understood. Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negativ...

journal_title：Biochemical and biophysical research communications

authors： Wu YK,Hu LF,Lou DS,Wang BC,Tan J

更新日期：2020-03-26 00:00:00

abstract：:Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre. The initial iodine content of the protein (0.038%) has been increased to levels of 0.16% and 0.85% by in vitro treatment with thyroid peroxidase and the resulting proteins studied with respect to their intrinsic fluorescen...

journal_title：Biochemical and biophysical research communications

authors： Zabel KM,Rawitch AB

更新日期：1984-05-31 00:00:00

abstract：:An orphan G protein-coupled receptor, termed 6H1, with approximately 30% sequence identity to P2Y receptors has been proposed to be a P2Y receptor (p2y5) based solely on a radioligand binding assay with [35S]dATP alphaS [Webb et al. (1997) Biochem. Biophys. Res. Commun. 219:105-110]. Previous work in our laboratory ha...

journal_title：Biochemical and biophysical research communications

authors： Li Q,Schachter JB,Harden TK,Nicholas RA

更新日期：1997-07-18 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:This study investigates whether angiotensin converting enzyme (ACE) inhibitors can block high glucose-induced increase of angiotensin II (Ang II) levels in cultured rat mesangial cells. Incubation of cells with high glucose for 5 days increased Ang II in the cell media (extracellular) and cell lysates (intracellular) ...

journal_title：Biochemical and biophysical research communications

authors： Singh R,Leehey DJ

更新日期：2007-06-15 00:00:00

abstract：:A new eukaryotic initiation factor 2 kinase has been purified for the first time from calf brain cytosol. The purification of a nonabundant novel protein kinase activity, designated as PKI, that phosphorylates the alpha subunit of eukaryotic initiation factor 2 is described. The protein kinase activity was assayed usi...

journal_title：Biochemical and biophysical research communications

authors： Alcázar A,Méndez E,Martín ME,Salinas M

更新日期：1990-02-14 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

更新日期：2014-05-10 00:00:00

abstract：:In epithelial cells progression through the G1 phase of the cell cycle and preparing the cell for the S phase is regulated by cyclin D1-cdk4. Cells that express the retinoblastoma protein (pRb) are dependent on cyclin D1-cdk4 activity for their proliferation while cells that do not express pRb are not. Overexpression ...

journal_title：Biochemical and biophysical research communications

authors： Kent LL,Hull-Campbell NE,Lau T,Wu JC,Thompson SA,Nori M

更新日期：1999-07-14 00:00:00

abstract：:Estrogen receptor (ER) is regarded as a major causal factor in breast cancer and FoxA1, a winged-helix transcription factor belonging to the forkhead family, has been found to function as a pioneer factor in the recruitment of ER to several cis-regulatory elements in the genome. High throughput chromatin immunoprecipi...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Chen S

更新日期：2010-09-10 00:00:00

abstract：:We showed previously that the neuropeptide, galanin, transiently and promptly increases the cytoplasmic concentration of Ca2+, [Ca2+]i, in insulin producing clonal RINm5F cells prior to a reduction in [Ca2+]i. We found that galanin (100 nM) transiently increased the [Ca2+]i in the presence of 15 mM glyceraldehyde and ...

journal_title：Biochemical and biophysical research communications

authors： Ahrén B

更新日期：1996-04-05 00:00:00

abstract：:The ras family of oncogenes, as well as the transplasma membrane electron transport system, have been implicated in cellular growth control. Here we present evidence that the Ha-ras oncoprotein increases the activity of the transplasma membrane electron transport system in the mouse embryonic fibroblast cell line C3H1...

journal_title：Biochemical and biophysical research communications

authors： Crowe RA,Taparowsky EJ,Crane FL

更新日期：1993-10-29 00:00:00

abstract：:Serum leptin levels are elevated in subjects with exogenous obesity, indicating that obesity is associated with leptin resistance. Since in man no abnormalities have yet been found in either the genes for leptin or its receptor, the mechanism of leptin resistance in obesity remains unknown. To determine if resistance ...

journal_title：Biochemical and biophysical research communications

authors： Diamond FB Jr,Eichler DC,Duckett G,Jorgensen EV,Shulman D,Root AW

更新日期：1997-04-28 00:00:00

abstract：:Autophagy is a physiologically regulated and evolutionary conserved process that plays a critical role in degradation of cytoplasmic proteins and other macromolecules within the lysosomes. Beclin-1, the mammalian orthologue of yeast Atg6, is an important mediator of autophagy that has been studied in many human cancer...

journal_title：Biochemical and biophysical research communications

authors： Kapoor V,Paliwal D,Baskar Singh S,Mohanti BK,Das SN

更新日期：2012-06-15 00:00:00

abstract：:In the central nervous system of 11.5-day mouse embryos, the expression of CRABP was spatially restricted to the anteroposterior axis. CRABP was most strongly expressed in the rhombencephalon and the anterior part of the neural tube. In 14-day mouse embryo, CRABP drastically decreased in the brain and the anterior par...

journal_title：Biochemical and biophysical research communications

authors： Momoi T,Hanaoka K,Momoi M

更新日期：1990-06-29 00:00:00

abstract：:Activities of the hepadnavirus polymerases are known to include those of DNA polymerase, reverse transcriptase and RNase H. To date, it has been difficult or impossible to clone and express the product as an active enzyme. In this study, full length capped RNA encoding Duck Hepatitis B Virus (DHBV) polymerase was prod...

journal_title：Biochemical and biophysical research communications

authors： Howe AY,Elliott JF,Tyrrell DL

更新日期：1992-12-15 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is periodically administered to immunocompromised patients together with antimicrobial agents. The evidence that supports the effectiveness of IVIG is mostly based on data from randomized clinical trials; the underlying mechanisms are poorly understood. A recent study revealed that ki...

journal_title：Biochemical and biophysical research communications

authors： Matsuo H,Itoh H,Kitamura N,Kamikubo Y,Higuchi T,Shiga S,Ichiyama S,Kondo T,Takaori-Kondo A,Adachi S

更新日期：2015-08-14 00:00:00

abstract：:Hartnup disorder is an autosomal recessive phenotype involving a transporter for monoamino-monocarboxylic acids. Genetic analysis of the mouse model mapped its locus to human chromosome 11q13 (8). We report here the results of linkage analysis in two Japanese first cousin-marriage families. In the first family, the pr...

journal_title：Biochemical and biophysical research communications

authors： Nozaki J,Dakeishi M,Ohura T,Inoue K,Manabe M,Wada Y,Koizumi A

更新日期：2001-06-08 00:00:00

abstract：:A two fold stimulation in the incorporation of [3H-methyl] groups from [3H-methyl] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release. Nonstimulatory sugars, L-glucose and D-galactose, as well as dibutyryl cAMP, d...

journal_title：Biochemical and biophysical research communications

authors： Kowluru A,Rana RS,MacDonald MJ

更新日期：1984-07-31 00:00:00

abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

journal_title：Biochemical and biophysical research communications

authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

更新日期：1999-09-07 00:00:00

abstract：:Mutant superoxide dismutase 1 (mSOD1) is often found as aggregates at the outer-membrane of mitochondria in motor neurons of various mouse models and familial amyotrophic lateral sclerosis (f-ALS) patients. It has been postulated that disruption of mitochondrial function by physical association of misfolded mSOD1 aggr...

journal_title：Biochemical and biophysical research communications

authors： Wei R,Bhattacharya A,Chintalaramulu N,Jernigan AL,Liu Y,Van Remmen H,Chaudhuri AR

更新日期：2012-01-27 00:00:00

abstract：:Saccharides used in clinical nutrients and the hyperglycemia status may facilitate tumor growth and aggravate cancer patients' outcome. As glucose, fructose and maltodextrin are widely used in clinical practice, various effects on tumor progress among them remain unknown. Six kinds of tumor cell lines were included in...

journal_title：Biochemical and biophysical research communications

authors： Yu C,Lv B,Min S,Ren L,Yu J

更新日期：2020-05-07 00:00:00

abstract：:Trypsin-like serine proteases are involved in diverse biological processes such as complement activation, tissue remodeling, cellular migration, tumor invasion, and metastasis. Here we report a novel human C1r-like serine protease analog, CLSPa, derived from dendritic cells (DC). The 487-residue CLSPa protein contains...

journal_title：Biochemical and biophysical research communications

authors： Lin N,Liu S,Li N,Wu P,An H,Yu Y,Wan T,Cao X

更新日期：2004-08-20 00:00:00

abstract：:A novel assay for selective determination of polynucleotides using atomic force microscopy in conjunction with the formation of the probe/target/DNA-gold nanoparticle sandwich structure at a gold surface is described. A 17-mer probe was attached to the surface for subsequent hybridization with a polynucleotide target....

journal_title：Biochemical and biophysical research communications

authors： Han S,Lin J,Zhou F,Vellanoweth RL

更新日期：2000-12-09 00:00:00

abstract：:Glucocorticoid receptors (GRs) are extensively studied members of the steroid hormone receptor superfamily that regulate the transcription rates of numerous genes. Notwithstanding, the role of each GR amino acid in the various steps of transactivation is still unknown. A recent report shows that linear DNA has the sam...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Blackford JA Jr,Simons SS Jr

更新日期：2004-09-03 00:00:00

abstract：:This study evaluates the influence of vinculin in closed conformation on the mechanical properties of cells. We demonstrate that MEFvin(-/-) cells transfected with the eGFP-vinculin mutant A50I (talin-binding-deficient-vinculin in a constitutively closed conformation) show 2-fold lower stiffness and focal adhesion den...

journal_title：Biochemical and biophysical research communications

authors： Diez G,Auernheimer V,Fabry B,Goldmann WH

更新日期：2011-03-04 00:00:00

abstract：:Activation of the receptor activator of nuclear factor-κB (RANK) by its ligand (RANKL) is involved in both solid and hematological malignancies, including multiple myeloma, acute myeloid leukemia and B-cell leukemia. Although RANKL expression has been described in normal T cells, a potential role in T-cell leukemia re...

journal_title：Biochemical and biophysical research communications

authors： Fernandes MT,Caroço LS,Pacheco-Leyva I,Dos Santos NR

更新日期：2019-03-05 00:00:00

abstract：:A novel cDNA clone was identified through yeast two-hybrid experiments. Following cross-examination between the cDNA clones, EST clones, and the cosmid clone, we could digitally assemble a new zinc finger transcription factor gene. This predicted gene has a cDNA size of about 1960 bp and is translated into a 487-amino...

journal_title：Biochemical and biophysical research communications

authors： Lin W,Lai CH,Tang CJ,Huang CJ,Tang TK

更新日期：1999-11-02 00:00:00

abstract：:X-linked juvenile retinoschisis (RS) is a bilateral vitreoretinal disorder with no known cure. The gene responsible for the disease was recently isolated by positional cloning methods and a spectrum of mutations has been described in families with RS pathology. In this report, we screened six sporadic cases of RS for ...

journal_title：Biochemical and biophysical research communications

authors： Hiraoka M,Trese MT,Shastry BS

更新日期：2000-02-16 00:00:00