Abstract:
:A two fold stimulation in the incorporation of [3H-methyl] groups from [3H-methyl] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release. Nonstimulatory sugars, L-glucose and D-galactose, as well as dibutyryl cAMP, did not affect phospholipid methylation in islet cells. A calcium channel blocker, verapamil, inhibited methylation. These studies suggest that the signal for glucose-induced insulin release could involve phospholipid methylation.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kowluru A,Rana RS,MacDonald MJdoi
10.1016/s0006-291x(84)80091-1subject
Has Abstractpub_date
1984-07-31 00:00:00pages
706-11issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(84)80091-1journal_volume
122pub_type
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