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Human monoclonal antibodies produced from L-leucine methyl ester-treated and in vitro immunized peripheral blood lymphocytes.

Abstract：

:Primary in vitro immunization of peripheral blood lymphocytes has been studied for the production of human monoclonal antibodies. Depletion of a lysosome-rich cell population, containing large granular lymphocytes, monocytes, and a subset of T suppressor cells, was shown to be crucial before the cells could be immunized in vitro. The in vitro immunized lymphocytes were used to produce human x human and human x mouse hybridomas secreting monoclonal antibodies specific for digoxin, hemocyanin, or a recombinant fragment of gp120 of human immunodeficiency virus.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Borrebaeck CA,Danielsson L,Möller SA

doi

10.1016/s0006-291x(87)80223-1

subject

Has Abstract

pub_date

1987-11-13 00:00:00

pages

941-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80223-1

journal_volume

148

pub_type

杂志文章

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