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Parkinsonism-associated protein DJ-1 is a bona fide deglycase.

Abstract：

:We discovered recently that Parkinsonism-associated DJ-1 and its bacterial homologs function as protein deglycases that repair glyoxal- and methylglyoxal-glycated proteins. Protein glycation levels are 2- to 10-fold increased in deglycase-depleted cells, and deglycase mutants display up to 500-fold loss of viability in methylglyoxal or glucose-containing media, suggesting that these deglycases play important roles in protecting cells against electrophile and carbonyl stress. Although the deglycase activity of DJ-1 is well supported by extensive biochemical work, Pfaff et al. (J. Biol. Chem. in presshttp://dx.doi.org/10.1074/jbc.M116.743823) claimed in a recent study that deglycation of the hemithioacetal formed upon cysteine glycation by methylglyoxal results from a Tris buffer artefact. Here, we show that this is not the case, and that DJ-1 and its homologs are the bona fide deglycases awaited since the Maillard discovery.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Richarme G,Dairou J

doi

10.1016/j.bbrc.2016.12.134

subject

Has Abstract

pub_date

2017-01-29 00:00:00

pages

387-391

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)32194-5

journal_volume

483

pub_type

杂志文章

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