Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells.

Abstract:

:Measurements of the cytosolic calcium concentration in single cells of the clonal endocrine pancreatic glucagon-secreting cell line INR1 G9 revealed the existence of spontaneous calcium oscillations in 20-70% of these cells. Inhibition of these spontaneous oscillations by thapsigargin as well as the phospholipase C inhibitor U 73122 demonstrated involvement of calcium release from intracellular stores, probably mediated by a high basal activity of phospholipase C. Removal of extracellular calcium but not the L-type calcium channel antagonists verapamil or nifedipine terminated the spontaneous oscillations, suggesting that calcium influx by a pathway distinct from L-type channels contributed to the oscillations. Similar spontaneous calcium oscillations could be the pacemaker of pulsatile glucagon release in endocrine pancreatic A-cells.

authors

Bode HP,Yule DI,Fehmann HC,Göke B,Williams JA

doi

10.1006/bbrc.1994.2684

subject

Has Abstract

pub_date

1994-11-30 00:00:00

pages

435-40

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72684-2

journal_volume

205

pub_type

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