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Isolation and sequence of rat testis cDNA for a calcium binding polypeptide similar to the regulatory subunit of calcineurin.

Abstract：

:We have cloned and sequenced rat testis cDNAs coding for a calcium binding polypeptide similar to calcineurin beta subunit, the Ca(2+)-binding subunit of the Ca2+/calmodulin stimulated protein phosphatase. Rat testis cDNA library was screened with a monoclonal antibody Va1 raised against bovine brain calcineurin beta subunit. The deduced amino acid sequence is similar to that of human brain calcineurin beta subunit with respect to containing four putative calcium binding sites. However, distinct differences were found: 1) The cloned cDNA had six amino acids polypeptide tail at carboxy-terminal which is absent in human brain calcineurin beta subunit. This amino acids tail makes the carboxy-terminal highly hydrophilic in contrast to the human brain beta subunit which is hydrophobic at carboxy-terminal; 2) eleven amino acids at the N terminal of the cloned cDNA were completely different from the corresponding region of the brain calcineurin beta subunit.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sugimoto M,Matsui H,Etoh S,Shimizu T,Nishio H,Moia LJ,Tokuda M,Itano T,Takenaka I,Hatase O

doi

10.1016/s0006-291x(05)81362-2

subject

Has Abstract

pub_date

1991-11-14 00:00:00

pages

1476-82

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81362-2

journal_volume

180

pub_type

杂志文章

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