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Identification of initiating agents in myoglobin-induced lipid peroxidation.

Abstract：

:Reaction of metmyoglobin with peroxides is known to involve the formation, possibly via a porphyrin radical-cation, of a ferryl (iron(IV)-oxo) species and a protein radical; there is a little information available as to which of these species initiates the damage which is observed on incubating membrane fractions with such mixtures. It is shown in this study that the initial protein radical, which is a tyrosine phenoxyl radical centered at position 103 in the protein, does not react rapidly with erythrocyte membranes. However a tyrosine peroxyl radical, formed by addition of oxygen to this species, does react rapidly, and it is concluded that this radical, together with the ferryl species, is an important initiating species in myoglobin-induced lipid peroxidation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Newman ES,Rice-Evans CA,Davies MJ

doi

10.1016/0006-291x(91)91730-z

subject

Has Abstract

pub_date

1991-09-30 00:00:00

pages

1414-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91730-Z

journal_volume

179

pub_type

杂志文章

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