O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau.

abstract：:The interaction between histone H1 and non-histones HMG14 and HMG17 has been studied by chemical cross-linking. Cross-linking kinetics show the appearance of discrete bands which correspond to the interaction between H1 and HMG14. Interaction between H1 and HMG17 has not been detected. ...

journal_title：Biochemical and biophysical research communications

authors： Espel E,Bernués J,Querol E,Martínez P,Barris A,Lloberas J

更新日期：1983-12-28 00:00:00

abstract：:The status of Ca(2+)-channels and adrenoceptors in the hind leg skeletal muscle was examined in rats 8 weeks after inducing diabetes by an intravenous injection of streptozotocin (65 mg/kg). Scatchard plot analysis of the data on specific binding of 3H-nitrendipine with crude membranes from diabetic muscle revealed an...

journal_title：Biochemical and biophysical research communications

authors： Lee SL,Dhalla NS

更新日期：1992-04-15 00:00:00

abstract：:The ouabain-resistant and ouabain-sensitive alpha-subunit cRNAs in various molar ratios were injected into Xenopus oocytes together with cRNA for the beta-subunit. The ouabain-resistant ATPase activity, as well as ouabain-resistant Rb+ uptake, of the injected oocytes increased linearly with increasing the amount of cR...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Kawamura M

更新日期：2001-02-09 00:00:00

abstract：:Myocardial cells respond to changes in the mechanical forces imposed on them with changes in myocardial tension in the short term and with structural remodeling in the long term. Since these responses involve intercellular communication, we have investigated regulation of the gap junction proteins, connexin 43 (Cx43),...

journal_title：Biochemical and biophysical research communications

authors： Wang TL,Tseng YZ,Chang H

更新日期：2000-01-19 00:00:00

abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

journal_title：Biochemical and biophysical research communications

authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

更新日期：2007-11-03 00:00:00

abstract：:Epidemiological and experimental data suggest a role for polyunsaturated fatty acids in the etiology of breast cancer. In this report we have studied arachidonic acid and linoleic acid metabolism in the human breast carcinoma cell line BT-20 which overexpresses both EGF receptor and the homologous erbB-2 oncogene prod...

journal_title：Biochemical and biophysical research communications

authors： Reddy N,Everhart A,Eling T,Glasgow W

更新日期：1997-02-03 00:00:00

abstract：:Previously, we have demonstrated evidence suggesting that SUMO4 negatively regulates NFkappaB transcriptional activity, probably through sumoylation of IkappaBalpha. Here, we present data indicating that SUMO4 possesses the capacity to conjugate to IkappaBalpha. Luciferase reporter assays in 3T3 cells deficient for Ik...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Yang P,Li M,Gong F

更新日期：2009-04-17 00:00:00

abstract：:BRCT(BRCA1) plays a major role in DNA repair pathway, and does so by recognizing the conserved sequence pSXXF in its target proteins. Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity. Here, we have characterized the binding interactions of pSXXF tetrapeptides using NM...

journal_title：Biochemical and biophysical research communications

authors： Joseph PR,Yuan Z,Kumar EA,Lokesh GL,Kizhake S,Rajarathnam K,Natarajan A

更新日期：2010-03-05 00:00:00

abstract：:Apolipoprotein E-knockout (ApoE(-/-)) mice, atherosclerosis-prone mice, show an autoimmune response, but the pathogenesis is not fully understood. We investigated the pathogenesis in female and male ApoE(-/-) mice. The spleens of all ApoE(-/-) and C57BL/6 (B6) mice were weighed. The serum IgG level and titers of anti-...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang Z,Lu H,Lin H,Wang Z,Chen X,Ouyang Q,Tang M,Hao P,Ni J,Xu D,Zhang M,Zhang Q,Lin L,Zhang Y

更新日期：2012-07-13 00:00:00

abstract：:The purpose of the present study was to investigate the effect of acute exercise on lipolysis via coordination of hormone-sensitive lipase (HSL) and scaffold proteins, i.e., perilipin A and comparative gene identification-58 (CGI-58), in rat primary adipocytes. Glycerol release was significantly elevated immediately (...

journal_title：Biochemical and biophysical research communications

authors： Ogasawara J,Nomura S,Rahman N,Sakurai T,Kizaki T,Izawa T,Ishida H,Haga S,Ohno H

更新日期：2010-09-10 00:00:00

abstract：:Although oxygen levels in the extracellular space of most mammalian tissues are just a few percent, under standard cell culture conditions they are not regulated and are often substantially higher. Some cellular sources of reactive oxygen species, like NADPH oxidase 4, are sensitive to oxygen levels in the range betwe...

journal_title：Biochemical and biophysical research communications

authors： Maddalena LA,Selim SM,Fonseca J,Messner H,McGowan S,Stuart JA

更新日期：2017-11-04 00:00:00

abstract：OBJECTIVE:To evaluate protein profiles and Fc gamma receptor IIb (FCGRIIB) expression in abdominal aortic aneurysm (AAA) compared to the expression in normal aortas. METHODS:We performed a protein array to study the protein expression profiles within AAA and normal aortic tissues. FCGRIIB was found to be significantly...

journal_title：Biochemical and biophysical research communications

authors： Shi Y,Yang CQ,Wang SW,Li W,Li J,Wang SM

更新日期：2017-04-01 00:00:00

abstract：:A L-delta 1-pyrroline-5-carboxylate reductase activity has been detected in crude extracts of Desulfovibrio desulfuricans Norway. This P5C reductase activity is also found when a 2.5 kb D. desulfuricans DNA fragment is introduced into an Escherichia coli proC mutant. Although it restores growth of the proC mutant, the...

journal_title：Biochemical and biophysical research communications

authors： Fons M,Cami B,Chippaux M

更新日期：1991-09-16 00:00:00

abstract：:HIV-1 protease inhibitors are effective in HIV/AIDS therapy, although drug resistance is a severe problem. This study examines the effects of four investigational inhibitors against HIV-1 protease with drug resistant mutations of V32I, I47V and V82I (PRTri) that model the inhibitor-binding site of HIV-2 protease. Thes...

journal_title：Biochemical and biophysical research communications

authors： Pawar S,Wang YF,Wong-Sam A,Agniswamy J,Ghosh AK,Harrison RW,Weber IT

更新日期：2019-06-30 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:The formation of nitric oxide in biological systems has led to the discovery of a number of post-translational protein modifications that could regulate protein function or potentially be utilized as transducers of nitric oxide signaling. Principal among the nitric oxide-mediated protein modifications are: the nitric ...

journal_title：Biochemical and biophysical research communications

authors： Ischiropoulos H

更新日期：2003-06-06 00:00:00

abstract：:We have cloned and sequenced rat testis cDNAs coding for a calcium binding polypeptide similar to calcineurin beta subunit, the Ca(2+)-binding subunit of the Ca2+/calmodulin stimulated protein phosphatase. Rat testis cDNA library was screened with a monoclonal antibody Va1 raised against bovine brain calcineurin beta ...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto M,Matsui H,Etoh S,Shimizu T,Nishio H,Moia LJ,Tokuda M,Itano T,Takenaka I,Hatase O

更新日期：1991-11-14 00:00:00

abstract：:The p53 homologue p73 is expressed in at least six different isoforms (alpha, beta, gamma, delta, epsilon, and zeta), but unlike p53 it has rarely been found mutated in human cancers. However, altered expression of this gene has been reported in cancer cells. In order to understand if p73 is involved in normal and mal...

journal_title：Biochemical and biophysical research communications

authors： Tschan MP,Grob TJ,Peters UR,Laurenzi VD,Huegli B,Kreuzer KA,Schmidt CA,Melino G,Fey MF,Tobler A,Cajot JF

更新日期：2000-10-14 00:00:00

abstract：:Kinetic analyses were performed to understand the mechanism of hyperoxic induced inhibition of prostacyclin synthesis by human umbilical arteries. Brief exposure of arterial segments to oxygen resulted in over 30% decrease in Vmax of cyclooxygenase in treated vessels. In contrast, cyclooxygenase from hypoxic arterial ...

journal_title：Biochemical and biophysical research communications

authors： Yamaja Setty BN,Walenga RW,Stuart MJ

更新日期：1984-11-30 00:00:00

abstract：:We have analyzed heteroplasmy of mitochondrial DNA in clonal cultures from two patients with Kearns-Sayre syndrome, and have found that individual muscle or fibroblast clones contained either a mixed (i.e. heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e. homop...

journal_title：Biochemical and biophysical research communications

authors： Moraes CT,Schon EA,DiMauro S,Miranda AF

更新日期：1989-04-28 00:00:00

abstract：:Secreted gelatinase from human neutrophils was purified as a 94 kDa polypeptide. Gelatinolytic and type IV collagenolytic activities of the purified protein were measured and compared. Immunoglobulins purified from antisera raised against gelatinase inhibited both the gelatinase and type IV collagenase activities. The...

journal_title：Biochemical and biophysical research communications

authors： Morel F,Berthier S,Guillot M,Zaoui P,Massoubre C,Didier F,Vignais PV

更新日期：1993-02-26 00:00:00

abstract：:A murine IgG mAb, WR321, selected for the ability to bind to phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate, but an inability to bind to any of 17 other lipids, including phosphatidylinositol, was examined as a probe for studying interactions of HIV-1 with primary human peripheral blood mon...

journal_title：Biochemical and biophysical research communications

authors： Matyas GR,Wieczorek L,Bansal D,Chenine AL,Sanders-Buell E,Tovanabutra S,Kim JH,Polonis V,Alving CR

更新日期：2010-11-26 00:00:00

abstract：:Polarization of epithelial cells requires vectorial sorting and transport of polarity proteins to apical or basolateral domains. Kif5b is the mouse homologue of the human ubiquitous Kinesin Heavy Chain (uKHC). To investigate the function of Kif5b in epithelial cells, we examined the phenotypes of Kif5b-deficient MDCK ...

journal_title：Biochemical and biophysical research communications

authors： Cui J,Jin G,Yu B,Wang Z,Lin R,Huang JD

更新日期：2015-07-17 00:00:00

abstract：:Genes for the human vacuolar type H(+)-ATPase proteolipid (16-kDa) subunit were cloned and their nucleotide sequences were determined. Comparison of the deduced sequences indicated that at least four genes including pseudogenes are present in the human genome. One of them corresponded to that for the 16-kDa subunit ex...

journal_title：Biochemical and biophysical research communications

authors： Hasebe M,Hanada H,Moriyama Y,Maeda M,Futai M

更新日期：1992-03-16 00:00:00

abstract：:Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive. Here, we analyzed the differential expression of TFs and identified ZNF436 is upregulated in glioblastoma and Lower Grade Glioma patients. High expression of ZN...

journal_title：Biochemical and biophysical research communications

authors： Shang Y,Li Y,Zhang Y,Wang J

更新日期：2019-08-06 00:00:00

abstract：:Pyruvate carboxylase (PC) catalyzes the first committed step in gluconeogenesis. Here we investigated the effect of various hormones including cAMP, dexamethasone and insulin on the abundance of PC mRNA in the human hepatocyte cell line, HepG2. Treatment of HepG2 cells with 1 microM of glucagon increased the expressio...

journal_title：Biochemical and biophysical research communications

authors： Thonpho A,Sereeruk C,Rojvirat P,Jitrapakdee S

更新日期：2010-03-19 00:00:00

abstract：:Firefly luciferase is inactivated by singlet oxygen at near diffusion controlled rates, 1.9 X 10(9) M-1 s-1, based on direct comparison with the oxidation of L-histidine. The inactivation kinetics are multiphasic. Inactivation is inhibitable by NaN3. Surface-separated-sensitizer (SSS) system in which singlet oxygen is...

journal_title：Biochemical and biophysical research communications

authors： Thompson A,Nigro J,Seliger HH

更新日期：1986-11-14 00:00:00

abstract：:A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasit...

journal_title：Biochemical and biophysical research communications

authors： Cifuentes G,Vanegas M,Martinez NL,Pirajan C,Patarroyo ME

更新日期：2009-07-10 00:00:00

abstract：:Long-term glyburide therapy has been reported to improve glucose-induced insulin secretion in patients with NIDDM. We examined the effects of glyburide on the synthesis and release of insulin and insulin gene expression in isolated islets in vitro. Incubation with glyburide (500 ng/ml) significantly increased insulin ...

journal_title：Biochemical and biophysical research communications

authors： Yamato E,Ikegami H,Tahara Y,Fukuda M,Cha T,Kawaguchi Y,Fujioka Y,Noma Y,Shima K,Ogihara T

更新日期：1994-02-28 00:00:00

abstract：:Apoptosis is a well defined physiological process characterised by many specific features including DNA fragmentation and protease activation. Cell membrane-associated changes such as the altered exposure of phosphatidylserine and glycosylation patterns have also been described. We investigate here the change in expos...

journal_title：Biochemical and biophysical research communications

authors： Russell L,Waring P,Beaver JP

更新日期：1998-09-18 00:00:00