Abstract:
:We have analyzed heteroplasmy of mitochondrial DNA in clonal cultures from two patients with Kearns-Sayre syndrome, and have found that individual muscle or fibroblast clones contained either a mixed (i.e. heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e. homoplasmic at a level of detection of less than 1% deleted genomes). The heteroplasmic clones grew significantly more slowly than did "homoplasmic" clones, probably due to defects of respiratory chain enzymes containing mtDNA-encoded polypeptides.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Moraes CT,Schon EA,DiMauro S,Miranda AFdoi
10.1016/0006-291x(89)92499-6subject
Has Abstractpub_date
1989-04-28 00:00:00pages
765-71issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(89)92499-6journal_volume
160pub_type
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