The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.

abstract：:We report here the interaction of melittin with ganglioside GM1 by steady-state fluorescence, one-dimensional (1)H NMR spectroscopy and molecular modeling. In the presence of GM1 the emission maximum of melittin is blue shifted and fluorescence quenching efficiencies of iodide and acrylamide are substantially reduced,...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee C,Mukhopadhyay C

更新日期：2002-03-29 00:00:00

abstract：:COOH-terminal cytoplasmic domains of G protein-coupled receptors (GPCRs) have been shown to carry determinants that control their cell surface localization, internalization, and recycling. In attempts to seek cellular proteins that mediate these processes of PTH/PTH-related protein receptor (PTHR), one of the class B ...

journal_title：Biochemical and biophysical research communications

authors： Sugai M,Saito M,Sukegawa I,Katsushima Y,Kinouchi Y,Nakahata N,Shimosegawa T,Yanagisawa T,Sukegawa J

更新日期：2003-11-07 00:00:00

abstract：:CPI-17 is a protein phosphatase 1 (PP1) inhibitor that has been shown to act on the myosin light chain phosphatase. CPI-17 is phosphorylated on Thr-38 in vivo, thus enhancing its ability to inhibit PP1. Thr-38 has been shown to be the target of several protein kinases in vitro. Originally, the expression of CPI-17 was...

journal_title：Biochemical and biophysical research communications

authors： Dubois T,Howell S,Zemlickova E,Learmonth M,Cronshaw A,Aitken A

更新日期：2003-03-07 00:00:00

abstract：:We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cel...

journal_title：Biochemical and biophysical research communications

authors： Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

更新日期：2003-05-23 00:00:00

abstract：:Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are limi...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2013-11-01 00:00:00

abstract：:A cDNA encoding the entire tau subunit of rabbit skeletal muscle phosphorylase kinase was reconstructed and inserted into a plasmid containing the Escherichia coli ptac promoter and a constructed plasmid containing the ptac promoter and bacterial chloramphenicol acetyl transferase (CAT) gene, respectively. A significa...

journal_title：Biochemical and biophysical research communications

authors： Chen LR,Yuan CJ,Somasekhar G,Wejksnora P,Peterson JE,Myers AM,Graves L,Cohen PT,da Cruz e Silva EF,Graves DJ

更新日期：1989-06-15 00:00:00

abstract：:A heparan sulfate glycosaminoglycan chain, biotinylated at its reducing-end, was bound to a streptavidin-coated biochip. Surface plasmon resonance spectroscopy showed a low affinity interaction with antithrombin III (ATIII) when it was flowed over a surface containing heparan sulfate. ATIII bound tightly with high aff...

journal_title：Biochemical and biophysical research communications

authors： Hernaiz M,Liu J,Rosenberg RD,Linhardt RJ

更新日期：2000-09-16 00:00:00

abstract：:5-Bromodeoxyuridine (BrdU) modulates expression of particular genes associated with cellular differentiation and senescence. Our previous studies have suggested an involvement of chromatin structure in this phenomenon. Here, we examined the effect of 5-bromouracil on nucleosome positioning in vivo using TALS plasmid i...

journal_title：Biochemical and biophysical research communications

authors： Miki K,Shimizu M,Fujii M,Hossain MN,Ayusawa D

更新日期：2008-04-11 00:00:00

abstract：:Gene expression is the typical biological end point of interest following transfection. However, transcription may not accurately assess DNA uptake, or the ability of transfected DNA to be acted on by other enzymatic pathways. We have compared DNA uptake to gene expression and the unrelated enzymatic process of DNA do...

journal_title：Biochemical and biophysical research communications

authors： Pastwa E,Lubner EM,Mezhevaya K,Neumann RD,Winters TA

更新日期：2003-06-27 00:00:00

abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

journal_title：Biochemical and biophysical research communications

authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

更新日期：2021-02-05 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI 3-kinase) was partially purified from rat liver cytosol and used to synthesize phosphatidylinositol 3,4,5-trisphosphate (PIP3), using phosphatidylinositol 4,5-bisphosphate (PIP2) as a substrate. Purified PIP3 (free of chromatographic oxalate) activated protein kinase C (PKC) in the pr...

journal_title：Biochemical and biophysical research communications

authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

更新日期：1993-08-31 00:00:00

abstract：:The mouse disabled 2 interacting protein 2 (mDaIP2) had been obtained through yeast two hybrid system. It consists of 506 amino acids and its calculated molecular weight is 57.7 kDa. The protein contains N-terminal FCH domain and C-terminal SH3 domain. The SH3 domain interacts with the proline rich domain of mDab2 whi...

journal_title：Biochemical and biophysical research communications

authors： Choi YJ,Cho SY,Kim HW,Kim JA,Bae SH,Park SS

更新日期：2005-01-21 00:00:00

abstract：:A polymerase chain reaction-generated mouse ACTH-R probe was used to screen a mouse genomic library, and a clone of 13kb containing the entire coding sequence was isolated. The coding sequence shows 84% homology with the human gene at the DNA level and encodes a peptide with 89% homology to the human ACTH-R. This gene...

journal_title：Biochemical and biophysical research communications

authors： Cammas FM,Kapas S,Barker S,Clark AJ

更新日期：1995-07-26 00:00:00

abstract：:We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activatio...

journal_title：Biochemical and biophysical research communications

authors： Morishige KI,Inanobe A,Takahashi N,Yoshimoto Y,Kurachi H,Miyake A,Tokunaga Y,Maeda T,Kurachi Y

更新日期：1996-03-18 00:00:00

abstract：:The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts...

journal_title：Biochemical and biophysical research communications

authors： Zolk O,Solbach TF,Eschenhagen T,Weidemann A,Fromm MF

更新日期：2008-11-14 00:00:00

abstract：:Free fatty acid (FFA)-bound albumin, which is filtrated through the glomeruli and reabsorbed into proximal tubular cells, is one of the crucial mediators of tubular damage in proteinuric kidney disease. In this study, we examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its m...

journal_title：Biochemical and biophysical research communications

authors： Soumura M,Kume S,Isshiki K,Takeda N,Araki S,Tanaka Y,Sugimoto T,Chin-Kanasaki M,Nishio Y,Haneda M,Koya D,Kashiwagi A,Maegawa H,Uzu T

更新日期：2010-11-12 00:00:00

abstract：:Surfactant convertase is required for conversion of heavy density (H) natural surfactant to light density (L) subtype during cycling in vitro, a technique that reproduces surfactant metabolism. To study mechanisms of H to L conversion, we prepared liposomes of dipalmitoylphosphatidylcholine (DPPC) and phosphatidylglyc...

journal_title：Biochemical and biophysical research communications

authors： Dhand R,Sharma VK,Teng AL,Krishnasamy S,Gross NJ

更新日期：1998-03-27 00:00:00

abstract：:The effects of trace acetylation on the contact sites in peptide-antibody binding have been investigated by using a label selection method. A 13-residue synthetic peptide having three lysines (LKLVEQQNPKVKL) corresponding to sequence position 155-168 of beta 1,4-galactosyltransferase was used in this study. The four a...

journal_title：Biochemical and biophysical research communications

authors： Yadav SP,Rawitch AB

更新日期：1994-12-30 00:00:00

abstract：:CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1. In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown. Transient expression assays with plasmi...

journal_title：Biochemical and biophysical research communications

authors： Lapointe R,Lemieux R,Darveau A

更新日期：1996-12-24 00:00:00

abstract：:It has been well documented that tumor suppressor p53 is mutated in about 50% of all human tumors. p53 status might be one of the critical determinants for the chemo-sensitivity of human tumors. In the present study, we have found that p53 family member p73 as well as 14-3-3sigma is down-regulated in response to adria...

journal_title：Biochemical and biophysical research communications

authors： Sang M,Li Y,Ozaki T,Ono S,Ando K,Yamamoto H,Koda T,Geng C,Nakagawara A

更新日期：2006-08-18 00:00:00

abstract：:We have examined the restriction digest patterns of CCGG sequences in Kiras, Ha-ras, and c-myc oncogenes in rat tracheal epithelial cells transformed in vitro by 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene/12-O-tetradecanoylphorbol-13-acetate (TPA), or TPA alone. Oncogenes c-myc and Ha-ras in transformed cell lines...

journal_title：Biochemical and biophysical research communications

authors： Mass MJ,Schorschinsky NS,Lasley JA,Beeman DK,Austin SJ

更新日期：1989-10-31 00:00:00

abstract：:Dinoflagellates are protists with permanently condensed chromosomes that lack histones and whose nuclear membrane remains intact during mitosis. These unusual nuclear characters have suggested that the typical cell cycle regulators might be slightly different than those in more typical eukaryotes. To test this, a cycl...

journal_title：Biochemical and biophysical research communications

authors： Bertomeu T,Morse D

更新日期：2004-10-29 00:00:00

abstract：:The murine C-5 cytosine DNA methyltransferase (MTase, E.C.2.1.1.37) containing a hexahistidine affinity leader peptide has been expressed at levels which are at least 50-fold higher than previously reported. The recombinant enzyme has activity levels similar to the wild-type enzyme. The recombinant polypeptide binds t...

journal_title：Biochemical and biophysical research communications

authors： Glickman JF,Reich NO

更新日期：1994-11-15 00:00:00

abstract：:KRAS is the key mutated gene in pancreatic ductal adenocarcinoma (PDAC). Emerging evidence indicates that KRas modulates endocytic uptake. The present study aimed to explore the fate of early endosomal trafficking under the control of KRas expression in PDAC. Surprisingly, PANC-1 cells lacking KRas exhibited significa...

journal_title：Biochemical and biophysical research communications

authors： Teske C,Schweitzer C,Palamidessi A,Aust DE,Scita G,Weitz J,Welsch T

更新日期：2017-11-04 00:00:00

abstract：:The proteasome is a recently identified intracellular protease whose catalytic active site is a threonine residue and has been shown to play key roles in a variety of important intracellular events, including cell cycle progression, the antigen-presenting pathway, and apoptosis. However, its biological significance in...

journal_title：Biochemical and biophysical research communications

authors： Oikawa T,Sasaki T,Nakamura M,Shimamura M,Tanahashi N,Omura S,Tanaka K

更新日期：1998-05-08 00:00:00

abstract：:Iron administration to HeLa cells stimulates the accumulation of H-subunit and L-subunit rich isoferritins at similar extent. The increase in both types of isoferritins is accompanied by an increase in the amount of messenger RNAs specific for H and L subunits. The increase in the amount of these messenger RNAs, which...

journal_title：Biochemical and biophysical research communications

authors： Cairo G,Bardella L,Schiaffonati L,Arosio P,Levi S,Bernelli-Zazzera A

更新日期：1985-11-27 00:00:00

abstract：:The cooperative nature of interaction of cationic surfactants with short oligonucleotides leading to eventual stabilization of DNA duplexes is demonstrated. At submicellar concentrations and DNA:surfactant charge ratios of 0.2 to 0.8, the association of single chain (CTAB) and double chain (DOTAP) surfactants to oligo...

journal_title：Biochemical and biophysical research communications

authors： Pattarkine MV,Ganesh KN

更新日期：1999-09-16 00:00:00

abstract：:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosp...

journal_title：Biochemical and biophysical research communications

authors： Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

更新日期：2007-10-05 00:00:00

abstract：:Membrane rafts are small and dynamic regions enriched in sphingolipids, cholesterol, ganglioside GM1 and protein markers like flotillins, forming the flatter domains or caveolins, which are characterized as stable flask-shape invaginations. We explored whether membrane rafts participate in the entry of Trypanosoma cru...

journal_title：Biochemical and biophysical research communications

authors： Barrias ES,Dutra JM,De Souza W,Carvalho TM

更新日期：2007-11-23 00:00:00

abstract：:It is considered that the essence of acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which mainly is attributed to the release of inflammatory mediators. Recent studies demonstrated that irisin, which is a metabolism associated factor after physical exercise could suppression...

journal_title：Biochemical and biophysical research communications

authors： Shao L,Meng D,Yang F,Song H,Tang D

更新日期：2017-05-27 00:00:00