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Identification of binding domains for basic fibroblast growth factor in proteoglycan macrophage colony-stimulating factor.

Abstract：

:We recently demonstrated that proteoglycan macrophage colony-stimulating factor (PG-M-CSF) binds basic fibroblast growth factor (bFGF) and neutralizes the biological activity of bFGF. In this study, we identified the binding sites of PG-M-CSF for bFGF. We examined the binding of bFGF to overlapping 12-mer peptides with the sequence of the putative binding region. High affinity binding was detected at two peaks; one consisted of the three adjacent peptides, 212-223, 213-224 and 214-225 and the other, of the three adjacent peptides, 246-257, 247-258 and 248-259. The synthetic peptide (212VDPGSAKQRPPRST225) did not inhibit bFGF binding to another peptide (246PQPRPSVGAFNPGM259), and vice versa. However, both peptides inhibited the bFGF-induced but not platelet-derived growth factor-induced stimulation of DNA synthesis in murine Balb/c 3T3 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzu S,Kimura F,Matsumoto H,Yamada M,Hashimoto K,Shimamura S,Motoyoshi K

doi

10.1006/bbrc.1996.5968

subject

Has Abstract

pub_date

1997-01-13 00:00:00

pages

392-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)95968-9

journal_volume

230

pub_type

杂志文章

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