Comparison of two independent cDNA clones reported to encode beta 1,4 galactosyltransferase.

abstract：:Glial cells have been shown to induce enzyme activities, which are characteristically high in brain capillaries, in cerebral and non cerebral endothelial cells in culture. We evaluated the activity of gamma-glutamyl transpeptidase (gamma GT) in freshly isolated (ex vivo) bovine blood (BEC) and lymphatic (LEC) endothel...

journal_title：Biochemical and biophysical research communications

authors： Weber E,Lorenzoni P,Raffaelli N,Cavina N,Sacchi G

更新日期：1996-08-23 00:00:00

abstract：:Transforming growth factor beta 1 (TGF beta 1) has been reported to be secreted and to act within the somatic cells of the testis. We examined whether the TGF beta 1 expression is present at mRNA and protein levels in purified rat Sertoli cells (SC), purified pachytene spermatocytes (SPC), and early spermatids (SPT) c...

journal_title：Biochemical and biophysical research communications

authors： Avallet O,Gomez E,Vigier M,Jégou B,Saez JM

更新日期：1997-09-29 00:00:00

abstract：:Neddylation is an ubiquitin-like modification of proteins that affects the activity, stability and protein-protein interaction of its substrates. Apart from its role as a promoter for Cullin ring E3 ligase to positively regulate the ubiquitylation process, other functional studies about neddylation are still lacking. ...

journal_title：Biochemical and biophysical research communications

authors： Li S,Fang W,Cui Y,Shi H,Chen J,Li L,Zhang L,Zhang X

更新日期：2020-09-03 00:00:00

abstract：:We previously showed that the epidermal growth factor (EGF) receptor in human A431 epidermoid carcinoma cells undergoes a slow post-translational modification whereby it acquires (t1/2 = 30-40 min) EGF binding capacity (Slieker, L.J., et. al. (1986) J. Biol. Chem., 261, 15233-15241). This activation occurs in the endo...

journal_title：Biochemical and biophysical research communications

authors： Slieker LJ,Martensen TM,Lane MD

更新日期：1988-05-31 00:00:00

abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

journal_title：Biochemical and biophysical research communications

authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

更新日期：2019-07-12 00:00:00

abstract：:Opioid agonists either potentiate or suppress basal cAMP production in SK-N-SH cells. The inhibitory effect is mediated by PTX-sensitive GTP-binding proteins, while the stimulatory effect involves Ca++ entry and calmodulin activation. Both pathways can be activated simultaneously by opioid agonists. Low (nM) concentra...

journal_title：Biochemical and biophysical research communications

authors： Sarne Y,Rubovitch V,Fields A,Gafni M

更新日期：1998-05-08 00:00:00

abstract：:p120-Catenin is known to play important roles in cell-cell adhesion stability by binding to cadherin and morphological changes of cells by regulating small RhoGTPase activities. Although the expression and binding states of p120-catenin are thought to dynamically change due to morphological adaptation of endothelial c...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto N,Segawa K,Kanzaki M,Ohashi T,Sato M

更新日期：2010-07-30 00:00:00

abstract：:The posttranscriptional RNA editing by the type 1 adenosine deaminase acting on RNAs (ADAR1), expressed as p110 and p150 isoforms, is important for both physiological and pathological processes. Their expression and significance in leukemias remain unknown. Here, we investigated the expression of ADAR1 in Chinese pedi...

journal_title：Biochemical and biophysical research communications

authors： Ma CH,Chong JH,Guo Y,Zeng HM,Liu SY,Xu LL,Wei J,Lin YM,Zhu XF,Zheng GG

更新日期：2011-03-11 00:00:00

abstract：:Purified Human Immunodeficiency Virus (HIV) was solubilized in octylglucopyranoside. After centrifugation, the supernatant was added to lipid-detergent mixed micelles. Formation of virosomes occurred during overnight dialysis. Centrifugation on a continuous glycerol gradient showed that envelope glycoproteins (gp120 a...

journal_title：Biochemical and biophysical research communications

authors： Cornet B,Vandenbranden M,Cogniaux J,Giurgea L,Dekegel D,Ruysschaert JM

更新日期：1990-02-28 00:00:00

abstract：:The activation of vitamin D requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. However, it remains unclear which enzyme is relevant to vitamin D 25-hydroxylation. Recently, human CYP2R1 has been reported to be a potential candidate for a hepatic vitamin D 25-hydroxylase. Thus, vitamin D met...

journal_title：Biochemical and biophysical research communications

authors： Shinkyo R,Sakaki T,Kamakura M,Ohta M,Inouye K

更新日期：2004-11-05 00:00:00

abstract：:Dysregulation and aggregation of the peptide hormone IAPP (islet amyloid polypeptide, a.k.a. amylin) into soluble oligomers that appear to be cell-toxic is a known aspect of diabetes mellitus (DM) Type 2 pathology. IAPP aggregation is influenced by several factors including interactions with metal ions such as Cu(II)....

journal_title：Biochemical and biophysical research communications

authors： Dong X,Svantesson T,Sholts SB,Wallin C,Jarvet J,Gräslund A,Wärmländer SKTS

更新日期：2019-03-19 00:00:00

abstract：:Stretch activation of cation-permeable channels may be an important proximal sensory mechanism in mechanotransduction. As actin filaments may mediate cellular responses to changes of the mechanical properties of the substrate and regulate stretch-induced calcium transients, we examined the role of actin filaments and ...

journal_title：Biochemical and biophysical research communications

authors： Wu Z,Wong K,Glogauer M,Ellen RP,McCulloch CA

更新日期：1999-08-02 00:00:00

abstract：:Acute stress has been shown to enhance learning and memory ability, predominantly through the action of corticosteroid stress hormones. However, the valuable targets for promoting learning and memory induced by acute stress and the underlying molecular mechanisms remain unclear. Acid-sensing ion channels (ASICs) play ...

journal_title：Biochemical and biophysical research communications

authors： Ye S,Yang R,Xiong Q,Yang Y,Zhou L,Gong Y,Li C,Ding Z,Ye G,Xiong Z

更新日期：2018-04-15 00:00:00

abstract：:We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal macrophages. Indomethacin a potent inhibitor of prostaglandin synthesis caused a dose-dependent augmentation of lipopolysaccharide induced interleukin production (up to 7-fold at 5 microM). ...

journal_title：Biochemical and biophysical research communications

authors： Kunkel SL,Chensue SW

更新日期：1985-04-30 00:00:00

abstract：:A 67 kDa cytosolic FERM domain containing protein having significant protein tyrosine phosphatases activity (PTPL) has been purified to homogeneity from Setaria cervi, a bovine filarial parasite. The MALDI-MS/MS analysis of the purified protein revealed 16 peptide peaks showing nearest match to Brugia malayi Moesin/ez...

journal_title：Biochemical and biophysical research communications

authors： Singh N,Heneberg P,Singh N,Singh SK,Rathaur S

更新日期：2015-02-27 00:00:00

abstract：:The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

journal_title：Biochemical and biophysical research communications

authors： Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

更新日期：2011-08-12 00:00:00

abstract：:Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic reticulum (ER) via the inositol 1, 4, 5-trisphosphate receptor (IP3R)...

journal_title：Biochemical and biophysical research communications

authors： Sakuragi S,Niwa F,Oda Y,Mikoshiba K,Bannai H

更新日期：2017-05-13 00:00:00

abstract：:Three small serum proteins (SSP-1, -2, and -3), with molecular masses of 6.5-10kDa, were isolated from Habu (Trimeresurus flavoviridis) serum, and the amino acid sequences were determined by protein and cDNA analysis. Despite only limited sequence identity to any mammalian prostatic secretory protein of 94 amino acids...

journal_title：Biochemical and biophysical research communications

authors： Aoki N,Sakiyama A,Deshimaru M,Terada S

更新日期：2007-07-27 00:00:00

abstract：:Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its systemic effects, cellular functions of membranous DPP-4 are less clear. Here we studied the role of DPP-4 in hepatic energy metabolism. In order to distinguish sys...

journal_title：Biochemical and biophysical research communications

authors： Rufinatscha K,Radlinger B,Dobner J,Folie S,Bon C,Profanter E,Ress C,Salzmann K,Staudacher G,Tilg H,Kaser S

更新日期：2017-04-01 00:00:00

abstract：:Sinusoidal endothelial cells proliferate following hepatocyte regeneration in the liver after partial resection. The expressions of vascular endothelial growth factor (VEGF) and its receptors, flt-1 and KDR/flk-1, were studied by Northern blotting in isolated rat liver cells and 70% resected rat liver. VEGF was expres...

journal_title：Biochemical and biophysical research communications

authors： Mochida S,Ishikawa K,Inao M,Shibuya M,Fujiwara K

更新日期：1996-09-04 00:00:00

abstract：:When porcine adrenocortical microsomes were treated with Fe2+, enhanced production of malondialdehyde was observed as a result of membrane lipid peroxidation. By treatment of the microsomes with Fe2+, the activity of delta 5-3 beta-hydroxysteroid dehydrogenase coupled with delta 5-delta 4 isomerase, concentration of c...

journal_title：Biochemical and biophysical research communications

authors： Imataka H,Suzuki K,Tamaoki B

更新日期：1985-04-30 00:00:00

abstract：:The highly reactive electrophile, methylglyoxal (MG), a break down product of carbohydrates, is a major environmental mutagen having potential genotoxic effects. Previous studies have suggested the reaction of MG with free amino groups of proteins forming advanced glycation end products (AGEs). This results in the gen...

journal_title：Biochemical and biophysical research communications

authors： Ahmad S,Moinuddin,Dixit K,Shahab U,Alam K,Ali A

更新日期：2011-04-15 00:00:00

abstract：:We prepared a cleavage site-directed antiserum against Caspase-3 (anti-p20/17), which reacts with the p20/17 fragment (p20/17) activated by cleavage but not proCaspase-3 (p32), and examined the relationship between the activation of Caspase-3 and apoptosis. We identified p20/17-positive cells where cell death occurs n...

journal_title：Biochemical and biophysical research communications

authors： Kouroku Y,Urase K,Fujita E,Isahara K,Ohsawa Y,Uchiyama Y,Momoi MY,Momoi T

更新日期：1998-06-29 00:00:00

abstract：:Previously by selection and inbreeding of Wistar rats susceptible or resistant to the cataractogenic effect of galactose the S and R rat strains were developed as a model of oxidative stress. It was earlier found S rats have elevated level of OH-radical generation and enhanced lipid peroxidation compared with that for...

journal_title：Biochemical and biophysical research communications

authors： Yelinova V,Glazachev Y,Khramtsov V,Kudryashova L,Rykova V,Salganik R

更新日期：1996-04-16 00:00:00

abstract：:The effect of secretory phospholipase A2 (sPLA2) on intracellular Ca2+ signaling in human astrocytoma cells was studied. sPLA2 increased cytosolic [Ca2+] ([Ca2+]c) in both Ca2+-containing and Ca2+-free medium, thus suggesting Ca2+ release from intracellular stores. The activation by sPLA2 of arachidonate release via c...

journal_title：Biochemical and biophysical research communications

authors： Hernández M,Barrero MJ,Alvarez J,Montero M,Sánchez Crespo M,Nieto ML

更新日期：1999-06-24 00:00:00

abstract：:The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. This mode of inhibition is conserved between mammalian and Dictyostelium...

journal_title：Biochemical and biophysical research communications

authors： Ryves WJ,Harwood AJ

更新日期：2001-01-26 00:00:00

abstract：:Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostagland...

journal_title：Biochemical and biophysical research communications

authors： Marquis NR,Vigdahl RL,Tavormina PA

更新日期：1969-09-10 00:00:00

abstract：:cDNAs were molecularly cloned for proteins specifically expressed in embryo as well as in a chemically induced rat pancreatic B cell tumor in which virally related oncogenes such as v-myc, v-src, v-yes, v-mos and v-kis were previously demonstrated not to be expressed. A plasmid cDNA library consisting of 48,000 indepe...

journal_title：Biochemical and biophysical research communications

authors： Soma G,Kitahara N,Andoh T

更新日期：1984-10-15 00:00:00

abstract：:Combined-modality treatment has improved the outcome in cases of various solid tumors, and radiosensitizers are used to enhance the radiotherapeutic efficiency. Rosiglitazone, a synthetic ligand of peroxisome proliferator-activated receptors gamma used in the treatment of type-2 diabetes, has been shown to reduce tumo...

journal_title：Biochemical and biophysical research communications

authors： Chiu SJ,Hsaio CH,Tseng HH,Su YH,Shih WL,Lee JW,Chuah JQ

更新日期：2010-04-09 00:00:00

abstract：:We previously identified the novel gene, periodontal ligament-associated protein-1 (PLAP-1)/asporin and reported that PLAP-1/asporin inhibited bone morphogenetic protein-2 (BMP-2)-induced cytodifferentiation of periodontal ligament (PDL) cells probably by direct interaction with BMP-2. Here, we elucidated the detailed...

journal_title：Biochemical and biophysical research communications

authors： Tomoeda M,Yamada S,Shirai H,Ozawa Y,Yanagita M,Murakami S

更新日期：2008-06-27 00:00:00