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Short-term stimulation of lipogenesis by triiodothyronine in maintenance cultures of rat hepatocytes.

Abstract：

:Within 4 h following the addition of 3,3',5 triiodo-L-thyronine to monolayer cultures of hepatocytes isolated from hypothyroid rats, a very distinct stimulation of fatty acid and cholesterol synthesis, measured as incorporation of either [1-14C]acetate or [3H]H2O into these lipid fractions, is observed. A smaller but significant increase in the rate of lipogenesis occurs in hepatocytes derived from euthyroid animals. These stimulatory effects of triiodothyronine are also observed in the presence of cycloheximide, indicating that the described early and direct stimulation of lipogenesis by the thyroid hormone is, at least in part, independent of protein synthesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gnoni GV,Geelen MJ,Bijleveld C,Quagliariello E,van den Bergh SG

doi

10.1016/0006-291x(85)90078-6

subject

Has Abstract

pub_date

1985-04-30 00:00:00

pages

525-30

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90078-6

journal_volume

128

pub_type

杂志文章

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