Inhibitory effect of arachidonic acid on GTPase activating protein is antagonized by 1-stearoyl, 2-arachidonoyl glycerol.

abstract：:Autophagy is the bulk degradation of cytosolic materials in lysosomes/vacuoles of eukaryotic cells. In the yeast Saccharomyces cerevisiae, 17 Atg proteins are known to be involved in autophagosome formation. Genome wide analyses have shown that Atg17 interacts with numerous proteins. Further studies on these interacti...

journal_title：Biochemical and biophysical research communications

authors： Kabeya Y,Kawamata T,Suzuki K,Ohsumi Y

更新日期：2007-05-04 00:00:00

abstract：:Neonatal hypoxia can induce the persisting brain dysfunctions and subsequently result in the behavioral abnormalities in adulthood. Improving mitochondrial functions were suggested as the effective strategy for brain functional recovery. In this study, we tested the effects of physical exercise, a well-established way...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Ye R,Liang R,Xing F

更新日期：2020-03-05 00:00:00

abstract：:This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...

journal_title：Biochemical and biophysical research communications

authors： Cui R,He J,Mei R,de Fromentel CC,Martel-Planche G,Taniere P,Hainaut P

更新日期：2005-08-22 00:00:00

abstract：:Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signa...

journal_title：Biochemical and biophysical research communications

authors： Eto K,Eda K,Kanemoto S,Abe S

更新日期：2006-11-17 00:00:00

abstract：:How rod-shaped bacteria form and maintain their shape is an important question in bacterial cell biology. Results from fluorescent light microscopy have led many to believe that the actin homolog MreB and a number of other proteins form long helical filaments along the inner membrane of the cell. Here we show using el...

journal_title：Biochemical and biophysical research communications

authors： Swulius MT,Chen S,Jane Ding H,Li Z,Briegel A,Pilhofer M,Tocheva EI,Lybarger SR,Johnson TL,Sandkvist M,Jensen GJ

更新日期：2011-04-22 00:00:00

abstract：:In this study, the effects of acetylsalicylic acid (aspirin) on the expression of uPAR and the mechanism by which it regulates expression of uPAR was examined in two different colon cancer cell lines HCT116 and GEO, respectively. The study shows that under physiological concentration, aspirin upregulates steady-state ...

journal_title：Biochemical and biophysical research communications

authors： Jamaluddin MS

更新日期：2006-09-22 00:00:00

abstract：:We have previously shown that sphingosine 1-phosphate (S1P) stimulates motility of human umbilical vein endothelial cells (HUVECs) (O.-H. Lee et al., Biochem. Biophys. Res. Commun. 264, 743-750, 1999). To investigate the molecular mechanisms by which S1P stimulates HUVEC motility, we examined tyrosine phosphorylation ...

journal_title：Biochemical and biophysical research communications

authors： Lee OH,Lee DJ,Kim YM,Kim YS,Kwon HJ,Kim KW,Kwon YG

更新日期：2000-02-05 00:00:00

abstract：:The three mammalian Raf proteins (A-Raf, B-Raf, and C-Raf) are key components of the MAPK pathway. Although diverse functions have been proposed for Raf kinases, it is still not clear how interacting proteins contribute to differences in the signaling functions of the three Raf kinases. Here, we report the comparative...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Guo H,Huang Y,Hao PQ,Yang Y,Liu Y,Guo XX,Hao Q,An S,Xu TR

更新日期：2019-07-05 00:00:00

abstract：:We prepared a cleavage site-directed antiserum against Caspase-3 (anti-p20/17), which reacts with the p20/17 fragment (p20/17) activated by cleavage but not proCaspase-3 (p32), and examined the relationship between the activation of Caspase-3 and apoptosis. We identified p20/17-positive cells where cell death occurs n...

journal_title：Biochemical and biophysical research communications

authors： Kouroku Y,Urase K,Fujita E,Isahara K,Ohsawa Y,Uchiyama Y,Momoi MY,Momoi T

更新日期：1998-06-29 00:00:00

abstract：:Nanosecond and steady fluorescence techniques have been employed to study the interaction of retinol with protein disulfide isomerase (PDI). Retinol binds tightly to PDI; and the rotational correlation time (θ = 36 ns) corresponds to a monomeric subunit of 55 kDa. The enzyme does not undergo aggregation in the p...

journal_title：Biochemical and biophysical research communications

authors： Churchich JE

更新日期：1999-07-22 00:00:00

abstract：:Horny Goat Weed is a commonly used in Chinese herbal medicine. And it is used in multiple kinds of diseases including cardiovascular diseases. Icariin is the major component isolated from Horny Goat Weed. It is reported to have lipid-lowering effect. In atherosclerosis, icariin attenuate the enhanced prothrombotic sta...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Wang YS,Song SL,Liang H,Ji AG

更新日期：2016-02-19 00:00:00

abstract：:The process in which nucleotide is buried into the active site of heavy meromyosin was studied with stopped-flow apparatus by monitoring the time-course of the large fluorescence increase of 1,N6-ethenoadenosine triphosphate (epsilon-ATP) when it binds from acrylamide-containing solutions. We have recently reported th...

journal_title：Biochemical and biophysical research communications

authors： Ando T,Duke JA

更新日期：1983-08-30 00:00:00

abstract：:The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3 cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK channels has recently been described as being an ATP-sensitive K+ channel. This paper shows that Xenopus expression of this new channel that we c...

journal_title：Biochemical and biophysical research communications

authors： Duprat F,Lesage F,Guillemare E,Fink M,Hugnot JP,Bigay J,Lazdunski M,Romey G,Barhanin J

更新日期：1995-07-17 00:00:00

abstract：:Hypothermia followed by slow rewarming is neuroprotective for ischemic stroke. However, slow rewarming causes patients' longer stay in intensive care unit and increases the risk of hypothermic complications. Hypothermia followed by rapid rewarming (HTRR) is more convenient; but it exacerbates intracranial hypertension...

journal_title：Biochemical and biophysical research communications

authors： Zhu SZ,Gu Y,Wu Z,Hu YF,Pan SY

更新日期：2016-05-20 00:00:00

abstract：:Most of the ADP-glucose pyrophosphorylases from different sources are stable to a heat treatment. We found that in the potato (Solanum tuberosum L.) tuber enzyme, the intermolecular disulfide bridge located between Cys12 of the small subunits is responsible for the stability at 60 degrees C. When this unique disulfide...

journal_title：Biochemical and biophysical research communications

authors： Ballicora MA,Fu Y,Frueauf JB,Preiss J

更新日期：1999-04-21 00:00:00

abstract：:Perforin, a potent pore-forming protein, plays an important role in killer lymphocyte-mediated cytolysis. The studies on perforin, although already extensive, have been hampered by the limited amount of perforin naturally available from killer lymphocytes. In the present study, a full-length mouse perforin was express...

journal_title：Biochemical and biophysical research communications

authors： Liu CC,Persechini PM,Young JD

更新日期：1994-05-30 00:00:00

abstract：:Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing redox-active enzyme that is thought to be important during carcinogenesis. We have recently shown that treatment with statins, HMGCoA reductase inhibitors, reduces the levels of TrxR1 in liver of both rat and human. The reduced TrxR1 levels were correlated...

journal_title：Biochemical and biophysical research communications

authors： Ekström L,Johansson M,Monostory K,Rundlöf AK,Arnér ES,Björkhem-Bergman L

更新日期：2013-01-04 00:00:00

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:Tankyrases (TNKS and TNKS2) are members of poly(ADP-ribose) polymerase (PARP) family proteins. Tankyrase has multiple ankyrin repeat cluster (ARC) domains, which recognize the tankyrase-binding motifs in proteins including the telomeric protein, TRF1 and Wnt signal regulators, AXINs. However, the functional significan...

journal_title：Biochemical and biophysical research communications

authors： Mizutani A,Seimiya H

更新日期：2020-02-19 00:00:00

abstract：:A large proportion of the NSCLC patients were insensitive to radiotherapy, but the exact mechanism is still unclear. This study explored the role of miR-25 in regulating sensitivity of NSCLC cells to ionizing radiation (IR) and its downstream targets. Based on measurement in tumor samples from NSCLC patients, this stu...

journal_title：Biochemical and biophysical research communications

authors： He Z,Liu Y,Xiao B,Qian X

更新日期：2015-02-13 00:00:00

abstract：:With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time. The results show PO 200 μM + XSS 10 μM, PO 300 μM + XSS 15 μM, and PO 400 μM + XSS 20 μM can significantly increase the level of uric acid in the zebrafish...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Li Q,Wang F,Xing C

更新日期：2019-01-08 00:00:00

abstract：:Regarding the molecular mechanism of dynamin in receptor-mediated endocytosis, GTPase activity of dynamin has been thought to have a critical role in endocytic vesicle internalization. However, a recent report suggested that GTP-binding to dynamin itself activates the dynamin to recruit molecular machinery necessary f...

journal_title：Biochemical and biophysical research communications

authors： Jeong MJ,Yoo J,Lee SS,Lee KI,Cho A,Kwon BM,Moon MJ,Park YM,Han MY

更新日期：2001-04-27 00:00:00

abstract：:CRACR2A protein is described in T cells as an EF-hand-containing modulator of calcium-release-activated calcium (CRAC) channels. Here we sought relevance to calcium entry of endothelial cells. Unexpectedly, short interfering RNA designed to deplete CRACR2A had no effect on CRAC channels in endothelial cells but reduce...

journal_title：Biochemical and biophysical research communications

authors： Wilson LA,McKeown L,Tumova S,Li J,Beech DJ

更新日期：2015-01-02 00:00:00

abstract：:Fifteen luciferase plasmid constructs driven by various promoters including cytomegalovirus (CMV), Rous sarcoma virus (RSV), human serum albumin (SA), alpha-1 antitrypsin (AAT), cytochrome P450 CYP1A2, CYP2C9, CYP2C18, CYP2D6, CYP3A4, mouse CYP2b10, human amyloid precursor protein (APP), chicken beta actin (ACT), nucl...

journal_title：Biochemical and biophysical research communications

authors： Al-Dosari M,Zhang G,Knapp JE,Liu D

更新日期：2006-01-13 00:00:00

abstract：:Although TRPV1 and TRPM8 agonists (vanilloid capsaicin and menthol, respectively) at high concentrations inhibit action potential conduction, it remains to be unknown whether TRPA1 agonists have a similar action. The present study examined the actions of TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AI...

journal_title：Biochemical and biophysical research communications

authors： Matsushita A,Ohtsubo S,Fujita T,Kumamoto E

更新日期：2013-04-26 00:00:00

abstract：:Endothelialization has been considered a promising method to improve the biocompatibility of vascular implanted biomaterials. However, little is known about the anti-coagulation, anti-inflammatory, anti-atherosclerosis and anti-shedding property of the attached endothelial cells (ECs) and the relationship with their b...

journal_title：Biochemical and biophysical research communications

authors： Li J,Zhang K,Wu J,Liao Y,Yang P,Huang N

更新日期：2015-01-09 00:00:00

abstract：:In a previous report we described Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor (IR) tyrosine kinase (TK) in vitro. The question remained whether the observed phosphorylation was exclusive for the in vitro activated receptor or a more general, mechanism of the activated receptor in...

journal_title：Biochemical and biophysical research communications

authors： Tennagels N,Telting D,Parvaresch S,Maassen JA,Klein HW

更新日期：2001-03-30 00:00:00

abstract：:Insulin and glucagon secretion from the islets of Langerhans is highly regulated. Although an increased plasma glucose level is the major stimulus for insulin exocytosis, roles for glutamine and glutamate have been suggested. Interestingly, the islet cells display elements associated with synaptic transmission. In the...

journal_title：Biochemical and biophysical research communications

authors： Gammelsaeter R,Jenstad M,Bredahl MK,Gundersen V,Chaudhry FA

更新日期：2009-04-10 00:00:00

abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

journal_title：Biochemical and biophysical research communications

authors： Takino T,Guo L,Domoto T,Sato H

更新日期：2013-07-05 00:00:00

abstract：:Human PTK7 is a defective receptor protein tyrosine kinase and its expression is upregulated in various cancers including colorectal carcinomas. To determine whether PTK7 functions in angiogenesis, we have expressed and purified the extracellular domain of PTK7 (soluble PTK7; sPTK7) as a decoy receptor to counteract t...

journal_title：Biochemical and biophysical research communications

authors： Shin WS,Maeng YS,Jung JW,Min JK,Kwon YG,Lee ST

更新日期：2008-07-11 00:00:00