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The process in which nucleotide is buried into the active site of heavy meromyosin.

Abstract：

:The process in which nucleotide is buried into the active site of heavy meromyosin was studied with stopped-flow apparatus by monitoring the time-course of the large fluorescence increase of 1,N6-ethenoadenosine triphosphate (epsilon-ATP) when it binds from acrylamide-containing solutions. We have recently reported that free epsilon-ATP fluorescence is effectively quenched by acrylamide while bound epsilon-ATP is resistant to quenching by acrylamide. In the present study it was found that in the first step the phosphate moiety binds at a high rate, while the adenine moiety is still on the rim of the active site; the adenine moiety is then pulled into a crevice, and finally epsilon-ATP hydrolysis occurs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ando T,Duke JA

doi

10.1016/0006-291x(83)91005-7

subject

Has Abstract

pub_date

1983-08-30 00:00:00

pages

312-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91005-7

journal_volume

115

pub_type

杂志文章

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