Crystal structure of a substrate-binding protein from Rhodothermus marinus reveals a single α/β-domain.

abstract：:Chemotherapeutic efficacy is also regulated by the tumor microenvironment. IL-6 produced by TAMs and downstream IL-6/STAT3 signaling pathway is central regulator in chemotherapeutic response. The M2-like phenotype of TAMs is characterized by elevated iron uptake. Whether iron participates in chemo-resistance need to b...

journal_title：Biochemical and biophysical research communications

authors： Li J,He K,Liu P,Xu LX

更新日期：2016-06-24 00:00:00

abstract：:Actin-related proteins share significant homology with conventional actins and are classified into subfamilies based on the similarity of their sequences and functions. The Arp4 subfamily of Arps is localized in the nucleus, and a mammalian isoform, ArpNbeta (also known as BAF53), is a component of the chromatin remod...

journal_title：Biochemical and biophysical research communications

authors： Kuroda Y,Oma Y,Nishimori K,Ohta T,Harata M

更新日期：2002-11-29 00:00:00

abstract：:Two different types of fumarase were found in sonic extracts of Escherichia coli; one required Fe-S for the enzyme activity, and the other did not. When the cells were grown without aeration, the Fe-S-independent enzyme occupied over 80% of the overall fumarase activity. Highly purified Fe-S-independent enzyme was sug...

journal_title：Biochemical and biophysical research communications

authors： Yumoto N,Tokushige M

更新日期：1988-06-30 00:00:00

abstract：:Many infections are associated with diabetes, as the ability of the body to fight pathogens is impaired. Recently, low levels of defensins have been found in diabetic rodents. However, whether hyperglycemia and/or insulin deficiency/insensitivity is the reason for the reduced defensin levels is still unknown. To study...

journal_title：Biochemical and biophysical research communications

authors： Barnea M,Madar Z,Froy O

更新日期：2008-03-07 00:00:00

abstract：:Hepatitis B virus X protein (HBx protein), which seems to be involved in hepatocarcinogenesis, was studied for its effect on cell growth regulation. We examined the response to growth inhibition of transforming growth factor beta 1 (TGF-beta 1) in HBx gene-introduced cells. HBx gene in pRc/CMV was transfected to mink ...

journal_title：Biochemical and biophysical research communications

authors： Oshikawa O,Tamura S,Kawata S,Ito N,Tsushima H,Kiso S,Matsuda Y,Yamada A,Tamai S,Matsuzawa Y

更新日期：1996-05-24 00:00:00

abstract：:Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport and/or stabilization by acting as a molecular chaperone, leading to inhibition of apoptosis by both caspase dependent and/or independent pathways. HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell ...

journal_title：Biochemical and biophysical research communications

authors： Sarkar R,Mukherjee S,Biswas J,Roy M

更新日期：2012-10-12 00:00:00

abstract：:In the brains of Alzheimer's disease patients, the tau protein abnormally aggregates to form an insoluble paired helical filament (PHF). Since the third repeat structure (R3) of the tau microtubule-binding domain plays an essential role in PHF formation and self-aggregates most significantly in an aqueous solution of ...

journal_title：Biochemical and biophysical research communications

authors： Minoura K,Mizushima F,Tokimasa M,Hiraoka S,Tomoo K,Sumida M,Taniguchi T,Ishida T

更新日期：2005-02-25 00:00:00

abstract：:The phosphonodifluoromethyl phenylalanine (F2Pmp) is superior to phosphonomethyl phenylalanine (Pmp) as a non-hydrolyzable phosphotyrosine (pTyr) mimetic. The difluoromethyl moiety increases the inhibitory potency of a F2Pmp-containing peptide over a Pmp-containing counterpart by 1000-fold toward the protein tyrosine ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Wu L,Otaka A,Smyth MS,Roller PP,Burke TR Jr,den Hertog J,Zhang ZY

更新日期：1995-11-22 00:00:00

abstract：:Hepatic glucokinase is induced by insulin and repressed by glucagon. The effects of epidermal growth factor (EGF) on glucokinase expression were investigated in rat hepatocytes. EGF does not affect the decline in glucokinase activity in hepatocytes cultured for 48h in the absence of insulin, but it counteracts the inc...

journal_title：Biochemical and biophysical research communications

authors： Beresford GW,Agius L

更新日期：1994-06-15 00:00:00

abstract：:The posttranscriptional RNA editing by the type 1 adenosine deaminase acting on RNAs (ADAR1), expressed as p110 and p150 isoforms, is important for both physiological and pathological processes. Their expression and significance in leukemias remain unknown. Here, we investigated the expression of ADAR1 in Chinese pedi...

journal_title：Biochemical and biophysical research communications

authors： Ma CH,Chong JH,Guo Y,Zeng HM,Liu SY,Xu LL,Wei J,Lin YM,Zhu XF,Zheng GG

更新日期：2011-03-11 00:00:00

abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MA,Moore CX,Pittner R,Beaumont K

更新日期：1993-11-30 00:00:00

abstract：:Liver regeneration is controlled by multiple signaling pathways induced by a variety of growth factors, hormones, and cytokines. Here we report that protein kinase B (PKB)/Akt, part of a key cell survival signaling pathway, is markedly activated after partial hepatectomy (PHX). The antiapoptotic protein Bad, a downstr...

journal_title：Biochemical and biophysical research communications

authors： Hong F,Nguyen VA,Shen X,Kunos G,Gao B

更新日期：2000-12-29 00:00:00

abstract：:We previously showed that nuclear factor 1-A (NF1-A) binds to the silencer elements in the glutathione transferase P (GST-P) gene, and the carboxy terminal region of NF1-A represses the transcription activity of human metallothionein IIA (hMTIIA) promoter. In this study, we identified a repression region which is divi...

journal_title：Biochemical and biophysical research communications

authors： Osada S,Ikeda T,Xu M,Nishihara T,Imagawa M

更新日期：1997-09-29 00:00:00

abstract：:Dynamic shaping of the antibody repertoire is essential for effective immunity. We describe here a novel approach for clarifying how the antibody repertoire is shaped over time for development of a specific immune response. We obtained over 500 immunoglobulin G1 clones harboring VH186.2 from the spleen, bone marrow, a...

journal_title：Biochemical and biophysical research communications

authors： Furukawa A,Furukawa K,Azuma T

更新日期：2004-06-25 00:00:00

abstract：:To study the role of the cytoplasmic domain and particularly the tyrosine residues of the erythropoietin receptor (EpoR) in erythroid differentiation of human primary stem cells, we infected cord blood-derived CD34+ cells with retroviruses encoding chimeric receptors containing the extracellular domain of the prolacti...

journal_title：Biochemical and biophysical research communications

authors： Fichelson S,Chrétien S,Rokicka-Piotrowicz M,Bouhanik S,Gisselbrecht S,Mayeux P,Lacombe C

更新日期：1999-03-24 00:00:00

abstract：:Myxothiazol is a respiratory chain complex III (CIII) inhibitor that binds to the ubiquinol oxidation site Qo of CIII. It blocks electron transfer from ubiquinol to cytochrome b and thus inhibits CIII activity. It has been utilized as a tool in studies of respiratory chain function in in vitro and cell culture models....

journal_title：Biochemical and biophysical research communications

authors： Davoudi M,Kallijärvi J,Marjavaara S,Kotarsky H,Hansson E,Levéen P,Fellman V

更新日期：2014-04-18 00:00:00

abstract：:Estrogen deficiency-induced obesity has a high risk of visceral fat accumulation and body weight gain. It is also associated with many adverse health conditions. Taheebo extract from Tabebuia avellanedae has been recognized as playing several biological and pharmacological roles. Therefore, we investigated whether the...

journal_title：Biochemical and biophysical research communications

authors： Iwamoto K,Fukuda Y,Tokikura C,Noda M,Yamamoto A,Yamamoto M,Yamashita M,Zaima N,Iida A,Moriyama T

更新日期：2016-09-23 00:00:00

abstract：:A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI). In vitro studies were reported that activation of metabotropic glutamate receptor 5 (mGluR5) could inhibit the microglia-associated i...

journal_title：Biochemical and biophysical research communications

authors： Wang JW,Wang HD,Cong ZX,Zhang XS,Zhou XM,Zhang DD

更新日期：2013-01-18 00:00:00

abstract：:The activation of Kupffer cells represents a central mechanism of liver injury involving the production of TNF-alpha. It is known that glycine prevents LPS-induced production of TNF-alpha in isolated Kupffer cells. In this study, the possibility that glycine analogues might affect Kupffer cells was investigated. As a ...

journal_title：Biochemical and biophysical research communications

authors： Ishizaki-Koizumi S,Sonaka I,Takei Y,Ikejima K,Sato N

更新日期：2004-09-17 00:00:00

abstract：:We have obtained two new mAbs to the carboxy-terminal region of fibronectin, namely P3D4 and P1F11, and have studied their binding sites and their ability to block lymphocyte adhesion to fibronectin. ELISA and Western blot analyses showed that P3D4 reacts with both fibronectin chains and both Hep II-containing fragmen...

journal_title：Biochemical and biophysical research communications

authors： Garcia-Pardo A,Sánchez-Aparicio P,Wayner EA

更新日期：1992-07-15 00:00:00

abstract：:Six forms of cytochrome P-450 in the mitochondria of larvae from Musca domestica were isolated by solubilization with CHAPS followed by ammonium sulfate fractionation and HPLC on an anion-exchange column. Forms 1, 2, 3, 5, and 6 catalyzed the formation of 20-hydroxy-ecdysone from ecdysone in the presence of NADPH and ...

journal_title：Biochemical and biophysical research communications

authors： Srivatsan J,Weirich M,Agosin M

更新日期：1990-02-14 00:00:00

abstract：:GroEL-like particles of Thermus aquaticus are homo-oligomeric complexes of two stacked seven member rings, sedimenting in the gradient at 20S. The apparent molecular mass of the native particles is 820,000 (+/- 30,000). The protein complex is composed with one polypeptide of M(r) 59,000. Immunoblotting results and N-t...

journal_title：Biochemical and biophysical research communications

authors： Mikulík K,Benada O

更新日期：1993-12-15 00:00:00

abstract：:The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selective anti-herpes-virus compound. In order to synthesize and study the properties of a DNA that contains C-BVDU, the 5'-triphosphate, C-BVDUTP was prepared and evaluated as a potential substrate of the E. coli Klenow DNA...

journal_title：Biochemical and biophysical research communications

authors： Sági J,De Clercq E,Szemzö A,Csárnyi A,Kovács T,Otvös L

更新日期：1987-09-30 00:00:00

abstract：:Alpha 1-acid glycoprotein (AGP) complementary DNA clone has been isolated from an acute phase rabbit liver library. Complete and full-length nucleotide sequence of this cDNA has been determined. The cDNA contains 35 nucleotides 5' untranslated region followed by 606 nucleotides of coding region and a 112 nucleotides 3...

journal_title：Biochemical and biophysical research communications

authors： Ray BK,Ray A

更新日期：1991-07-31 00:00:00

abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

更新日期：2000-07-05 00:00:00

abstract：:We studied the subcellular distribution and the properties of [3H] mepyramine binding in the porcine vascular smooth muscle. A close correlation was observed between the specific binding activity of [3H] mepyramine and the extent of the enrichment of sarcolemmal marker enzyme in 4 subfractions obtained by sucrose dens...

journal_title：Biochemical and biophysical research communications

authors： Nishimura J,Kanaide H,Miwa N,Nakamura M

更新日期：1985-01-16 00:00:00

abstract：:Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. Mechanisms of antithrombin's effects on neutrophils were, therefore, studied by testing function and expression of heparan sulfate proteoglycans in RT-PCR or flow cytometry and cell migratio...

journal_title：Biochemical and biophysical research communications

authors： Kaneider NC,Egger P,Dunzendorfer S,Wiedermann CJ

更新日期：2001-09-14 00:00:00

abstract：:Mouse MARCKS is a prominent myristoylated alanine-rich C kinase substrate implicated in brain development, calcium/calmodulin signaling, and membrane cytoskeletal restructuring, and is developmentally regulated in a cell- and tissue-specific fashion. In this study, transcriptional regulation of mouse MARCKS promoter i...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Liu X,Lenox RH

更新日期：2002-04-12 00:00:00

abstract：:The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orient...

journal_title：Biochemical and biophysical research communications

authors： Choi HK,Huang SK,Bau R

更新日期：1988-11-15 00:00:00

abstract：:Six missense mutations in human cardiac troponin I (cTnI) were recently found to cause restrictive cardiomyopathy (RCM). We have bacterially expressed and purified these human cTnI mutants and examined their functional and structural consequences. Inserting the human cTnI into skinned cardiac muscle fibers showed that...

journal_title：Biochemical and biophysical research communications

authors： Yumoto F,Lu QW,Morimoto S,Tanaka H,Kono N,Nagata K,Ojima T,Takahashi-Yanaga F,Miwa Y,Sasaguri T,Nishita K,Tanokura M,Ohtsuki I

更新日期：2005-12-23 00:00:00