Epidermal growth factor counteracts insulin-induced expression of glucokinase in hepatocytes.


:Hepatic glucokinase is induced by insulin and repressed by glucagon. The effects of epidermal growth factor (EGF) on glucokinase expression were investigated in rat hepatocytes. EGF does not affect the decline in glucokinase activity in hepatocytes cultured for 48h in the absence of insulin, but it counteracts the increase in activity induced by insulin. This effect of EGF is greater in cells cultured at low cell density than in confluent cultures. EGF suppressed the insulin-induced increase in glucokinase mRNA levels by 50% indicating that its effect is at least in part at a pretranslational level. However, it potentiated the stimulatory effect of insulin on glucose-6-phosphate dehydrogenase activity and mRNA, indicating that the effect on glucokinase expression is due to a specific post-receptor mechanism. The effect of EGF on glucokinase mRNA expression is mimicked by phospholipase D but not by phosphatidylinositol-specific phospholipase C or by phorbol ester, an activator of protein kinase C, suggesting that it is unlikely to be mediated by activation of protein kinase C.


Beresford GW,Agius L




Has Abstract


1994-06-15 00:00:00














  • Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

    abstract::The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

    更新日期:2011-08-12 00:00:00

  • Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system.

    abstract::TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the characteristics of two TRPA1 paralogs of zebrafish (zTRPA1a, b) and demonstrated that zTRPA1a ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Oda M,Saito K,Hatta S,Kubo Y,Saitoh O

    更新日期:2017-12-09 00:00:00

  • Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.

    abstract::In the yeast Saccharomyces cerevisiae, Ca(2+) signaling mediated by the Ca(2+)/calmodulin dependent phosphatase, calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the Crz1p ("crazy") transcripti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Cyert MS

    更新日期:2003-11-28 00:00:00

  • Roles of four iron centers in Paracoccus halodenitrificans nitric oxide reductase.

    abstract::Reactions of Paracoccus halodenitrificans nitric oxide reductase (NOR) containing four iron centers, a low spin hemec, a low spin heme b, a high spin heme b and a non-heme iron, have been studied to show the roles of each iron center. Soon after reacting the resting (oxidized) NOR with L-ascorbate, the low spin heme c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sakurai T,Sakurai N,Matsumoto H,Hirota S,Yamauchi O

    更新日期:1998-10-09 00:00:00

  • Phospholipase C mimics tumor promoter-induced chemiluminescence in murine epidermal cells.

    abstract::Treatment of newborn murine epidermal cells with phospholipase C results in the generation of a chemiluminescence response similar to that previously described for phorbol ester tumor promoters. Based on inhibitor studies, the oxidant, believed to be superoxide anion, is most likely generated from lipoxygenase metabol...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fischer SM,Baldwin JK,Adams LM

    更新日期:1985-09-30 00:00:00

  • The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis.

    abstract::Transforming growth factor (TGF)-beta1 can cause fibrosis diseases by enhancing production of collagen. However, the intracellular signaling mechanism for TGF-beta1 stimulation of this process has not been fully elucidated. The present study focused on this mechanism and the cross-talk between the MAPK and Smad pathwa...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li F,Zeng B,Chai Y,Cai P,Fan C,Cheng T

    更新日期:2009-08-21 00:00:00

  • Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats.

    abstract::Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yin N,Yao X,Zhou Q,Faiola F,Jiang G

    更新日期:2015-03-06 00:00:00

  • miR-410-3p promotes prostate cancer progression via regulating PTEN/AKT/mTOR signaling pathway.

    abstract::Prostate cancer has become one of commonest urologic tumors in male. In recent years, miRNAs are continually attracting attentions of researchers for their special regulatory function in human cancers. Previous study has revealed that miR-410 acts as a biomarker for the diagnosis of prostate cancer. Whereas, the speci...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang Y,Zhang D,Lv J,Wang S,Zhang Q

    更新日期:2018-09-18 00:00:00

  • A strategy of targeting B10 cell by CD19scFv-IL10R for tumor therapy.

    abstract::IL-10 producing B (B10) cells, a subset of regulatory B (Breg) cells, produce IL-10 and play immunosuppressive roles in antitumor immunity. B10 cells are associated with enhanced tumor-aggressiveness and a poorer prognosis. To specifically inhibit the IL-10 secreted by B cells, we constructed the recombinant plasmid p...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhao R,Liu M,Li X,Chen H,Deng J,Huang C,Zhang XL,Pan Q

    更新日期:2018-12-02 00:00:00

  • Cloning and characterization of the 5'-flanking region of the human dopamine D4 receptor gene.

    abstract::Dopamine D4 receptor (DRD4) has received attention in terms of pathogenesis of schizophrenia and association with human personalities. We isolated the human DRD4 gene containing the 5'-flanking region and determined its sequence. Analysis of the DRD4 transcripts by 5'-RACE (5'-rapid amplification of cDNA ends) reveale...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kamakura S,Iwaki A,Matsumoto M,Fukumaki Y

    更新日期:1997-06-18 00:00:00

  • Mechanism involved in the antiplatelet activity of naloxone in human platelets.

    abstract::In this study, naloxone was tested for its antiplatelet activity in human platelet suspensions. In platelet suspensions (4.5 x 10(8)/ml), naloxone (0.1-0.5 mM) significantly inhibited platelet aggregation and ATP-release stimulated by various agonists (i.e., thrombin, collagen, U46619, and ADP). Furthermore, naloxone ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sheu JR,Hung WC,Lee LW,Chang PT,Kan YC,Yen MH

    更新日期:1997-02-03 00:00:00

  • Enhancement of tubulin polymerization by Cl(-)-induced blockade of intrinsic GTPase.

    abstract::In growing neurite of neuronal cells, it is suggested that α/β-tubulin heterodimers assemble to form microtubule, and assembly of microtubule promotes neurite elongation. On the other hand, recent studies reveal importance of intracellular Cl(-) in regulation of various cellular functions such as cell cycle progressio...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Nakajima K,Niisato N,Marunaka Y

    更新日期:2012-08-24 00:00:00

  • Negative and positive elements in the promoter region of the human apoferritin L gene.

    abstract::We have characterized the promoter of the human gene coding for the apoferritin L subunit. Transient transfections of 5' and 3' deletion mutants indicate that the efficiency of the L promoter depends on both negative and positive cis-elements, located upstream and downstream of the transcription start point. DNaseI fo...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: D'Agostino P,Faniello MC,Quaresima B,Bevilacqua MA,Tiano MT,Ammendola R,Cimino F,Costanzo F

    更新日期:1995-10-04 00:00:00

  • Stimulation of calcium entry is prerequisite for DNA synthesis induced by platelet-derived growth factor in vascular smooth muscle cells.

    abstract::The present study was conducted to determine a role of calcium entry in the growth promoting action of platelet-derived growth factor (PDGF) in cultured rat vascular smooth muscle cells. Addition of PDGF to quiescent cells induced a rapid elevation of cytoplasmic free calcium concentration, [Ca2+]c, followed by a sust...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mogami H,Kojima I

    更新日期:1993-10-29 00:00:00

  • A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Liver X receptor (LXR) alpha is known to be involved in the control of cholesterol homeostasis. Thus, the purpose of this study was to investigate the effects of 3-methlycholanthrene (MC), one of the PAHs, on LXRalp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Iwano S,Nukaya M,Saito T,Asanuma F,Kamataki T

    更新日期:2005-09-16 00:00:00

  • Cafeteria diet-induced obesity causes oxidative damage in white adipose.

    abstract::Obesity continues to be one of the most prominent public health dilemmas in the world. The complex interaction among the varied causes of obesity makes it a particularly challenging problem to address. While typical high-fat purified diets successfully induce weight gain in rodents, we have described a more robust mod...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Johnson AR,Wilkerson MD,Sampey BP,Troester MA,Hayes DN,Makowski L

    更新日期:2016-04-29 00:00:00

  • Crystallization and preliminary crystallographic analysis of manganese superoxide dismutase from Bacillus halodenitrificans.

    abstract::Manganese superoxide dismutase (GP-MnSOD), a component of the so-called 'green protein' (green protein complex) from the facultative anaerobic halodenitrifier Bacillus halodenitrificans, has been crystallized using the hanging-drop vapor diffusion method. Crystals have unit-cell parameters a=b=93.4 A, c=65.0 A, and be...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Liao J,Li M,Liu MY,Chang T,Le Gall J,Gui LL,Zhang JP,Liang DC,Chang WR

    更新日期:2002-05-31 00:00:00

  • Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy.

    abstract::Humoral hypercalcemia of malignancy (HHM) occurs when secretion of parathyroid hormone-related peptide (PTHrP) by cancer cells causes hypercalcemia in the absence of skeletal metastases. High extracellular calcium (Ca(2+)(o)) increases secretion of PTH-like bioactivity by rat H-500 leydig cells, a transplantable model...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sanders JL,Chattopadhyay N,Kifor O,Yamaguchi T,Brown EM

    更新日期:2000-03-16 00:00:00

  • The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis.

    abstract::Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of neutrophils, macrophages and T cells. These cells are a key component of inflammation and all express BLT1, a high affinity G-protein-coupled receptor for LTB(4). However, little is known about the neuroimmune functions of BLT1. In this study, we d...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kihara Y,Yokomizo T,Kunita A,Morishita Y,Fukayama M,Ishii S,Shimizu T

    更新日期:2010-04-09 00:00:00

  • A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas.

    abstract::Isocitrate dehydrogenase 1 (IDH1) mutations have been detected in gliomas and other tumors. Although IDH1 catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in cytosol, mutated IDH1 proteins possess the ability to change α-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Several mono...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fujii Y,Ogasawara S,Oki H,Liu X,Kaneko MK,Takano S,Kato Y

    更新日期:2015-10-30 00:00:00

  • Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes.

    abstract::Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its systemic effects, cellular functions of membranous DPP-4 are less clear. Here we studied the role of DPP-4 in hepatic energy metabolism. In order to distinguish sys...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rufinatscha K,Radlinger B,Dobner J,Folie S,Bon C,Profanter E,Ress C,Salzmann K,Staudacher G,Tilg H,Kaser S

    更新日期:2017-04-01 00:00:00

  • Partial dependency of 1-oleoyl-2-acetyl-glycerol-induced superoxide production by human neutrophils on calcium ions and cytochalasin B.

    abstract::Superoxide production by neutrophils induced by 1-oleoyl-2-acetyl-sn-glycerol at concentrations below 100 microM was enhanced by extracellular calcium ions, while that of phorbol myristate acetate was unaffected. Verapamil, a calcium-channel blocker, more effectively inhibited the superoxide production induced by 1-ol...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ozaki Y,Kume S,Ohashi T,Niwa Y

    更新日期:1986-01-29 00:00:00

  • IL-1 beta-dependent regulation of C/EBP delta transcriptional activity.

    abstract::We have previously shown that the transcription factor C/EBP delta is involved in the intestinal inflammatory response. C/EBP delta regulates several inflammatory response genes, such as haptoglobin, in the rat intestinal epithelial cell line IEC-6 in response to IL-1. However, the different C/EBP delta domains involv...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Svotelis A,Doyon G,Bernatchez G,Désilets A,Rivard N,Asselin C

    更新日期:2005-03-11 00:00:00

  • Effects of a protein kinase C inhibitor, K-252a, on human polymorphonuclear neutrophil responsiveness.

    abstract::We investigated the capacity of K-252a, an inhibitor of rat brain protein kinase C (PKC), to influence polymorphonuclear neutrophil (PMN) PKC and PMN activation with chemically and structurally dissimilar agonists. K-252a inhibited PMN PKC (IC50 = 0.58 microM), and caused a concentration-dependent (0.1-10 microM) inhi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Smith RJ,Justen JM,Sam LM

    更新日期:1988-05-16 00:00:00

  • MicroRNA-26a modulates transforming growth factor beta-1-induced proliferation in human fetal lung fibroblasts.

    abstract::MicroRNA-26a is a newly discovered microRNA that has a strong anti-tumorigenic capacity and is capable of suppressing cell proliferation and activating tumor-specific apoptosis. However, whether miR-26a can inhibit the over-growth of lung fibroblasts remains unclear. The relationship between miR-26a and lung fibrosis ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li X,Liu L,Shen Y,Wang T,Chen L,Xu D,Wen F

    更新日期:2014-11-28 00:00:00

  • Modification of soybean sucrose synthase by S-thiolation with ENOD40 peptide A.

    abstract::The gene ENOD40 is expressed at an early stage of root nodule organogenesis and has been postulated to play a central regulatory role in the Rhizobium-legume interaction. In vitro translation of soybean ENOD40 mRNA showed that the gene encodes two peptides of 12 and 24aa residues (peptides A and B) that bind to sucros...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Röhrig H,John M,Schmidt J

    更新日期:2004-12-17 00:00:00

  • Effects of folic acid deficiency and MTHFRC677T polymorphisms on cytotoxicity in human peripheral blood lymphocytes.

    abstract::Apoptosis (APO) and necrosis (NEC) are two different types of cell death occurring in response to cellular stress factors. Cells with DNA damage may undergo APO or NEC. Folate is an essential micronutrient associated with DNA synthesis, repair and methylation. Methylenetetrahydrofolate reductase (MTHFR) regulates intr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wu X,Liang Z,Zou T,Wang X

    更新日期:2009-02-13 00:00:00

  • Major role of the histones H3-H4 in the folding of the chromatin fiber.

    abstract::We have characterized the hydrodynamic behavior of nucleosome arrays in which the N- and C-terminal "tails" of the histone H2A-H2B and H3-H4 domains have been selectively removed by digestion with immobilized trypsin. The sedimentation coefficient of the polynucleosome fibers lacking the histone H2A-H2B tails exhibite...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Moore SC,Ausió J

    更新日期:1997-01-03 00:00:00

  • Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart.

    abstract:RATIONALE:Islet-1 positive (Islet-1(+)) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta and pulmonary arte...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Weinberger F,Mehrkens D,Starbatty J,Nicol P,Eschenhagen T

    更新日期:2015-01-02 00:00:00

  • Marked rapid alterations in nocturnal pineal serotonin metabolism in mice and rats exposed to weak intermittent magnetic fields.

    abstract::Adult AMES mice and male Sprague Dawley rats were exposed to an artificial magnetic field, generated by Helmholtz coils. 3.5 hours after the onset of darkness the coils were activated for one hour resulting in an inversion of the horizontal component of the earth's magnetic field. The coils were activated and deactiva...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lerchl A,Nonaka KO,Stokkan KA,Reiter RJ

    更新日期:1990-05-31 00:00:00