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Octahedral complexes of anti-cancer Pt(IV)(cyclohexyldiamine) agents with 9-methylguanine.

Abstract：

:The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orientations of the guanine rings as compared to their corresponding Pt(II) counterparts.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Choi HK,Huang SK,Bau R

doi

10.1016/s0006-291x(88)80749-6

subject

Has Abstract

pub_date

1988-11-15 00:00:00

pages

1125-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80749-6

journal_volume

156

pub_type

杂志文章

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