当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.

Abstract：

:Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress. In the present study, we investigated the molecular mechanisms by which quercetin affects adipogenesis and apoptosis in 3T3-L1 cells. The exposure of 3T3-L1 preadipocytes to quercetin resulted in attenuated adipogenesis and decreased expression of adipogenesis-related factors and enzymes. Moreover, quercetin exposure up-regulated the levels of phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase (ACC). Treatment of 3T3-L1 adipocytes with quercetin resulted in the induction of apoptosis and a concomitant decrease in ERK and JNK phosphorylation. Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ahn J,Lee H,Kim S,Park J,Ha T

doi

10.1016/j.bbrc.2008.06.077

subject

Has Abstract

pub_date

2008-09-05 00:00:00

pages

545-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01218-7

journal_volume

373

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • CYP4T1--a cytochrome P450 expressed in rainbow trout (Oncorhynchus mykiss) liver.

    abstract：:Total RNA isolated from a rainbow trout (Oncorhynchus mykiss) liver was subjected to RT/PCR using degenerate primers designed from homologous regions amongst cytochrome P450 CYP4 proteins. PCR amplification resulted in a single electrophoretic band which was excised, purified and sequenced directly, using cycle sequen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6957

    authors： Falckh PH,Wu QK,Ahokas JP

    更新日期：1997-07-18 00:00:00

  • Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice.

    abstract：:Idiopathic epilepsy is characterized by seizures without a clear etiology and is believed to have a strong genetic component but exhibits a complex inheritance pattern. Genetic factors seem to confer a low seizure threshold to susceptible individuals and thereby enhance epileptogenesis. However, the identity of suscep...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.02.056

    authors： Bae YS,Chung W,Han K,Park KY,Kim H,Kim E,Kim MH

    更新日期：2013-04-05 00:00:00

  • Molecular basis of bird respiration: primary hemoglobin structure component from Tufted duck (Aythya fuligula, Anseriformes)--role of alpha99Arg in formation of a complex salt bridge network.

    abstract：:The primary structure of the major hemoglobin component, HbA (alpha(A)- and beta-chain), from Tufted duck (Aythya fuligula) is presented. The separation of the globin subunits was achieved by ion exchange chromatography on CM-cellulose in 8 M urea. The amino acid sequence was determined by automatic Edman degradation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6399

    authors： Abbasi A,Lutfullah G

    更新日期：2002-02-15 00:00:00

  • Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1.

    abstract：:Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circad...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.131

    authors： Oiwa A,Kakizawa T,Miyamoto T,Yamashita K,Jiang W,Takeda T,Suzuki S,Hashizume K

    更新日期：2007-02-23 00:00:00

  • Tankyrase promotes primary precursor miRNA processing to precursor miRNA.

    abstract：:Tankyrases (TNKS and TNKS2) are members of poly(ADP-ribose) polymerase (PARP) family proteins. Tankyrase has multiple ankyrin repeat cluster (ARC) domains, which recognize the tankyrase-binding motifs in proteins including the telomeric protein, TRF1 and Wnt signal regulators, AXINs. However, the functional significan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.191

    authors： Mizutani A,Seimiya H

    更新日期：2020-02-19 00:00:00

  • Visual screening for localized RNAs in yeast revealed novel RNAs at the bud-tip.

    abstract：:Several RNAs, including rRNAs, snRNAs, snoRNAs, and some mRNAs, are known to be localized at specific sites in a cell. Although methods have been established to visualize RNAs in a living cell, no large-scale visual screening of localized RNAs has been performed. In this study, we constructed a genomic library in whic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.139

    authors： Andoh T,Oshiro Y,Hayashi S,Takeo H,Tani T

    更新日期：2006-12-29 00:00:00

  • An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin.

    abstract：:Trichosanthin (TCS) is a type I ribosome-inactivating protein possessing multiple biological and pharmacological activities. One of its major actions is inhibition of human immunodeficiency virus (HIV) replication. The mechanism is still not clear. It is generally believed that this action is mediated via ribosome ina...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.004

    authors： Ouyang DY,Chan H,Wang YY,Huang H,Tam SC,Zheng YT

    更新日期：2006-01-06 00:00:00

  • E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.

    abstract：BACKGROUND:Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. METHODS AND RESULTS:In this st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.023

    authors： Yamamoto H,Kuroda N,Uekita H,Kochi I,Matsumoto A,Niinaga R,Funahashi T,Shimomura I,Kihara S

    更新日期：2016-02-05 00:00:00

  • Involvement of hepatocyte growth factor in formation of bronchoalveolar structures in embryonic rat lung in primary culture.

    abstract：:To clarify the role of hepatocyte growth factor (HGF) in embryonic lung development, organoids from fetal rat lung were cultured in collagen gels with or without HGF antisense oligonucleotides. Cyst-like structures formed within 24 h in organoids isolated from fetuses after 14 days' gestation, but this was abolished b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7526

    authors： Itakura A,Kurauchi O,Morikawa S,Okamura M,Furugori K,Mizutani S

    更新日期：1997-12-08 00:00:00

  • Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists.

    abstract：:Kinetics of association--dissociation, competition and chromatography on two different resins, all revealed the presence of a new binding site which: specifically accepts 7-alpha-propyl spirolactone (3H-RU-26752), has little affinity for aldosterone, is present only in the target tissue (rat kidney), and is wanting in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90556-5

    authors： Lazar G,Agarwal MK

    更新日期：1986-01-14 00:00:00

  • Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2.

    abstract：:Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.11.026

    authors： Whitson RH,Tsark W,Huang TH,Itakura K

    更新日期：2003-12-26 00:00:00

  • The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation.

    abstract：:alpha 2,6 sialyltransferase towards the N-acetyllactosaminyl sequence (alpha 2,6 ST, E.C. 2.4.99.1) is one of the major sialyltransferases in human colonic cells; it strongly increases in human colorectal tumors and is largely expressed in fetal and neonatal rat colon. In this study we demonstrate that human colon car...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80039-7

    authors： Dall'Olio F,Malagolini N,Serafini-Cessi F

    更新日期：1992-05-15 00:00:00

  • Transforming growth factor-beta inhibits endothelial cell proliferation.

    abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91209-x

    authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

    更新日期：1986-05-29 00:00:00

  • Fluorescent probing with felodipine of the dihydropyridine receptor and its interaction with the ryanodine receptor calcium release channel.

    abstract：:The intensity of the fluorescence emission of the fluorescent 1,4-dihydropyridine (DHP) derivative felodipine increased upon binding to both isolated cardiac sarcolemma (SLM) and skeletal muscle sarcoplasmic reticulum (SR) preparations, the latter containing SR-transversal tubule junctional diads and triads. The fluor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8233

    authors： Minarovic I,Mészáros LG

    更新日期：1998-03-17 00:00:00

  • Mechanism of activation of branched-chain alpha-keto acid dehydrogenase complex by exercise.

    abstract：:Branched-chain alpha-keto acid dehydrogenase (BCKDH) complex catalyzes the committed step of branched-chain amino acid catabolism, and its activity is regulated by the phosphorylation-dephosphorylation cycle. BCKDH kinase is responsible for inactivation of the complex by phosphorylation. In the present study, we exami...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5647

    authors： Xu M,Nagasaki M,Obayashi M,Sato Y,Tamura T,Shimomura Y

    更新日期：2001-09-28 00:00:00

  • α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

    abstract：:Fut8 (α1,6-Fucosyltransferase) heterozygous knock-out (Fut8(+/-)) mice had an increased influx of inflammatory cells into the lungs, and this was associated with an up-regulation of matrix metalloproteinases, MMP-2 and MMP-9, after treatment with porcine pancreatic elastase (PPE), exhibiting an emphysema-prone phenoty...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.081

    authors： Kamio K,Yoshida T,Gao C,Ishii T,Ota F,Motegi T,Kobayashi S,Fujinawa R,Ohtsubo K,Kitazume S,Angata T,Azuma A,Gemma A,Nishimura M,Betsuyaku T,Kida K,Taniguchi N

    更新日期：2012-07-20 00:00:00

  • Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.

    abstract：:Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, can modulate pyruvate oxidation in mitochondrial and MPC1 expression correlates with poor prognosis of multiple cancers. Here, we reported that MPC1 is acetylated and its main acetylation sites are: K45 and K46. Sirt3 binds to and deacetylates MPC1. High...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.11.036

    authors： Liang L,Li Q,Huang L,Li D,Li X

    更新日期：2015-12-25 00:00:00

  • DMSO inhibits human platelet activation through cyclooxygenase-1 inhibition. A novel agent for drug eluting stents?

    abstract：BACKGROUND:DMSO is routinely infused together with hematopoietic cells in patients undergoing myeloablative therapy and was recently found to inhibit smooth muscle cells proliferation and arterial thrombus formation in the mouse by preventing tissue factor (TF), a key activator of the coagulation cascade. This study wa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.102

    authors： Asmis L,Tanner FC,Sudano I,Lüscher TF,Camici GG

    更新日期：2010-01-22 00:00:00

  • The acidic domain of hnRNPQ (NSAP1) has structural similarity to Barstar and binds to Apobec1.

    abstract：:Apobec1 edits the ApoB mRNA by deaminating nucleotide C(6666), which results in a codon change from Glutamate to stop, and subsequent expression of a truncated protein. Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.09.044

    authors： Quaresma AJ,Oyama S Jr,Barbosa JA,Kobarg J

    更新日期：2006-11-17 00:00:00

  • VEGF/CDK2 are involved in diabetic organ regeneration.

    abstract：AIM/HYPOTHESIS:Diabetes is a hyperglycaemic disease treated by a set of allopathic drugs and natural biomolecules along with many variety of stem cell. We aim to investigate the role of these drugs in targeting common protein molecule in diabetes and its associated disease. We also aim to investigate the organ degenera...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.07.014

    authors： Ambasta RK,Adeshara K,Yadav S,Kumar P

    更新日期：2020-09-03 00:00:00

  • Enzyme-linked immunosorbent assay of nucleic acid sequence-based amplification for molecular detection of M. tuberculosis.

    abstract：:An enzyme-linked immunosorbent assay of nucleic acid sequence-based amplification (NASBA-ELISA) was developed for molecular detection of Mycobacterium tuberculosis. The primers targeting 16S rRNA were used for the amplification of bacterial RNA by the isothermal digoxigenin (DIG)-labeling NASBA process, resulting in t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.039

    authors： Gill P,Ramezani R,Amiri MV,Ghaemi A,Hashempour T,Eshraghi N,Ghalami M,Tehrani HA

    更新日期：2006-09-08 00:00:00

  • Molecular cloning of rat liver glucocorticoid-receptor translocation promoter.

    abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1703

    authors： Okamoto K,Hirano H,Isohashi F

    更新日期：1993-06-30 00:00:00

  • Divergent effects of filamin and tropomyosin on actin filaments bundling.

    abstract：:Filamin increases and tropomyosin decreases the susceptibility of F-actin to form bundles of filaments in the presence of polyethylene glycol 6000. The two proteins, which are located in the leading edge and in the internal part of the cell, respectively, are thus likely to display divergent effects on the microfilame...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90637-3

    authors： Grazi E,Trombetta G,Guidoboni M

    更新日期：1990-03-30 00:00:00

  • Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.

    abstract：:FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.119

    authors： Qian Y,Xia S,Feng Z

    更新日期：2017-01-29 00:00:00

  • Atrial natriuretic polypeptide in atria and plasma in experimental hyperthyroidism and hypothyroidism.

    abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90544-9

    authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

    更新日期：1986-01-14 00:00:00

  • Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay.

    abstract：:The maintenance of telomere length is crucial for survival of cells. Telomerase is an RNA-containing reverse transcriptase, which is responsible for elongation of shortened telomeres. Telomerase reactivation has been suggested to be involved in malignant progressions. To study on the involvement of telomerase activati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8487

    authors： Miura M,Karasaki Y,Abe T,Higashi K,Ikemura K,Gotoh S

    更新日期：1998-05-08 00:00:00

  • Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.

    abstract：:Neurosteroids are endogenously derived compounds, mediating rapid effects in the central nervous system. They participate in vital processes, including memory and learning, neuroplasticity, and neuroprotection in Alzheimer's disease. However, the mechanisms behind those effects remain to be elucidated. The neurosteroi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.055

    authors： Elfverson M,Linde AM,Le Grevès P,Zhou Q,Nyberg F,Johansson T

    更新日期：2008-07-25 00:00:00

  • Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide.

    abstract：:8-Hydroxyguanine (8-OH-Gua) residues were formed in DNA of Ehrlich ascites cells exposed to the carcinogen 4-nitroquinoline 1-oxide. Formation of 8-OH-Gua was confirmed by chemical treatment of calf thymus DNA with the proximate metabolite of this carcinogen, 4-hydroxyaminoquinoline 1-oxide, together with seryl-adenos...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80036-5

    authors： Kohda K,Tada M,Kasai H,Nishimura S,Kawazoe Y

    更新日期：1986-09-14 00:00:00

  • Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium.

    abstract：:Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. Here we show that exposure of human airway epithelial cells to cadmium promotes a polarized ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.096

    authors： Rennolds J,Malireddy S,Hassan F,Tridandapani S,Parinandi N,Boyaka PN,Cormet-Boyaka E

    更新日期：2012-01-06 00:00:00

  • Evidence for alternative RNA splicing and possible alternative promoters in the human muscle phosphofructokinase gene at the 5' untranslated region.

    abstract：:Three mRNA species for human muscle phophofructokinase containing heterogeneous 5' untranslated sequences were identified through cDNA cloning. Type A mRNA was essentially the same as that reported previously (Nakajima, H., et al. (1987) FEBS Lett. 223, 113). Type B mRNA was considered to be the major gene product, wh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90856-i

    authors： Nakajima H,Yamasaki T,Noguchi T,Tanaka T,Kono N,Tarui S

    更新日期：1990-01-30 00:00:00