Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide.

abstract：:Cytochrome P450 enzymes (CYP enzymes) catalyse the initial step in biotransformation of xenobiotics like polycyclic aromatic hydrocarbons (PAHs). The marine polychaete Nereis virens has a high capacity for biotransformation of PAHs. In the present study, the complete cDNA sequences of two novel CYP genes isolated from...

journal_title：Biochemical and biophysical research communications

authors： Jørgensen A,Rasmussen LJ,Andersen O

更新日期：2005-10-28 00:00:00

abstract：:RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3. It contains a distinct SET domain, sometimes referred to as PR (PRDI-BF1 and RIZ1 homology) domain, that is responsible for its catalytic activity. We determined the solution structure of the PR domain from R...

journal_title：Biochemical and biophysical research communications

authors： Briknarová K,Zhou X,Satterthwait A,Hoyt DW,Ely KR,Huang S

更新日期：2008-02-15 00:00:00

abstract：:Trichosanthin (TCS) is a type I ribosome-inactivating protein that inhibits the replication of both human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). The mechanism of inhibition is not clear. This investigation explored the effects of TCS on the stages of HSV-1 infection in Hep-2 cel...

journal_title：Biochemical and biophysical research communications

authors： He DX,Tam SC

更新日期：2010-11-26 00:00:00

abstract：:A cDNA for murine transcription factor S-II (Hirashima et al., J. Biol. Chem (1988) 263, 3858-3863) was inserted into a silkworm baculovirus vector and expressed in Bm-N cells, a cell line of Bombyx mori maintained in the laboratory. Recombinant S-II was purified from virus-infected cell extracts to near homogeneity b...

journal_title：Biochemical and biophysical research communications

authors： Hirashima S,Horikoshi N,Sekimizu K,Natori S

更新日期：1989-05-15 00:00:00

abstract：:The fate of [125I] lactoferrin after binding on its specific receptor on HT29-D4 cells, a clone of HT29 cells, was studied and compared with that of [125I]transferrin. Time courses of protein binding in relation with temperature clearly show that different mechanisms of ligand-transportation for the two glycoproteins ...

journal_title：Biochemical and biophysical research communications

authors： Roiron-Lagroux D,Figarella C

更新日期：1990-07-31 00:00:00

abstract：:HOX genes are transcription factors that play important roles in body patterning and many cellular processes during embryonic, fetal, and adult development. Given their important function in normal tissues, it is reasonable to assume that abnormal expression of HOX genes in adults could lead to serious diseases such a...

journal_title：Biochemical and biophysical research communications

authors： Lee JY,Kim JM,Jeong DS,Kim MH

更新日期：2018-09-18 00:00:00

abstract：:The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inh...

journal_title：Biochemical and biophysical research communications

authors： Chambers JE,Munson JR,Chambers HW

更新日期：1989-11-30 00:00:00

abstract：:The reactivation of mitochondrial ATPase by acidic and isoelectric phospholipids was studied comparatively with two purified enzyme preparations exhibiting different gel electrophoretic patterns: the preparation of Serrano et al. (1976, J. Biol. Chem. 251, 2453-2461) and the complex V of Galante et al. (1979, J. Biol....

journal_title：Biochemical and biophysical research communications

authors： Dabbeni-Sala F,Palatini P

更新日期：1985-12-17 00:00:00

abstract：:Functional endothelial cells and their progenitors are required for vascular development, adequate vascular function, vascular repair and for cell-based therapies of ischemic diseases. Currently, cell therapy is limited by the low abundance of patient-derived cells and by the functional impairment of autologous endoth...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Eligehausen S,Stehling M,Nikol S,Ko K,Waltenberger J,Klocke R

更新日期：2014-01-10 00:00:00

abstract：:Glucose depressed DNA synthesis in rat hepatocytes in primary culture. As compared to controls cultured with 5.6 mM glucose, maximal (> or = 75%) inhibition was obtained at 20-30 mM, and half-maximal effect at 10-15 mM. Comparison of D- and L-glucose showed that the effect was specific for the D-form. Maximal inhibiti...

journal_title：Biochemical and biophysical research communications

authors： Dajani OF,Refsnes M,Guren TK,Horn RS,Thoresen GH,Christoffersen T

更新日期：1994-08-15 00:00:00

abstract：:In malate dehydrogenase from Thermus flavus, substitution of Ile for Thr189, which is involved in hydrogen-bond network around a loop containing catalytic His186, caused an increase in the turnover number at room temperatures. In order to examine the effect of disruption of the hydrogen bonds on the catalytic activity...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama M,Kinoshita M,Kudo H,Horinouchi S,Tanokura M

更新日期：1996-08-23 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) had been proved to be pivotal regulators in carcinogenesis. On the basis of competitive endogenous RNAs (ceRNAs) system, lncRNAs significantly expanded their regulating networks. In our research, we aimed to figure out the exact role of lncRNA HNF1A-AS1 in the pathogenesis of hepatocellu...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Wei X,Zhang A,Li C,Bai J,Dong J

更新日期：2016-05-13 00:00:00

abstract：:The nonapeptide Cys-Tyr-Cys-Gln-Asp-Pro-Tyr-Val-Lys was prepared by solid-phase peptide synthesis under oxidizing conditions. Fast atom bombardment mass spectrometric analysis of the untreated molecule produced an ion consistent with a structure involving an intramolecular disulfide bond between Cys(1) and Cys(3). Mas...

journal_title：Biochemical and biophysical research communications

authors： Pramanik B,Tsarbopoulos A,Labdon JE,Czarniecki M,Nagabhushan TL,Trotta PP

更新日期：1988-12-15 00:00:00

abstract：:Previously, we have demonstrated evidence suggesting that SUMO4 negatively regulates NFkappaB transcriptional activity, probably through sumoylation of IkappaBalpha. Here, we present data indicating that SUMO4 possesses the capacity to conjugate to IkappaBalpha. Luciferase reporter assays in 3T3 cells deficient for Ik...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Yang P,Li M,Gong F

更新日期：2009-04-17 00:00:00

abstract：:In this report we demonstrate formation of a triplex structure by an antiparallel RNA oligonucleotide corresponding to the 21 bp polypurine-pyrimidine stretch from -141 to -162 of the rat alpha 1(I) procollagen promoter with a Kd of 0.1-0.2 microM. The formation of triplexes by the triplex forming oligoribonucleotide ...

journal_title：Biochemical and biophysical research communications

authors： Ririe SS,Guntaka RV

更新日期：1998-08-10 00:00:00

abstract：:p73 is a member of the p53 family of transcription factors which plays an essential role in tumor suppression. p73 is associated with the sensitivity of cancer cells to chemotherapy and the prognosis of many cancers. In this study, we showed the ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiqu...

journal_title：Biochemical and biophysical research communications

authors： Min B,Ryu J,Chi SW,Yi GS

更新日期：2015-11-13 00:00:00

abstract：:We have developed a charge-mediated fusion method to reconstitute the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in giant unilamellar vesicles (GUV). Intracellular Ca2+ transport by SERCA controls key processes in human cells such as proliferation, signaling, and contraction. Small-molecule effectors of SERCA are...

journal_title：Biochemical and biophysical research communications

authors： Bian T,Autry JM,Casemore D,Li J,Thomas DD,He G,Xing C

更新日期：2016-12-09 00:00:00

abstract：:GMP-140 (CD62; PADGEM) is a member of the selectin family expressed highly at the surface of platelets and endothelial cells by agonists such as thrombin or phorbol esters. Previous studies indicate that the lectin domain of GMP-140 recognizes sialosyl-Le(x) (SLex) and to a lesser extent Le(x) (Polley MJ, et al., Proc...

journal_title：Biochemical and biophysical research communications

authors： Handa K,Nudelman ED,Stroud MR,Shiozawa T,Hakomori S

更新日期：1991-12-31 00:00:00

abstract：:Porins are trimeric proteins in the outer membranes of Gram-negative bacteria. Several of them, among them matrix porin of Escherichia coli, form symmetrically voltage-gated ion channels in planar bilayers. Trimers exhibit negative resistance at potentials larger than +/- 90mV. Here we show that, after two pores withi...

journal_title：Biochemical and biophysical research communications

authors： Buehler LK,Rosenbusch JP

更新日期：1993-01-29 00:00:00

abstract：:Atrial- and brain-type natriuretic peptides (ANP and BNP, respectively) have been shown to exert potent lipolytic action in adipocytes. A family of natriuretic peptide receptors (NPRs), NPR-1, NPR-2, and NPR-3, mediates their physiologic effects. NPR-1 and NPR-2 are receptor guanylyl cyclases, while NPR-3 lacks enzyma...

journal_title：Biochemical and biophysical research communications

authors： Nakatsuji H,Maeda N,Hibuse T,Hiuge A,Hirata A,Kuroda Y,Kishida K,Kihara S,Funahashi T,Shimomura I

更新日期：2010-01-29 00:00:00

abstract：:Kupffer cells, prepared 18 h after pretreatment of rats with a single dose of halothane, did carry TFA-adducts which were recognized on Western blots by a anti-TFA-antibody. Based on apparent molecular weight, the pattern of the major TFA-adducts within Kupffer cells was similar to that observed in hepatocytes. When k...

journal_title：Biochemical and biophysical research communications

authors： Christen U,Bürgin M,Gut J

更新日期：1991-02-28 00:00:00

abstract：:Extracellular DNA (eDNA) is a structural component of the polymeric matrix of biofilms from different species. Different mechanisms for DNA release have been proposed including lysis of cells, lysis of DNA-containing vesicles, and DNA secretion. Here, a genome-wide screen of 3985 non-lethal mutations was performed to ...

journal_title：Biochemical and biophysical research communications

authors： Sanchez-Torres V,Maeda T,Wood TK

更新日期：2010-10-15 00:00:00

abstract：:The Andean potato weevil, Premnotrypes vorax, an insect of the order Coleoptera, is a major cause of damage to potato crops in the Andean regions of South America. The insecticidal Cry proteins from Bacillus thuringiensis are useful biological pesticides, and some are toxic to Coleopteran insects. We overexpressed rec...

journal_title：Biochemical and biophysical research communications

authors： Gomez S,Mateus AC,Hernandez J,Zimmermann BH

更新日期：2000-12-20 00:00:00

abstract：:Metastatic hepatocellular carcinoma (HCC) remains a mostly incurable disease. The fact that the identity of the mechanisms that regulate metastasis in HCC is known hampers the development of anti-metastatic therapies. Currently, there is no effective treatment for HCC once it is progressed to metastatic stage. Therefo...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Liu ZG,Shi MQ,Yu HZ,Jiang XY,Yang AH,Fu XS,Xu Y,Yang S,Ni H,Shen SJ,Li WD

更新日期：2017-09-16 00:00:00

abstract：:The present study shows for the first time that in proopiomelanocortin cells of the rat intermediate pituitary gland ANF binds to two receptor forms, with apparent molecular weights of 150K and 70K. Scatchard plots revealed specific and high affinity non-interacting sites, with a KD value of about 3 nM and a density o...

journal_title：Biochemical and biophysical research communications

authors： Lutz-Bucher B,Boudjada T,Heisler S,Pelletier G,Koch B

更新日期：1988-08-30 00:00:00

abstract：:The thyroid hormone receptor alpha gene is alternatively spliced to give the alpha receptor and a variant which does not bind thyroid hormones. An additional alpha-like receptor (Rev-erbA alpha) is transcribed on the opposite strand and overlaps the unique variant sequence. The alpha receptor in rat brain reaches peak...

journal_title：Biochemical and biophysical research communications

authors： Jannini EA,Mitsuhashi T,Nikodem VM

更新日期：1992-04-30 00:00:00

abstract：:Protein L7 is associated with the large subunit of eukaryotic ribosomes that can act as a co-regulator of nuclear receptor-mediated transcription. In this study we show that L7 carries in addition to the known N-terminal nucleic acid-binding domain (NBD 1) a second one (NBD 2) which maps to the 50 C-terminal amino aci...

journal_title：Biochemical and biophysical research communications

authors： von Mikecz A,Neu E,Krawinkel U,Hemmerich P

更新日期：1999-05-19 00:00:00

abstract：:Cytochrome c3 (Mr 26,000) has been characterized in Desulfovibrio vulgaris (Hildenborough) and its properties compared with polyhemic cytochromes c isolated from the same organism and from D. desulfuricans (Norway). It can be described as an octaheme cytochrome c3 constituted of two identical subunits. Absorption spec...

journal_title：Biochemical and biophysical research communications

authors： Loutfi M,Guerlesquin F,Bianco P,Haladjian J,Bruschi M

更新日期：1989-03-15 00:00:00

abstract：:Cellobiose triggers the production of two endoglucanases, EglA and EglB, in Aspergillus nidulans. The cellulose responsive element (CeRE) cis-element that is essential for induction has been identified on the eglA promoter, but transcription factors that bind to CeRE have not yet been identified. CeRE contained a cons...

journal_title：Biochemical and biophysical research communications

authors： Yamakawa Y,Endo Y,Li N,Yoshizawa M,Aoyama M,Watanabe A,Kanamaru K,Kato M,Kobayashi T

更新日期：2013-02-22 00:00:00

abstract：:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30....

journal_title：Biochemical and biophysical research communications

authors： Yamaga N,Adachi K,Kohara H,Shimizu K

更新日期：1988-04-15 00:00:00