Halothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts.

abstract：:Recent findings identify the role of proliferation of pulmonary artery smooth muscle cells (PASMCs) in pulmonary vascular remodeling. Phosphoinositide 3 kinase (PI3K) and serine/threonine kinase (Akt) proteins are expressed in vascular smooth muscle cells. In addition, phosphatase and tensin homolog deleted on chromos...

journal_title：Biochemical and biophysical research communications

authors： Luo C,Yi B,Bai L,Xia Y,Wang G,Qian G,Feng H

更新日期：2010-07-02 00:00:00

abstract：:We have previously shown that C-CAM1 cell adhesion molecule can suppress the growth of prostate cancer cells in vivo. In this study, we determined the minimal domain of C-CAM1 that is required for its tumor-suppressive activity. DU145 prostate cancer cells were infected with recombinant adenoviruses containing various...

journal_title：Biochemical and biophysical research communications

authors： Estrera VT,Luo W,Phan D,Earley K,Hixson DC,Lin SH

更新日期：1999-10-05 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells and induces diff...

journal_title：Biochemical and biophysical research communications

authors： McNamara MJ,Schmitt JD,Wykle RL,Daniel LW

更新日期：1984-07-31 00:00:00

abstract：:Having ascertained using JC-1 as a probe that, in distinction with the controls, during capacitation boar sperm maintains high mitochondrial membrane potential (ΔΨ), to gain some insight into the role of mitochondria in capacitation, we monitored ΔΨ generation due to externally added metabolites either in hypotonicall...

journal_title：Biochemical and biophysical research communications

authors： Paventi G,Lessard C,Bailey JL,Passarella S

更新日期：2015-07-03 00:00:00

abstract：:Permeability alteration of microvascular endothelia is a factor in the plasma leakage produced by dengue virus (DV) infection, and beta3 integrin plays central roles in maintaining capillary integrity and regulating vascular permeability. In this study, interaction between beta3 integrin and DV serotype 2 (DV2) was in...

journal_title：Biochemical and biophysical research communications

authors： Zhang JL,Wang JL,Gao N,Chen ZT,Tian YP,An J

更新日期：2007-05-11 00:00:00

abstract：:The octaheme cytochrome c3 (Mr 26000) from Desulfovibrio desulfuricans Norway was studied using cyclic voltammetry at the pyrolytic graphite electrode. The kinetics of reduction of the octaheme cytochrome c3 (Mr 26000) from D. desulfuricans Norway by the Ni-Fe-Se hydrogenase purified from the same organism was investi...

journal_title：Biochemical and biophysical research communications

authors： Haladjian J,Bianco P,Guerlesquin F,Bruschi M

更新日期：1991-08-30 00:00:00

abstract：:Endothelial cells line the inside of all blood vessels forming a structurally and functionally highly heterogenous population of cells. Here we describe the application of the differential RNA display technique to the analysis of the heterogeneity of endothelial cells. Multiple fragment cDNAs from quiescent resting an...

journal_title：Biochemical and biophysical research communications

authors： Kozian DH,Augustin HG

更新日期：1995-04-26 00:00:00

abstract：:The hepatic microsomal monooxygenase system was studied in hypophysectomized male rats exposed for 24 or 48 h to PB and/or TPA, an activator of kinase C. TPA attenuated basal and PB-induced levels of P450, aniline hydroxylase (ANH), ethylmorphine demethylase (EDM) and cytochrome c reductase. Hence, PB may effect induc...

journal_title：Biochemical and biophysical research communications

authors： Steele DF,Virgo BB

更新日期：1988-06-16 00:00:00

abstract：:Cisplatin is one of the most widely used anticancer agents. Cisplatin-induced cytotoxicity results from its ability to form cisplatin-DNA adducts within the cellular genome which can inhibit the transcription of genes and the replication of DNA. Cisplatin-adducts are primarily removed by the nucleotide excision repair...

journal_title：Biochemical and biophysical research communications

authors： Yang WL,Cvijic ME,Ishii K,Chin KV

更新日期：1998-09-29 00:00:00

abstract：:Two genes that hybridize to the cDNA for alcohol-inducible cytochrome P-450 form 3a (P-450ALC) have been isolated from a rabbit genomic library and characterized by restriction mapping, hybridization, and partial sequence analysis. The genes show extensive sequence similarity as judged by hybridization at high stringe...

journal_title：Biochemical and biophysical research communications

authors： Khani SC,Porter TD,Coon MJ

更新日期：1988-01-15 00:00:00

abstract：:The radiation inactivation method was applied to brush border membrane vesicles from rat kidney, in order to estimate the molecular size of the Na+-H+ antiporter. Sodium influx (1mM) driven by an acid intravesicular pH was unaffected by the high osmolarity of the cryoprotective solution. Initial rate of influx was est...

journal_title：Biochemical and biophysical research communications

authors： Béliveau R,Demeule M,Potier M

更新日期：1988-04-15 00:00:00

abstract：:Parathyroid hormone secretion is negatively regulated by calcium. We utilized calcium channel agents: +202-791, a calcium channel agonist and -202-791, a calcium channel antagonist, to evaluate the role of calcium channels in PTH secretion. +202-791 inhibited PTH release from bovine parathyroid cells and the antagonis...

journal_title：Biochemical and biophysical research communications

authors： Fitzpatrick LA,Brandi ML,Aurbach GD

更新日期：1986-07-31 00:00:00

abstract：:More than 80% of tumors that occur in the brain are malignant gliomas. The prognosis of glioma patients is still poor, which makes glioma an urgent subject of cancer research. Previous evidence and our present data show that PCBP2 is over-expressed in human glioma tissues and predicts poor outcome. However, the mechan...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Hao B,Liu Y,Dai D,Han G,Li Y,Wu X,Zhou X,Yue Z,Wang L,Cao Y,Liu J

更新日期：2014-03-28 00:00:00

abstract：:The gene encoding the human puromycin-sensitive aminopeptidase (PSA) has been cloned and characterized. The human PSA gene is composed of 23 exons and 22 introns and spans approximately 40 kb of chromosome 17 at the interval 17q12-21. An analysis of the 5' end of the human PSA transcript reveals that the translational...

journal_title：Biochemical and biophysical research communications

authors： Thompson MW,Tobler A,Fontana A,Hersh LB

更新日期：1999-05-10 00:00:00

abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

journal_title：Biochemical and biophysical research communications

authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

更新日期：2019-04-30 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and potent antibody-dependent cell-mediated cytotoxicity (ADCC) are recommended. Previously, a panel of functional epitopes that can elicit ADCC ef...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Liu M,Ding N,Li Y,Shao J,Zhu M,Xie Z,Sun K

更新日期：2018-09-10 00:00:00

abstract：:TorD is the private chaperone of TorA, a periplasmic respiratory molybdoenzyme of Escherichia coli. In this study, it is demonstrated that TorD is required to maintain the integrity of the twin-arginine signal sequence of the cytoplasmic TorA precursors. In the absence of TorD, 35 out of the 39 amino acid residues of ...

journal_title：Biochemical and biophysical research communications

authors： Genest O,Seduk F,Ilbert M,Méjean V,Iobbi-Nivol C

更新日期：2006-01-20 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00

abstract：:The human dopamine D4 receptor gene (DRD4) is an important candidate gene for schizophrenia. We identified a novel -521C>T polymorphism in the 5'-promoter region of DRD4. A transient expression method revealed that the T allele of this polymorphism reduces the transcriptional efficiency by 40% compared with the C alle...

journal_title：Biochemical and biophysical research communications

authors： Okuyama Y,Ishiguro H,Toru M,Arinami T

更新日期：1999-05-10 00:00:00

abstract：:The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of the cysteine 121 to trpyptophane (C121W) would cause a lack of modulato...

journal_title：Biochemical and biophysical research communications

authors： Moran O,Conti F

更新日期：2001-03-23 00:00:00

abstract：:The complex of immobilized human plasminogen (iHPlg) and streptokinase (SK) has a lower catalytic activity in hydrolysis of plasmin-specific substrate S-2251 with a kcat/Km of 0.005 microM-1 x s-1, compared to 0.031 microM-1 x s-1 of immobilized human plasmin (iHPlm) and 0.078 microM-1 x s-1 of HPlm. The SK in the com...

journal_title：Biochemical and biophysical research communications

authors： Shi GY,Chang BI,Wu DH,Wu HL

更新日期：1993-08-31 00:00:00

abstract：:These studies sought to test the hypothesis that magnesium inhibits extracellular calcium entry, thereby inhibiting intracellular calcium release and cytosolic calcium oscillations in myometrial smooth muscle. In vitro contraction studies were performed using oxytocin and other uterotonic agonists with and without the...

journal_title：Biochemical and biophysical research communications

authors： Phillippe M

更新日期：1998-11-18 00:00:00

abstract：:The ability of two 15-ketosubstituted sterols, 5alpha-cholest-8(14)-en-3beta-ol-15-one and 3beta-(2-hydroxyethoxy)-5alpha-cholest-8(14)-en-15-one, to alter the mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase, low density lipoprotein receptor, and oxysterol binding protein was studied and compared with the effe...

journal_title：Biochemical and biophysical research communications

authors： Kisseleva AF,Goryunova LE,Planells R,Lafont H,Alquier C

更新日期：1999-06-16 00:00:00

abstract：:As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoc...

journal_title：Biochemical and biophysical research communications

authors： Thorlacius H,Raud J,Rosengren-Beezley S,Forrest MJ,Hedqvist P,Lindbom L

更新日期：1994-09-15 00:00:00

abstract：:The PAX3 transcription factor is the key regulator of melanocyte development during embryogenesis and is also frequently found in melanoma cells. While PAX3 is known to regulate melanocyte differentiation, survival, proliferation and migration during development, it is not clear if its function is maintained in adult ...

journal_title：Biochemical and biophysical research communications

authors： Medic S,Rizos H,Ziman M

更新日期：2011-08-12 00:00:00

abstract：:Polymerization of actin induced by activation of platelets was investigated using deoxyribonuclease I inhibition assay. When platelets were activated with ADP or 5-hydroxytryptamine, actin was polymerized quickly followed by rapid depolymerization to the initial level. Reactivation with the same agonist, however, did ...

journal_title：Biochemical and biophysical research communications

authors： Imada T,Kikuchi T,Shimada H,Inada Y,Saito Y

更新日期：1984-05-16 00:00:00

abstract：:Leber hereditary optic neuropathy (LHON) was the first disease to be linked to the presence of a mitochondrial DNA (mtDNA) mutation. Nowadays over 95% of LHON cases are known to be caused by one of three primary mutations (m.11778G>A, m.14484T>C, and m.3460G>A). Reports for other (rare) primary mutations in LHON patie...

journal_title：Biochemical and biophysical research communications

authors： Zhang AM,Zou Y,Guo X,Jia X,Zhang Q,Yao YG

更新日期：2009-08-21 00:00:00

abstract：:The transmembrane chemokine CX3CL1 is expressed on the endothelial surface and promotes leukocyte adhesion and transmigration by receptor interaction via its extracellular chemokine domain. Since little is known about its intracellular C-terminus, we examined the consequences of C-terminal truncation on cellular distr...

journal_title：Biochemical and biophysical research communications

authors： Andrzejewski MG,Koelsch A,Kogel T,Dreymueller D,Schwarz N,Ludwig A

更新日期：2010-04-30 00:00:00

abstract：:Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increas...

journal_title：Biochemical and biophysical research communications

authors： Nakadate Y,Kodera Y,Kitamura Y,Tachibana T,Tamura T,Koizumi F

更新日期：2013-11-29 00:00:00