Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene.

abstract：:Retinoids induce marked growth inhibition and neuritic differentiation in human neuroblastoma cells. Expression patterns of nuclear retinoic acid receptors (RAR) in embryonic and adult tissues suggests that RAR subtypes alpha, beta and gamma have tissue-specific functions. We have transfected a human neuroblastoma tum...

journal_title：Biochemical and biophysical research communications

authors： Cheung B,Hocker JE,Smith SA,Reichert U,Norris MD,Haber M,Stewart BW,Marshall GM

更新日期：1996-12-04 00:00:00

abstract：:When small amounts (1 microgram) of lipopolysaccharide (LPS) purified from Salmonella minnesota (SM) wild, SM R60 and SM R345 were intravenously injected into mice 7 days after heat-killed Propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 ...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi Y,Sakagami Y,Kuboi H,Kobayashi K,Yano I

更新日期：1988-09-30 00:00:00

abstract：:Recent studies have reported elevated expression of miR-181a in patients with non-alcoholic fatty liver disease (NAFLD), suggesting that it may play an important role in liver lipid metabolism and insulin resistance. We aimed to investigate the effect of miR-181a in lipid metabolism and find new treatments for NAFLD. ...

journal_title：Biochemical and biophysical research communications

authors： Huang R,Duan X,Liu X,Cao H,Wang Y,Fan J,Wang B

更新日期：2019-01-22 00:00:00

abstract：:S-nitrosothiols (SNOs) are endogenous signaling molecules with a broad spectrum of beneficial airway effects. SNOs are normally present in the airway, but levels tend to be low in cystic fibrosis (CF) patients. We and others have demonstrated that S-nitrosoglutathione (GSNO) increases the expression, maturation, and f...

journal_title：Biochemical and biophysical research communications

authors： Zaman K,Bennett D,Fraser-Butler M,Greenberg Z,Getsy P,Sattar A,Smith L,Corey D,Sun F,Hunt J,Lewis SJ,Gaston B

更新日期：2014-01-24 00:00:00

abstract：:A soluble factor, extracted from neutrophils and P388D1 cells, stimulated a transient rise in cytosolic free Ca2+ and a small increase in the permeability to Mn2+ in fura2-loaded neutrophils. These effects were not prevented by blockade of formylated peptide receptors by t-boc-met-leu-phe. The rise in cytosolic free C...

journal_title：Biochemical and biophysical research communications

authors： Davies EV,Hallett MB

更新日期：1995-01-05 00:00:00

abstract：:Norepinephrine (NE) modulates brain functions depending on both the internal and external environment. While the neuromodulatory actions of NE have been well characterized, the response and involvement of cortical astrocytes to physiological noradrenergic systems remain largely unknown, especially at the molecular lev...

journal_title：Biochemical and biophysical research communications

authors： Nuriya M,Morita A,Shinotsuka T,Yamada T,Yasui M

更新日期：2018-10-12 00:00:00

abstract：:Missense mutations in the enzyme, glycine N-methyltransferase (GNMT) have been shown to be one cause of persistent isolated hypermethioninaemia in humans. These mutations were first identified by metabolite analysis and were shown to be L49P, N140S, and H176N by gene sequencing. Here we report the kinetic and conforma...

journal_title：Biochemical and biophysical research communications

authors： Luka Z,Wagner C

更新日期：2003-12-26 00:00:00

abstract：:Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat ...

journal_title：Biochemical and biophysical research communications

authors： Muñoz JP,Collao A,Chiong M,Maldonado C,Adasme T,Carrasco L,Ocaranza P,Bravo R,Gonzalez L,Díaz-Araya G,Hidalgo C,Lavandero S

更新日期：2009-10-09 00:00:00

abstract：:Botulinum neurotoxin (NT) serotype A isolated from cells from young cultures (approximately 8 h) of Clostridium botulinum type A is a approximately 150 kDa single chain protein. Supernatant from older cultures (96 h) yields approximately 150 kDa dichain NT composed approximately 50 and approximately 100 kDa subunits, ...

journal_title：Biochemical and biophysical research communications

authors： Dekleva ML,DasGupta BR

更新日期：1989-07-31 00:00:00

abstract：:Angiogenesis is a fundamental process by which new blood vessels are formed. The angiogenesis process is induced by several growth factors. Among them angiogenin is the most potent blood vessel inducer known. In this paper, we have investigated the effect of green tea polyphenols, mainly the catechins, on an angiogeni...

journal_title：Biochemical and biophysical research communications

authors： Maiti TK,Chatterjee J,Dasgupta S

更新日期：2003-08-15 00:00:00

abstract：:Topical application of hexadecane has been shown to induce hyperproliferation and hyperkeratosis in rodent skin. The application of hexadecane to epidermis from the backs of piglets less than 1 week old resulted in a rapid biphasic-rise in the level of ornithine decarboxylase (ODC) activity. The second phase of the el...

journal_title：Biochemical and biophysical research communications

authors： Owusu S,Cunliffe WJ,Wood EJ

更新日期：1989-06-30 00:00:00

abstract：:Transfer of the gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis in scurvy-prone animals, into medaka (Oryzias latipes) was successfully done. The expression plasmid pSVL-GLO, carrying rat liver L-gulono-gamma-lactone oxidase cDNA, was microinjected into the cytoplasm of fert...

journal_title：Biochemical and biophysical research communications

authors： Toyohara H,Nakata T,Touhata K,Hashimoto H,Kinoshita M,Sakaguchi M,Nishikimi M,Yagi K,Wakamatsu Y,Ozato K

更新日期：1996-06-25 00:00:00

abstract：:Total kininogen in plasma of Freund's adjuvant treated rats increased 20-fold 7 days following the injection. Analysis of the kininogens demonstrated that increases in T-kininogen was the major reason for the rise in kininogen. High molecular weight and low molecular weight kininogens showed little or no change. The i...

journal_title：Biochemical and biophysical research communications

authors： Barlas A,Okamoto H,Greenbaum LM

更新日期：1985-05-31 00:00:00

abstract：BACKGROUND:Plasma levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease and are influenced by both heredity and dietary habits. The Niemann-Pick C1 like 1 (NPC1L1) protein mediates efficient dietary cholesterol absorption and contributes to variations in human LDL-C le...

journal_title：Biochemical and biophysical research communications

authors： Yuan Q,Fu Z,Wei J,Li PS,Miao HH,Qu YX,Xu J,Qin J,Li BL,Song BL,Ma Y

更新日期：2016-10-28 00:00:00

abstract：:Human embryonic stem cells (hESC) are pluripotent, and can be directed to differentiate into different cell types for therapeutic applications. To expand hESCs, it is desirable to maintain hESC growth without differentiation. As hESC colonies grow, differentiated cells are often found at the periphery of the colonies,...

journal_title：Biochemical and biophysical research communications

authors： Lam H,Patel S,Wong J,Chu J,Lau A,Li S

更新日期：2008-08-08 00:00:00

abstract：OBJECT:The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular disease...

journal_title：Biochemical and biophysical research communications

authors： Ikedo T,Minami M,Kataoka H,Hayashi K,Nagata M,Fujikawa R,Yamazaki F,Setou M,Yokode M,Miyamoto S

更新日期：2018-01-01 00:00:00

abstract：:The detergent (Triton X-100, 4°C)-resistant membrane (DRM)-associated membrane proteins stomatin, sorcin, and synexin (anexin VII) exposed on the cytoplasmic side of membrane were investigated for their lateral distribution in relation to induced ganglioside(M1) (GM1) raft patches in flat (discocytic) and curved (echi...

journal_title：Biochemical and biophysical research communications

authors： Mrówczyńska L,Salzer U,Perutková S,Iglič A,Hägerstrand H

更新日期：2010-10-22 00:00:00

abstract：:As vectors, adenoviruses (Ads) have many attractive advantages for in vivo gene therapy. However, Ads do not usually integrate into the host genome and gene expression is, thus, transient. Adeno-associated virus (AAV) integrates into a specific locus (AAVS1) on the human host's chromosome 19, while conventional recomb...

journal_title：Biochemical and biophysical research communications

authors： Ueno T,Matsumura H,Tanaka K,Iwasaki T,Ueno M,Fujinaga K,Asada K,Kato I

更新日期：2000-07-05 00:00:00

abstract：:Rabbit brain synaptosomes bind the 1,4-dihydropyridine derivative (+)[3H]-PN 200-110 with an equilibrium dissociation constant of 0.04 nM and a maximal binding capacity of 400 fmol/mg of protein. Using polyclonal antibodies raised against the different components of the skeletal muscle 1,4-dihydropyridine receptor, we...

journal_title：Biochemical and biophysical research communications

authors： Schmid A,Barhanin J,Mourre C,Coppola T,Borsotto M,Lazdunski M

更新日期：1986-09-30 00:00:00

abstract：:Glycogen phosphorylase in PC12 cells exists in two forms analogous to those found in brain and muscle. The active phosphorylated form of the enzyme, phosphorylase-a, represents about 20-30% of total glycogen phosphorylase in these cells. Incubation of PC12 cells with 100 ng 7S nerve growth factor/ml increased phosphor...

journal_title：Biochemical and biophysical research communications

authors： Davis LH,Kauffman FC

更新日期：1986-07-31 00:00:00

abstract：:We have constructed a hybrid multicomponent dioxygenase gene cluster in which the bphA1 gene, coding for ISP alpha subunit of biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707, has been replaced by the bedC1 gene encoding the corresponding subunit of benzene dioxygenase from P. putida ML2. Escherichia coli...

journal_title：Biochemical and biophysical research communications

authors： Tan HM,Cheong CM

更新日期：1994-10-28 00:00:00

abstract：:The objective was to investigate whether a graphene coating could improve the surface bioactivity of a cobalt-chromium-molybdenum-based alloy (CoCrMo). Graphene was produced by chemical vapor deposition and transferred to the surface of the CoCrMo alloy using an improved wet transfer approach. The morphology of the sa...

journal_title：Biochemical and biophysical research communications

authors： Zhang Q,Li K,Yan J,Wang Z,Wu Q,Bi L,Yang M,Han Y

更新日期：2018-03-18 00:00:00

abstract：:Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as meas...

journal_title：Biochemical and biophysical research communications

authors： Tseng A Jr,Brooks M,Cadman E

更新日期：1986-07-31 00:00:00

abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

journal_title：Biochemical and biophysical research communications

authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

更新日期：2018-09-10 00:00:00

abstract：:Bacterial endotoxins or lipopolysaccharides (LPS), cell wall components of gram negative bacteria, are involved in septic shock. While the carbohydrate structure of LPS have been studied in the past, little is known about the macromolecular structure and formation of LPS fragments in blood. It is believed that amphiph...

journal_title：Biochemical and biophysical research communications

authors： Aurell CA,Wistrom AO

更新日期：1998-12-09 00:00:00

abstract：:Sepiapterin reductase (SPR) is an enzyme that acts in the third and final step of tetrahydrobiopterin (BH4) biosynthesis. The human Spr gene locates within the region of 2.5MB mapped to PARK3, an autosomal dominant form of familial Parkinson's diseases. In order to explore the role of SPR in the metabolism of BH4, we ...

journal_title：Biochemical and biophysical research communications

authors： Takazawa C,Fujimoto K,Homma D,Sumi-Ichinose C,Nomura T,Ichinose H,Katoh S

更新日期：2008-03-21 00:00:00

abstract：:P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to various stress insults that threaten DNA integrity. P53 levels and activities are kept under tight regulation involving a complex network of activators and inhibitors, which determine the type and extent of p53 growth inhibitory s...

journal_title：Biochemical and biophysical research communications

authors： Levav-Cohen Y,Goldberg Z,Zuckerman V,Grossman T,Haupt S,Haupt Y

更新日期：2005-06-10 00:00:00

abstract：:Oncogenic ras upregulates the expression of VEGF through the activation of the transcriptional enhancer hypoxia inducible factor-1alpha (HIF-1alpha) by a still poorly understood mechanism. Here, we demonstrate that both the Raf/MEK/MAPK and the PI3 kinase/Akt signaling pathways potently and additively stimulate the ex...

journal_title：Biochemical and biophysical research communications

authors： Sodhi A,Montaner S,Miyazaki H,Gutkind JS

更新日期：2001-09-14 00:00:00

abstract：:In epithelial cells progression through the G1 phase of the cell cycle and preparing the cell for the S phase is regulated by cyclin D1-cdk4. Cells that express the retinoblastoma protein (pRb) are dependent on cyclin D1-cdk4 activity for their proliferation while cells that do not express pRb are not. Overexpression ...

journal_title：Biochemical and biophysical research communications

authors： Kent LL,Hull-Campbell NE,Lau T,Wu JC,Thompson SA,Nori M

更新日期：1999-07-14 00:00:00

abstract：:Lipopolysaccharide (LPS) stimulates macrophages by activating NF-kappaB, which contributes to the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. 1,5-Anhydro-D-fructose (1,5-AF), a monosaccharide formed from starch and glycogen, exhibits anti-oxidant activity and enhances insulin secretion. This s...

journal_title：Biochemical and biophysical research communications

authors： Meng X,Kawahara K,Nawa Y,Miura N,Shrestha B,Tancharoen S,Sameshima H,Hashiguchi T,Maruyama I

更新日期：2009-03-06 00:00:00