Retinoic acid receptors beta and gamma distinguish retinoid signals for growth inhibition and neuritogenesis in human neuroblastoma cells.

abstract：:Cytokine induced pancreatic beta-cell destruction seen in Type 1 diabetes and islet graft rejection involves multiple intracellular signaling pathways that directly or indirectly lead to inflammatory damage or programmed cell death. IL-1beta has been shown to stimulate the 12-lipoxygenase pathway product 12-HETE, in R...

journal_title：Biochemical and biophysical research communications

authors： Bleich D,Chen S,Wen Y,Nadler JL

更新日期：1997-01-13 00:00:00

abstract：:Eosinophil cationic protein (ECP) is a toxin secreted by activated human eosinophils. The properties of mature ECP have been well studied but those of the signal peptide of ECP (ECPsp) are not clear. In this study, several chimeric proteins containing N-terminal fusion of ECPsp were generated, and introduced into Esch...

journal_title：Biochemical and biophysical research communications

authors： Wu CM,Chang MD

更新日期：2004-09-17 00:00:00

abstract：:Previously, we have reported that two clustered cat genes from Acenitobacter lwoffi K24 had different arrangements, catB1C1A1 and catB2A2C2 (Kim, S.I., S.-H. Leem, J.-S. Choi, Y.H. Chung, S. Kim, Y.-M. Park, Y.K. Park, Y.N. Lee, and K.-S. Ha. 1997, J. Bacteriol. 179, 5226-5231). By further analysis of the organization...

journal_title：Biochemical and biophysical research communications

authors： Kim SI,Leem SH,Choi JS,Ha KS

更新日期：1998-02-04 00:00:00

abstract：:The ouabain-resistant and ouabain-sensitive alpha-subunit cRNAs in various molar ratios were injected into Xenopus oocytes together with cRNA for the beta-subunit. The ouabain-resistant ATPase activity, as well as ouabain-resistant Rb+ uptake, of the injected oocytes increased linearly with increasing the amount of cR...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Kawamura M

更新日期：2001-02-09 00:00:00

abstract：:Intestinal epithelial cells (IECs) must be tolerant of the large number of commensal bacteria inhabiting the intestinal tract to avoid excessive inflammatory reactions. Toll-interacting protein (Tollip), a negative regulator of Toll-like receptor signaling, is known to be expressed at high levels in IECs, and to there...

journal_title：Biochemical and biophysical research communications

authors： Sugi Y,Takahashi K,Nakano K,Hosono A,Kaminogawa S

更新日期：2011-09-09 00:00:00

abstract：:The contribution of four transport pathways to Li+ influx in human, chicken and eel erythrocytes was studied. All pathways were measured simultaneously in each kind of blood sample to avoid possible temporal variations in transport parameters. We found that: 1) Li+ influx via Na(+)-K+ pump increased 2-3 fold in the or...

journal_title：Biochemical and biophysical research communications

authors： Romano L,Battaglia M,Cordì R,Rinaldi C,Leucci S,Amato A

更新日期：1995-05-05 00:00:00

abstract：:The molecular mechanisms by which chronic hypoxia, whether constant (CCH) or intermittent (CIH), alters the heart rhythm are still under debate. Expression level, control, maturational profile and intercoordination of 54 genes encoding heart rhythm determinants (HRDs) were analyzed in 36 mice subjected for 1, 2 or 4 w...

journal_title：Biochemical and biophysical research communications

authors： Iacobas DA,Iacobas S,Haddad GG

更新日期：2010-01-22 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) decreases the growth of certain cancer cells. In the present study, we found that six different human pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-2, HPAF-II, MIA PaCa-2, and PANC-1) expressed PPAR-gamma m-RNA and synthesized the protein. The endogen...

journal_title：Biochemical and biophysical research communications

authors： Eibl G,Wente MN,Reber HA,Hines OJ

更新日期：2001-09-21 00:00:00

abstract：:Methylation-specific PCR (MSP) is frequently used to distinguish methylated alleles in the genome. Sequences that have been incompletely converted during bisulfite treatment are frequently co-amplified during MSP. For accurate MSP, it is important to detect methylated sequences in a background of unconverted DNA with ...

journal_title：Biochemical and biophysical research communications

authors： Sasaki M,Anast J,Bassett W,Kawakami T,Sakuragi N,Dahiya R

更新日期：2003-09-19 00:00:00

abstract：:The identity of cDNA encoding beta 1,4 galactosyltransferase (EC 2.4.1.38) has been controversial, since two independent and unrelated cDNAs have been cloned (GTcDNA-1 and -2), both of which are thought to encode beta 1,4 galactosyltransferase. We have resolved this issue by examining the expression of the correspondi...

journal_title：Biochemical and biophysical research communications

authors： Lopez LC,Shur BD

更新日期：1988-11-15 00:00:00

abstract：:Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a site near the amino-terminus, and quantitatively releases the larg...

journal_title：Biochemical and biophysical research communications

authors： Eide B,Gierschik P,Milligan G,Mullaney I,Unson C,Goldsmith P,Spiegel A

更新日期：1987-11-13 00:00:00

abstract：:SHPS-1 is a receptor-type transmembrane glycoprotein, which contains four tyrosine residues in its cytoplasmic region, and the phosphorylation of these tyrosine residues serves the binding sites for SHP-2 protein-tyrosine phosphatase. Its extracellular region interacts with another membrane protein, CD47, thereby cons...

journal_title：Biochemical and biophysical research communications

authors： Sato R,Ohnishi H,Kobayashi H,Kiuchi D,Hayashi A,Kaneko Y,Honma N,Okazawa H,Hirata Y,Matozaki T

更新日期：2003-09-26 00:00:00

abstract：:There is a close linear correlation between the log partition coefficient (Pa) of a series of 2'-deoxyriboside (dR), 2',3'-didehydro-3'-dideoxyriboside (ddeR), 2',3'-dideoxyriboside (ddR), 3'-fluoro-2',3'-dideoxyriboside (FddR) and 3'-azido-2',3'-dideoxyriboside (AzddR) derivatives of uracil, cytosine, thymine, guanin...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Cools M,De Clercq E

更新日期：1989-01-31 00:00:00

abstract：:We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-defici...

journal_title：Biochemical and biophysical research communications

authors： Yan X,Kuipers F,Havekes LM,Havinga R,Dontje B,Poelstra K,Scherphof GL,Kamps JA

更新日期：2005-03-04 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. ...

journal_title：Biochemical and biophysical research communications

authors： Khan MH,Hart MJ,Rea SL

更新日期：2012-08-24 00:00:00

abstract：:Sphingosine-1-phosphate (S1P)-induced migration and proliferation of endothelial cells are critical for angiogenesis. C2H2-zinc finger (ZNF) proteins usually play an essential role in altering gene expression and regulating the angiogenesis. The aim of this study is to investigate whether a novel human C2H2-zinc finge...

journal_title：Biochemical and biophysical research communications

authors： Sun HY,Wei SP,Xu RC,Xu PX,Zhang WC

更新日期：2010-05-07 00:00:00

abstract：:The hepatocyte growth factor is closely related to liver regeneration. And the c-met protooncogene is reported to encode a hepatocyte growth factor receptor. Little is known, however, about how the c-met gene is activated during liver regeneration. In this study, we demonstrated that expression of the c-met gene/hepat...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Hayashi N,Horimoto M,Sasaki Y,Tanaka Y,Kaneko A,Fusamoto H,Kamada T

更新日期：1993-02-15 00:00:00

abstract：:The correlation between the increase of [Ca2+]i and the activation of hydrolysis of phosphoinositide-4,5-bisphosphate and formation of inositol(1,4,5)trisphosphate in neutrophils treated with Fc receptor-binding agonists is still under discussion. In this communication evidence is presented supporting the conclusion t...

journal_title：Biochemical and biophysical research communications

authors： Della Bianca V,Grzeskowiak M,Dusi S,Rossi F

更新日期：1993-11-15 00:00:00

abstract：:The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm...

journal_title：Biochemical and biophysical research communications

authors： Neumivakin LV,Solovjev VP,Sokhansanj A,Tilba VA,Moseiko NA,Shachbasian RV,Piruzian ES

更新日期：1995-12-26 00:00:00

abstract：:Hepatocyte growth factor, which is now known to be the same protein as scatter factor, induced oligonucleosomal fragmentation of nuclear DNA of Sarcoma 180 cells and increased the activity of caspase-3, a key component in control of the apoptotic cell death pathway to about 2.6 times that in control cells on 48 hr inc...

journal_title：Biochemical and biophysical research communications

authors： Arakaki N,Kazi JA,Kazihara T,Ohnishi T,Daikuhara Y

更新日期：1998-04-07 00:00:00

abstract：:In our efforts to identify immunoreactive antigens in ovarian cancer, we used the method of immunoscreening of an ovarian carcinoma cDNA expression library with ascites fluid from ovarian cancer patients. Among many positive clones, one was found to contain partial sequence of a novel gene. By searching expressed sequ...

journal_title：Biochemical and biophysical research communications

authors： Luo LY,Soosaipillai A,Diamandis EP

更新日期：2001-01-12 00:00:00

abstract：:Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxic conditions is the fundamental cause of pathological neovascularization in retinal ischemic diseases and cancers. Recent studies have shown that histone lysine demethylases (KDMs) play a key role in the amplification of HIF signali...

journal_title：Biochemical and biophysical research communications

authors： Vavilala DT,Ponnaluri VK,Vadlapatla RK,Pal D,Mitra AK,Mukherji M

更新日期：2012-06-08 00:00:00

abstract：:The cell number as well as the hexokinase and glucokinase activity of liver parenchymal and nonparenchymal cells were studied in methapyrilene treated rats. The number of nonparenchymal cells was doubled after treatment with methapyrilene for two weeks while that of hepatocytes remained constant. The hexokinase activi...

journal_title：Biochemical and biophysical research communications

authors： Fischer W,Wagle SR,Katz NR

更新日期：1983-09-30 00:00:00

abstract：:In continuation of our recent observations indicating the presence of a lone calcineurin-dependent response element (CDRE) in the -3730bp upstream region of copper-induced metallothionein (CuMT) gene of Neurospora [K.S. Kumar, S. Dayananda, C. Subramanyam, Copper alone, but not oxidative stress, induces copper-metallo...

journal_title：Biochemical and biophysical research communications

authors： Kumar KS,Ravi Kumar B,Siddavattam D,Subramanyam C

更新日期：2006-07-07 00:00:00

abstract：BACKGROUND:Recently, it has been reported that hypoxia highly enhances expression of peptidylarginine deiminase (PAD) 4 and production of citrullinated proteins in some tumor cells. However, little is known about malignant gliomas on this issue. Therefore, we here investigated whether expression of PADs was induced by ...

journal_title：Biochemical and biophysical research communications

authors： Sase T,Arito M,Onodera H,Omoteyama K,Kurokawa MS,Kagami Y,Ishigami A,Tanaka Y,Kato T

更新日期：2017-01-01 00:00:00

abstract：:To determine whether the two domains of hepatitis C virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins--the NS3H protein, containing only the helicase domain, the full-leng...

journal_title：Biochemical and biophysical research communications

authors： Kuang WF,Lin YC,Jean F,Huang YW,Tai CL,Chen DS,Chen PJ,Hwang LH

更新日期：2004-04-23 00:00:00

abstract：:A predictive scar animal model is needed in order to study the mechanism and assess the therapies before its use in humans. However, due to the differences in wound healing patterns and regeneration ability, none of the existing models can fully simulate the characteristics of human scar. The aim of this study was to ...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Li S,Li K,Jiang X,Zhang J,Liu H

更新日期：2020-06-04 00:00:00

abstract：:Skeletal tissue contains a network of nerve fibers expressing several neuropeptides, including vasoactive intestinal peptide (VIP) and the related peptide pituitary adenylate cyclase activating peptide (PACAP). These peptides have been demonstrated to regulate osteoclast formation and osteoclast activity. Using atomic...

journal_title：Biochemical and biophysical research communications

authors： Ransjö M,Lie A,Mukohyama H,Lundberg P,Lerner UH

更新日期：2000-08-02 00:00:00

abstract：:Altered architecture, composition and quality of the extracellular matrix (ECM) are pathological hallmarks of several inflammatory and fibro-proliferative pathological processes such as osteoarthritis (OA), rheumatoid arthritis (RA), fibrosis and cancer. One of the most important components of the ECM is fibronectin. ...

journal_title：Biochemical and biophysical research communications

authors： Bager CL,Gudmann N,Willumsen N,Leeming DJ,Karsdal MA,Bay-Jensen AC,Høgdall E,Balslev I,He Y

更新日期：2016-09-16 00:00:00