The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.

Abstract:

:We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-deficient mice. ApoE deficiency did not affect hepatic uptake of negatively charged liposomes but lowered that of neutral liposomes >5-fold. Hepatocyte uptake of neutral liposomes was reduced >20-fold in apoE-deficient mice; that of negatively charged liposomes remained unchanged. We conclude that uptake of neutral liposomes by hepatocytes is nearly exclusively apoE-mediated.

authors

Yan X,Kuipers F,Havekes LM,Havinga R,Dontje B,Poelstra K,Scherphof GL,Kamps JA

doi

10.1016/j.bbrc.2004.12.137

subject

Has Abstract

pub_date

2005-03-04 00:00:00

pages

57-62

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02954-7

journal_volume

328

pub_type

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