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GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.

Abstract：

:Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a site near the amino-terminus, and quantitatively releases the large fragment (comprising all but an amino-terminal 2 kDa piece) from the membrane. Our results indicate that alpha subunits are essentially cytoplasmic proteins tethered to the inner surface of the membrane via an amino terminal stalk.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Eide B,Gierschik P,Milligan G,Mullaney I,Unson C,Goldsmith P,Spiegel A

doi

10.1016/s0006-291x(87)80287-5

subject

Has Abstract

pub_date

1987-11-13 00:00:00

pages

1398-405

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80287-5

journal_volume

148

pub_type

杂志文章

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