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2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.

Abstract：

:The effects of anadamide, 2-arachidonoylglycerol and related compounds on the specific binding of a radiolabeled cannabinoid receptor ligand,[3H]CP55940, to synaptosomal membranes were examined. Anandamide, an endogenous cannabinoid receptor ligand, reduced the specific binding of [3H]CP55940 to synaptosomal membranes in a dose-dependent manner: the Ki value was 89 nM. 2-Arachidonoylglycerol was also shown to bind appreciably to the cannabinoid receptor in competitive inhibition experiments. The apparent binding affinity was markedly increased when the binding assay was carried out in the presence of the esterase inhibitor DFP or at 0 degrees C. Free arachidonic acid and N-palmitoylethanolamine were almost inactive in terms of binding to the cannabinoid receptor in synaptosomal membranes. 2-Arachidonoylglycerol may be an endogenous cannabinoid receptor ligand in the brain.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sugiura T,Kondo S,Sukagawa A,Nakane S,Shinoda A,Itoh K,Yamashita A,Waku K

doi

10.1006/bbrc.1995.2437

subject

Has Abstract

pub_date

1995-10-04 00:00:00

pages

89-97

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X85724370

journal_volume

215

pub_type

杂志文章

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