The structure of SecB/OmpA as visualized by electron microscopy: The mature region of the precursor protein binds asymmetrically to SecB.

abstract：:Defects in neurogenesis and neuronal differentiation in the fetal brain of Down syndrome (DS) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of Alzheimer's disease, those being the most common phenotype in DS. I...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Kadota M,Nishigaki R,Kazuki Y,Shirayoshi Y,Rogers MS,Gojobori T,Ikeo K,Oshimura M

更新日期：2004-02-06 00:00:00

abstract：:Mutations in vacuolar protein sorting 13A (VPS13A) gene are responsible for chorea-acanthocytosis (ChAc). We previously determined the full-length sequence and exon-intron structure of mouse VPS13A and generated a ChAc model mouse by using the gene targeting technique. In the process, we found diverse 5' and 3' transc...

journal_title：Biochemical and biophysical research communications

authors： Mizuno E,Nakamura M,Agemura A,Kusumoto A,Ichiba M,Kurano Y,Muroya S,Sano A

更新日期：2007-02-23 00:00:00

abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

journal_title：Biochemical and biophysical research communications

authors： Mulder E,Vrij AA,Brinkmann AO

更新日期：1983-08-12 00:00:00

abstract：:AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The...

journal_title：Biochemical and biophysical research communications

authors： Folkers K,Langsjoen P,Nara Y,Muratsu K,Komorowski J,Richardson PC,Smith TH

更新日期：1988-06-16 00:00:00

abstract：:Ultrastructural data are presented on time-course changes in isolated rat hepatocyte suspensions exposed either to 1.2 or 1.8 mM CCl4 for up to 1 h. The subcellular changes at the lower concentration, but not the higher, are shown to closely parallel those reported to occur in rat hepatocytes following ingestion of CC...

journal_title：Biochemical and biophysical research communications

authors： Tyson CA,Story DL,Stephens RJ

更新日期：1983-07-29 00:00:00

abstract：:C-C chemokine receptor 7 (CCR7) and its ligands CCL19 contributes to the directional migration of certain cancer cell lines, but its role in the migration of BMSCs remains vague. The aim of this study was to determine the possible interaction between CCL19-induced conditions and matrix metalloproteinases-9 (MMP9) expr...

journal_title：Biochemical and biophysical research communications

authors： Zhang W,Tu G,Lv C,Long J,Cong L,Han Y

更新日期：2014-08-22 00:00:00

abstract：:Secreted frizzled-related protein 5 (Sfrp5), an anti-inflammatory adipocytokine secreted by adipocytes, plays an important role in energy metabolism. Studies have shown that Sfrp5 plays a salutary role in the regulation of lipid metabolism, but its specific mechanism needs further study. In this study, we showed a low...

journal_title：Biochemical and biophysical research communications

authors： Zhao A,Jiang F,Yang G,Liu H,Li L

更新日期：2019-04-30 00:00:00

abstract：:The BLM-Ni(III) complex preferentially cleaves guanine residues at D loop and anticodon loop of yeast tRNA(phe) by aniline treatment, whereas the BLM-Co(III) complex degrades certain 5'-AN sites of the minor groove region after irradiation of UV light. These cleavage features are clearly different from that of the BLM...

journal_title：Biochemical and biophysical research communications

authors： Guan LL,Totsuka R,Kuwahara J,Otsuka M,Sugiura Y

更新日期：1993-03-31 00:00:00

abstract：:Nearly complete cDNA clones for human aldolase A mRNA were isolated from human liver cDNA library and the nucleotide sequence determined. Using the cDNA clone as a probe the length of human aldolase A mRNAs, isolated from the skeletal muscle, liver and placenta tissues, was measured by RNA blotting and estimated to be...

journal_title：Biochemical and biophysical research communications

authors： Sakakibara M,Mukai T,Hori K

更新日期：1985-08-30 00:00:00

abstract：:Human untranslated region (UTR) databases were searched to identify novel proteins potentially regulated by an iron responsive element (IRE), and found two candidates-cell cycle phosphatase Cdc14A variant 1 and myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha), both possessing a putative IRE in ...

journal_title：Biochemical and biophysical research communications

authors： Cmejla R,Petrak J,Cmejlova J

更新日期：2006-03-03 00:00:00

abstract：:The enzymatic activity of cystathionine beta synthase has been studied in fibroblasts of nine patients with regular trisomy 21. An excess of CBS activity was found in trisomy 21 with a trisomy 21/normal ratio equal to 1.66. A 1.04 ratio was found in 21q21----21 p ter monosomy; a 1.04 and 0.99 ratio was found in two 21...

journal_title：Biochemical and biophysical research communications

authors： Chadefaux B,Rethoré MO,Raoul O,Ceballos I,Poissonnier M,Gilgenkranz S,Allard D

更新日期：1985-04-16 00:00:00

abstract：:The specificity of alpha, beta-methylene-ATP for P2X receptor binding sites in the CNS has been examined by testing the effects of several ATP analogues and other ATP-related substances on the binding of 10 nM [3H]alpha,beta-methylene-ATP to 20 microns thick sections of fresh-frozen rat brain. The labelling of the put...

journal_title：Biochemical and biophysical research communications

authors： Worthington RA,Hansen MA,Bennett MR,Barden JA,Balcar VJ

更新日期：1998-08-10 00:00:00

abstract：:Transglutaminase inhibitor (1,3,4,5-tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride or L-682777) affected the appearance of the fertilization envelope (FE) and subsequent development in Sphaerechinus granularis and Arbacia punctulata in a concentration-dependent manner. Abnormalities were first visible in formin...

journal_title：Biochemical and biophysical research communications

authors： Cariello L,Zanetti L,Lorand L

更新日期：1994-11-30 00:00:00

abstract：:The effect of the interleukin-1 receptor antagonist (IL-1ra) on development of hyperglycemia and insulitis in mice treated with multiple low doses of streptozotocin (STZ) was evaluated. C57BL/Ks mice were subjected to the following treatments: 1) Injections i.p. of phosphate-buffered saline (PBS) alone; 2) STZ (5 x 40...

journal_title：Biochemical and biophysical research communications

authors： Sandberg JO,Andersson A,Eizirik DL,Sandler S

更新日期：1994-07-15 00:00:00

abstract：:The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane seg...

journal_title：Biochemical and biophysical research communications

authors： Galindo BE,de la Vega-Beltrán JL,Labarca P,Vacquier VD,Darszon A

更新日期：2007-03-16 00:00:00

abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

journal_title：Biochemical and biophysical research communications

authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

更新日期：1990-12-31 00:00:00

abstract：:Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. Mechanisms of antithrombin's effects on neutrophils were, therefore, studied by testing function and expression of heparan sulfate proteoglycans in RT-PCR or flow cytometry and cell migratio...

journal_title：Biochemical and biophysical research communications

authors： Kaneider NC,Egger P,Dunzendorfer S,Wiedermann CJ

更新日期：2001-09-14 00:00:00

abstract：:Extensive evidence suggests that reactive oxygen species are critically involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and myocardial ischemia-reperfusion injury. Consistent with this concept, administration of exogenous antioxidants has been shown to be protective against oxidative c...

journal_title：Biochemical and biophysical research communications

authors： Cao Z,Li Y

更新日期：2002-03-22 00:00:00

abstract：:Mouse peritoneal macrophages metabolize dihomogammalinolenic acid (20:3n-6) primarily to 15-hydroxy-8,11,13-eicosatrienoic acid (15-OH-20:3). Since the biological properties of this novel trienoic eicosanoid remain poorly defined, the effects of increasing concentrations of 15-OH-20:3 and its arachidonic acid (20:4n-6...

journal_title：Biochemical and biophysical research communications

authors： Chapkin RS,Miller CC,Somers SD,Erickson KL

更新日期：1988-06-16 00:00:00

abstract：:We have previously characterized the effects of 2,6-diisopropylphenyl-docosahexaenoamide (DIP-DHA) conjugates and their analogs on the proliferation and progression of breast cancer cell lines. For this study, we investigated the effects of the DIP-DHA conjugate on 2 representative T cell acute lymphoblastic leukemia ...

journal_title：Biochemical and biophysical research communications

authors： Altenburg JD,Harvey KA,McCray S,Xu Z,Siddiqui RA

更新日期：2011-07-29 00:00:00

abstract：:The concept of endothelium-derived relaxing factor (EDRF) implies that nitric oxide (NO) produced by NO synthase (NOS) in the endothelium in response to vasorelaxants such as acetylcholine (ACh) acts on the underlying vascular smooth muscle cells (VSMC) inducing vascular relaxation. The EDRF concept was derived from e...

journal_title：Biochemical and biophysical research communications

authors： Buchwalow IB,Cacanyiova S,Neumann J,Samoilova VE,Boecker W,Kristek F

更新日期：2008-12-12 00:00:00

abstract：:The fibroblast growth factors (FGFs) are involved in hematopoiesis and tumorigenesis. However, little is known about the contribution of the FGFs identified within the past 10 years to leukemogenesis. To elucidate whether these FGFs (FGF-8, -9, -10, -11, -12, -13, -14, -16, -17, -18, -19, -20, and -21) are expressed i...

journal_title：Biochemical and biophysical research communications

authors： Nezu M,Tomonaga T,Sakai C,Ishii A,Itoga S,Nishimura M,Matsuo Y,Tagawa M,Nomura F

更新日期：2005-09-30 00:00:00

abstract：:Influenza A viruses are a major threat to human health and inflict a significant public health challenge worldwide. Hemagglutinin (HA) is the main contributor to the infectivity of the virus and is a potential target for the development of antiviral therapeutic agents. The stem region of HA, which has been shown to be...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Wang H,Sun L,Liu Y,Sun J,Zhao X,Li Y,Xie X,Hu J

更新日期：2019-10-15 00:00:00

abstract：:Little is known about determinants regulating expression of Mannan-binding lectin associated serine protease-2 (MASP-2), the effector component of the lectin pathway of complement activation. Comparative bioinformatic analysis of the MASP2 promoter regions in human, mouse, and rat, revealed conservation of two putativ...

journal_title：Biochemical and biophysical research communications

authors： Unterberger C,Hanson S,Klingenhoff A,Oesterle D,Frankenberger M,Endo Y,Matsushita M,Fujita T,Schwaeble W,Weiss EH,Ziegler-Heitbrock L,Stover C

更新日期：2007-12-28 00:00:00

abstract：:We studied the regulation of glutathione (GSH) synthesis and characterised the 5'-promoter region of the gamma-glutamylcysteine synthetase-heavy subunit (gammaGCS-HS) gene in human alveolar type II cells (A549) following exposure to menadione (MQ) and hydrogen peroxide (H2O2). Both MQ (100 microM) and H2O2 (100 microM...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Bel A,Mulier B,Lawson MF,Harrison DJ,Macnee W,Smith CA

更新日期：1996-12-24 00:00:00

abstract：:5-Lipoxygenase is the key enzyme in the biosynthesis of leukotrienes, powerful lipid mediators involved in inflammation, cell-cell communication, and other important physiological and pathological conditions. Particularly, cysteinyl-leukotrienes have been recognized as playing a significant role in the pathophysiology...

journal_title：Biochemical and biophysical research communications

authors： Ramires R,Caiaffa MF,Tursi A,Haeggström JZ,Macchia L

更新日期：2004-11-12 00:00:00

abstract：:Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-...

journal_title：Biochemical and biophysical research communications

authors： Kuroda M,Onoyama R,Sasaki W,Sebe M,Kitamura T,Masumoto S,Tsutsumi R,Harada N,Sakaue H

更新日期：2020-02-16 00:00:00

abstract：:Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolishe...

journal_title：Biochemical and biophysical research communications

authors： Kniep B,Peter-Katalinić J,Flegel W,Northoff H,Rieber EP

更新日期：1992-09-30 00:00:00

abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

journal_title：Biochemical and biophysical research communications

authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

更新日期：1995-07-17 00:00:00

abstract：:We investigated the mechanisms by which the heat shock response inhibits inducible nitric oxide synthase (iNOS) gene expression. Incubation of cultured murine lung epithelium (MLE-15) at temperatures ranging from 39 to 43 degrees C, for 1 h, demonstrated that only severe thermal stress (41 to 43 degrees C) was suffici...

journal_title：Biochemical and biophysical research communications

authors： Wong HR,Ryan M,Wispé JR

更新日期：1997-02-13 00:00:00