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Effects of inhibiting transglutaminase during egg fertilization and development.

Abstract：

:Transglutaminase inhibitor (1,3,4,5-tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride or L-682777) affected the appearance of the fertilization envelope (FE) and subsequent development in Sphaerechinus granularis and Arbacia punctulata in a concentration-dependent manner. Abnormalities were first visible in forming FE's at the lowest concentration (0.001 mM) of the inhibitor used. The wrinkled appearance of FE's suggested that the treatment prevented the I-T transition, whereas the finding of numerous denuded cells and empty FE's indicated that the inhibitor acted by rendering the FE's very fragile. Cell division by the 2-cell stage was also affected by this active-site-directed transglutaminase inhibitor. With 0.05 mM of the inhibitor, about 50% of all cells were polynucleated. In view of earlier findings that other transglutaminase inhibitors can produce abnormalities with regard to FE wrinkling and deranged cell division, it can be suggested that different forms of transglutaminases might be involved at various stages in embryonic development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cariello L,Zanetti L,Lorand L

doi

10.1006/bbrc.1994.2702

subject

Has Abstract

pub_date

1994-11-30 00:00:00

pages

565-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72702-1

journal_volume

205

pub_type

杂志文章

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