Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice.

abstract：:A novel assay for selective determination of polynucleotides using atomic force microscopy in conjunction with the formation of the probe/target/DNA-gold nanoparticle sandwich structure at a gold surface is described. A 17-mer probe was attached to the surface for subsequent hybridization with a polynucleotide target....

journal_title：Biochemical and biophysical research communications

authors： Han S,Lin J,Zhou F,Vellanoweth RL

更新日期：2000-12-09 00:00:00

abstract：:Two alternatively spliced Caenorhabditis elegans G protein-coupled receptors, T19F4.1a and T19F4.1b, were cloned and functionally characterized. The T19F4.1b receptor protein is 30 amino acids longer than T19F4.1a, and the difference in amino acid constitution is exclusively conferred to the intracellular C-terminal r...

journal_title：Biochemical and biophysical research communications

authors： Mertens I,Meeusen T,Janssen T,Nachman R,Schoofs L

更新日期：2005-05-13 00:00:00

abstract：:Until now, voltage-gated Ca(2+) channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca(2+) channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in i...

journal_title：Biochemical and biophysical research communications

authors： Durell SR,Guy HR

更新日期：2001-03-02 00:00:00

abstract：:The ferromagnetic transduction model proposed by J.L. Kirschvink (Phys. Rev. A (1992) 46, 2178-2184) suggests that the coupling of biogenic magnetic particles in the human brain to mechanosensitive membrane ion gates may provide a mechanism for interactions of environmental magnetic fields with humans. Extremely low f...

journal_title：Biochemical and biophysical research communications

authors： Dobson J,St Pierre T

更新日期：1996-10-23 00:00:00

abstract：:This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate o...

journal_title：Biochemical and biophysical research communications

authors： Hornicek FJ,Malinin GI,Malinin TI

更新日期：1992-02-28 00:00:00

abstract：:The effects of etomoxir, an irreversible carnitine palmitoyltransferase I inhibitor, on the liver protein pattern and on liver morphology were examined by two-dimensional gel electrophoresis in female Sprague-Dawley rats treated with 125 mg/kg/day etomoxir for 28 days. In livers of treated animals a protein spot was f...

journal_title：Biochemical and biophysical research communications

authors： Steiner S,Wahl D,Mangold BL,Robison R,Raymackers J,Meheus L,Anderson NL,Cordier A

更新日期：1996-01-26 00:00:00

abstract：:Systemic injections of AAV vectors generally transduce to the liver more effectively than to cardiac and skeletal muscles. The short hairpin RNA (shRNA)-expressing AAV9 (shRNA-AAV9) can also reduce target gene expression in the liver, but not enough in cardiac or skeletal muscles. Higher doses of shRNA-AAV9 required f...

journal_title：Biochemical and biophysical research communications

authors： Mayra A,Tomimitsu H,Kubodera T,Kobayashi M,Piao W,Sunaga F,Hirai Y,Shimada T,Mizusawa H,Yokota T

更新日期：2011-02-11 00:00:00

abstract：:Molecular mechanisms relating interferon-alpha (IFN-alpha) to brain damage have recently been identified in a microarray analysis of cerebrospinal fluid lymphocytes from patients with Aicardi-Goutières Syndrome (AGS). These findings demonstrate that the inhibition of angiogenesis and the activation of neurotoxic lymph...

journal_title：Biochemical and biophysical research communications

authors： Pulliero A,Marengo B,Longobardi M,Fazzi E,Orcesi S,Olivieri I,Cereda C,Domenicotti C,Balottin U,Izzotti A

更新日期：2013-01-18 00:00:00

abstract：:Increasing the number of transcription factor binding sites within a construct can enhance expression. In an attempt to create a synthetic locus control region for mammary expression, we have generated beta-lactoglobulin-reporter constructs with multiple copies of the cluster of transcription sites normally located wi...

journal_title：Biochemical and biophysical research communications

authors： James RM,Neil C,Webster J,Roos S,Clark AJ,Whitelaw CB

更新日期：2000-05-27 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine which is highly expressed in skeletal muscle, and which stimulates muscle protein accretion in cultured skeletal muscle fibers. Using parental C2 skeletal myoblasts, no significant effects of IL-15 on skeletal muscle differentiation were observed. To test the hypothesis that IL-15 ...

journal_title：Biochemical and biophysical research communications

authors： Quinn LS,Haugk KL,Damon SE

更新日期：1997-10-09 00:00:00

abstract：:The control of cellular adhesion to extracellular matrix proteins is poorly understood. In the present analyses, we set out to test the hypothesis that high galectin-3 concentration on the cell surface downregulates cellular adhesion to the extracellular matrix proteins. Various tumor cell lines were briefly incubated...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Leite-Browning ML,Warfield P

更新日期：1998-05-29 00:00:00

abstract：:Sugars will eventually be exported transporters (SWEETs) are a group of recently identified sugar transporters in plants that play important roles in diverse physiological processes. However, currently, limited information about this gene family is available in pineapple (Ananas comosus). The availability of the recen...

journal_title：Biochemical and biophysical research communications

authors： Guo C,Li H,Xia X,Liu X,Yang L

更新日期：2018-02-05 00:00:00

abstract：:Amino acid transporter plays an important role in regulating mTOR signaling pathway. This study investigated the effects of reduced dietary protein levels on amino acid transporters and mTOR signaling pathway. A total of 54 weaning pigs were randomly allocated into a 3 × 3 factorial design, followed by slaughtering th...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Wan X,Peng J,Xiong Q,Niu H,Li H,Chai J,Jiang S

更新日期：2017-04-01 00:00:00

abstract：:Progesterone (Pg) is an essential steroid hormone during mammary gland development and tumorigenesis, including the maintenance of epithelial stem/progenitor cells. Pg functions through interaction with the progesterone receptors (PR) and Pg-PR signaling is thought to be mediated by key transcription factors, which ar...

journal_title：Biochemical and biophysical research communications

authors： Li M,Zhao D,Ma G,Zhang B,Fu X,Zhu Z,Fu L,Sun X,Dong JT

更新日期：2013-01-04 00:00:00

abstract：:It was previously shown that 5-hexyne-1,4-diamine is a potent enzyme-activated irreversible inhibitor of mammalian ornithine decarboxylase. However this compound has secondary pharmacological effects owing to its in vivo oxidation to 4-aminohex-5-ynoic acid, an irreversible inhibitor of 4-aminobutyrate aminotransferas...

journal_title：Biochemical and biophysical research communications

authors： Danzin C,Casara P,Claverie N,Metcalf BW,Jung MJ

更新日期：1983-10-14 00:00:00

abstract：:Partial 3'-end nucleotide sequence of the pkI gene (GenBank accession No. AF019143) from Photobacterium leiognathi ATCC 25521 has been determined, and the encoded pyruvate kinase I is deduced. Pyruvate kinase I is the key enzyme of glycolysis, which converts phosphoenol pyruvate to pyruvate. Alignment and comparison o...

journal_title：Biochemical and biophysical research communications

authors： Lin JW,Lu HC,Chen HY,Weng SF

更新日期：1997-10-09 00:00:00

abstract：:We describe the fusion of enhanced green fluorescent protein to the C-terminus of the HsdS DNA sequence-specificity subunit of the Type I DNA modification methyltransferase M.EcoKI. The fusion expresses well in vivo and assembles with the two HsdM modification subunits. The fusion protein functions as a sequence-speci...

journal_title：Biochemical and biophysical research communications

authors： Chen K,Roberts GA,Stephanou AS,Cooper LP,White JH,Dryden DT

更新日期：2010-07-23 00:00:00

abstract：:The major bovine seminal plasma protein, PDC-109, binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids (cholesterol efflux), which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against ...

journal_title：Biochemical and biophysical research communications

authors： Singh BP,Saha I,Nandi I,Swamy MJ

更新日期：2017-12-02 00:00:00

abstract：:Formate dehydrogenase ( FDH ) from Clostridium thermoaceticum is a known tungsten enzyme. FDH was tested for the presence of nitrogenase-type cofactor and nitrate reductase-type cofactor by the Azotobacter vinelandii UW-45 and Neurospora crassa nit-1 reconstitution assays, respectively. Tungsten formate dehydrogenase ...

journal_title：Biochemical and biophysical research communications

authors： Deaton JC,Solomon EI,Durfor CN,Wetherbee PJ,Burgess BK,Jacobs DB

更新日期：1984-06-29 00:00:00

abstract：:The aim of this study was to explore the effect of the acetylcholinesterase inhibiting mixture of extracts of Angelica archangelica fruit and Geranium sylvaticum on memory. Furthermore the effect of the main compound, the furanocoumarin imperatorin, which has been shown to affect several neurotransmitters, was studied...

journal_title：Biochemical and biophysical research communications

authors： Sigurdsson S,Gudbjarnason S

更新日期：2013-11-15 00:00:00

abstract：:The effect of transforming growth factor-beta (TGF-beta) on the endogenous protein phosphorylation caused by phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), was examined in primary cultured mouse epidermal cells. PMA markedly stimulates phosphorylation of endogenous proteins, i.e. ...

journal_title：Biochemical and biophysical research communications

authors： Nishikawa K,Yamamoto S,Nagumo H,Otsuka C,Kato R

更新日期：1993-05-28 00:00:00

abstract：:A biotin-polyethylene glycol (PEG)-epidermal growth factor (EGF) conjugate was immobilized onto the surface of avidin-modified adenovirus (ADV-Avi) via biotin-avidin interaction to deliver ADV specifically to EGF receptor over-expressing cancer cells. ADV-Avi/biotin-PEG-EGF complexes showed greatly enhanced intracellu...

journal_title：Biochemical and biophysical research communications

authors： Park JW,Mok H,Park TG

更新日期：2008-02-15 00:00:00

abstract：:p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, to...

journal_title：Biochemical and biophysical research communications

authors： Agostini M,Tucci P,Chen H,Knight RA,Bano D,Nicotera P,McKeon F,Melino G

更新日期：2010-12-03 00:00:00

abstract：:It has been proposed that the inositol 1,4,5-trisphosphate receptor (InsP(3)R) type III acts as a trigger for InsP(3)-mediated calcium (Ca(2+)) signaling, because this InsP(3) isoform lacks feedback inhibition by cytosolic Ca(2+). We tested this hypothesis in RIN-m5F cells, which express predominantly the type III rec...

journal_title：Biochemical and biophysical research communications

authors： O'Neill AF,Hagar RE,Zipfel WR,Nathanson MH,Ehrlich BE

更新日期：2002-06-14 00:00:00

abstract：:The transcription of a mouse genomic segment containing four tRNA genes, coding for a tRNA(Ala), a tRNA(Ile), a tRNA(Pro) and a tRNA(Lys), has been studied in a HeLa cell extract, demonstrating that differences among their transcriptional efficiencies are evident using as templates either the natural cluster or an equ...

journal_title：Biochemical and biophysical research communications

authors： Russo T,Oliva A,Duilio A,Ammendola R,Costanzo F,Zannini M,Cimino F

更新日期：1987-12-31 00:00:00

abstract：:l-Aspartyl (l-Asp) and l-asparaginyl residues in proteins isomerize or racemize to d,l-isoaspartyl (d,l-isoAsp) or d-aspartyl (d-Asp) residues during protein aging. These atypical aspartyl residues can interfere with the biological function of the protein and lead to cellular dysfunction. Protein l-isoaspartyl (d-aspa...

journal_title：Biochemical and biophysical research communications

authors： Kosugi S,Furuchi T,Katane M,Sekine M,Shirasawa T,Homma H

更新日期：2008-06-20 00:00:00

abstract：:To identify genes responding to the cholesterol-rich diet, differentially expressed hepatic genes have been searched from a diet-induced hypercholesterolemic rabbit by differential display reverse transcription-polymerase chain reaction (DDRT-PCR). Among the many screened genes, Rab7 gene was shown to be distinctively...

journal_title：Biochemical and biophysical research communications

authors： Kim JY,Jang MK,Lee SS,Choi MS,Bok SH,Oh GT,Park YB

更新日期：2002-04-26 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers and is the second-leading cause of cancer-associated morbidity worldwide. Oxysterols are oxidized derivatives of cholesterol that may be important in many biological processes, but the levels and roles of oxysterols in gastric tumours remain to be elucidated. The l...

journal_title：Biochemical and biophysical research communications

authors： Guo F,Hong W,Yang M,Xu D,Bai Q,Li X,Chen Z

更新日期：2018-10-12 00:00:00

abstract：:Altering the carbohydrate binding properties of surfactant protein D (SP-D) [e.g., by replacing its carbohydrate recognition domain (CRD) with that of either mannose binding lectin (MBL) or conglutinin] can increase its activity against influenza A virus (IAV). The current study demonstrates that the degree of multime...

journal_title：Biochemical and biophysical research communications

authors： White MR,Crouch E,Chang D,Hartshorn KL

更新日期：2001-08-10 00:00:00

abstract：:Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secretion in macrophage...

journal_title：Biochemical and biophysical research communications

authors： Zhang T,Du H,Feng S,Wu R,Chen T,Jiang J,Peng Y,Ye C,Fang R

更新日期：2019-06-04 00:00:00