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p73 regulates maintenance of neural stem cell.

Abstract：

:p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Agostini M,Tucci P,Chen H,Knight RA,Bano D,Nicotera P,McKeon F,Melino G

doi

10.1016/j.bbrc.2010.10.087

subject

Has Abstract

pub_date

2010-12-03 00:00:00

pages

13-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01976-5

journal_volume

403

pub_type

杂志文章

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