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The transcriptional efficiency of clustered tRNA genes is affected by their position within the cluster.

Abstract：

:The transcription of a mouse genomic segment containing four tRNA genes, coding for a tRNA(Ala), a tRNA(Ile), a tRNA(Pro) and a tRNA(Lys), has been studied in a HeLa cell extract, demonstrating that differences among their transcriptional efficiencies are evident using as templates either the natural cluster or an equimolecular mixture of the four isolated genes. Nevertheless, the structure of the cluster influences the transcriptional efficiency of the clustered genes. In fact, a cis-acting inhibitory sequence has been located at about 400 bp downstream of the tRNA(Pro) coding sequence. Moreover rearrangements of the reciprocal position of the various tRNA genes within the cluster results in significant changes in the transcriptional rates of the individual transcriptional units.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Russo T,Oliva A,Duilio A,Ammendola R,Costanzo F,Zannini M,Cimino F

doi

10.1016/0006-291x(87)90524-9

subject

Has Abstract

pub_date

1987-12-31 00:00:00

pages

1118-24

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90524-9

journal_volume

149

pub_type

杂志文章

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