Calcium ion-regulated phospholipase C activity in bovine rod outer segments.

Abstract:

:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and accounted for 91 +/- 4 nmoles hydrolyzed/min/mg of protein. The results support the notion that in vivo the enzyme(s) is regulated so as to conform to the phototransduction events.

authors

Panfoli I,Morelli A,Pepe I

doi

10.1016/s0006-291x(05)81054-x

subject

Has Abstract

pub_date

1990-11-30 00:00:00

pages

283-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81054-X

journal_volume

173

pub_type

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