Abstract:
:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and accounted for 91 +/- 4 nmoles hydrolyzed/min/mg of protein. The results support the notion that in vivo the enzyme(s) is regulated so as to conform to the phototransduction events.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Panfoli I,Morelli A,Pepe Idoi
10.1016/s0006-291x(05)81054-xsubject
Has Abstractpub_date
1990-11-30 00:00:00pages
283-8issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(05)81054-Xjournal_volume
173pub_type
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journal_title:Biochemical and biophysical research communications
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更新日期:2017-01-01 00:00:00