PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.

abstract：:Specific, saturable EGF receptors were demonstrated in isolated rat pancreatic acini. Binding of EGF to these receptors was one-half maximal at 20 min and maximal at 120 min. Scatchard analyses revealed a single order of binding sites with a Kd of 4.90 nM. Following binding, EGF was rapidly internalized and converted ...

journal_title：Biochemical and biophysical research communications

authors： Korc M,Matrisian LM,Planck SR,Magun BE

更新日期：1983-03-29 00:00:00

abstract：:An infection of any part of female reproductive tract can severely interfere with fertility and reproduction. The fluids and epithelium from the lumen of the female reproductive tract (uterus, oviduct and ovarian follicle) are a known source of antimicrobial action in several species. In this study, we compared the an...

journal_title：Biochemical and biophysical research communications

authors： Dráb T,Kračmerová J,Hanzlíková E,Černá T,Litváková R,Pohlová A,Tichá M,Přikryl P,Liberda J

更新日期：2014-01-17 00:00:00

abstract：:The soil fungus Mucor genevensis was shown to convert exogenous arachidonic acid to the oxylipin 3-hydroxy-5Z,8Z-tetradecadienoic acid (3-HTDE) as determined by gas chromatography/mass spectrometry. This metabolite was only found in the aqueous supernatant together with free linoleic acid, but not in the final fungal ...

journal_title：Biochemical and biophysical research communications

authors： Pohl CH,Botha A,Kock JL,Coetzee DJ,Botes PJ,Schewe T,Nigam S

更新日期：1998-12-30 00:00:00

abstract：:Free methionine-R-sulfoxide reductase (fRMsr) is a new type of methionine sulfoxide reductase that catalyzes the reduction of free methionine-R-sulfoxide to methionine. This enzyme cannot reduce oxidized methionine residues in proteins. While three Cys residues, Cys-91, Cys-101 and Cys-125, have been demonstrated to b...

journal_title：Biochemical and biophysical research communications

authors： Kwak GH,Kim MJ,Kim HY

更新日期：2010-05-07 00:00:00

abstract：:The clinical effects of serpin polymerisation include thromboembolism, emphysema, and liver disease. A through understanding of serpin polymerisation mechanisms and the structures involved will permit the rational design of therapeutic polymerisation inhibitors. Here we show that serpin polymerisation can be delayed b...

journal_title：Biochemical and biophysical research communications

authors： Bottomley SP,Chang WS

更新日期：1997-12-18 00:00:00

abstract：:Guanine nucleotides and monovalent cations decrease the affinity of cardiac muscarinic receptors for agonists and are required for muscarinic receptor mediated inhibition of adenylate cyclase. N-ethylmaleimide abolished the effects of Gpp(NH)p on the ability of the agonist oxotremorine to inhibit the binding of the an...

journal_title：Biochemical and biophysical research communications

authors： McMahon KK,Hosey MM

更新日期：1983-02-28 00:00:00

abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

journal_title：Biochemical and biophysical research communications

authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

更新日期：2006-06-30 00:00:00

abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Tamura S,Takagi H

更新日期：1985-01-16 00:00:00

abstract：:The anthrax lethal factor (LF) is a Zn(2+)-endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N-terminal region. Much line of effort was carried out to elucidate the catalytic activity of LF for designing the inhibitor and to understand the cellular mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Chai YG,Yoon MY

更新日期：2004-01-02 00:00:00

abstract：:Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene, are the major cause of X-linked retinitis pigmentosa (RP), in which exon open reading frame 15 (ORF15) of RPGR has been implicated to play a substantial role. We identified a novel hemizygous missense mutation E585K of RPGR from whole-exome sequencing...

journal_title：Biochemical and biophysical research communications

authors： Liu YS,Pan JQ,Wan JF,Ren CY,Xu ZH,Pan XB,Gao RN,Liu SQ,Zhang JL,Yao QH,Wang JH,Li EM,Rao JH,Hou P,Chen JH

更新日期：2020-10-15 00:00:00

abstract：:Crystallographic studies have shown independent binding sites for sugar and peptide ligands of concanavalin A, although they were considered functional mimics based on biochemical experiments. The topological correlation of 12-residue peptide with different carbohydrate ligands of concanavalin A showed similarity betw...

journal_title：Biochemical and biophysical research communications

authors： Jain D,Kaur KJ,Goel M,Salunke DM

更新日期：2000-06-16 00:00:00

abstract：:Adipose tissue plays a key role in the development of obesity and diabetes. Natural products are one of the main sources for discovering new lead compounds. In the present study, (2S)-7,4'-dihydroxy-8-prenylflavan (DHPF), a natural prenylated flavan isolated from Morus yunnanensis, was found to significantly promote a...

journal_title：Biochemical and biophysical research communications

authors： Ji J,Zhu J,Hu X,Wang T,Zhang X,Hou AJ,Wang H

更新日期：2015-05-08 00:00:00

abstract：:Plasma membrane fractions from mouse livers were examined for the presence of growth regulatory peptides. Both growth inhibitory and growth stimulatory factors were found on these membranes. The growth inhibitory component could be enriched by extractions with both dimethylmaleic anhydride and octylglucoside. The grow...

journal_title：Biochemical and biophysical research communications

authors： Lieberman MA

更新日期：1984-05-16 00:00:00

abstract：:Fecal supernatant or serum containing TT virus (TTV) of genotype 1a (10(5) copies/ml) from patients with acute TTV infection was inoculated intravenously into two naive chimpanzees. Serum samples were obtained weekly and tested for TTV DNA by genotype 1-specific polymerase chain reaction. TTV DNA was detected in chimp...

journal_title：Biochemical and biophysical research communications

authors： Tawara A,Akahane Y,Takahashi M,Nishizawa T,Ishikawa T,Okamoto H

更新日期：2000-11-19 00:00:00

abstract：:Trypsin-like serine proteases are involved in diverse biological processes such as complement activation, tissue remodeling, cellular migration, tumor invasion, and metastasis. Here we report a novel human C1r-like serine protease analog, CLSPa, derived from dendritic cells (DC). The 487-residue CLSPa protein contains...

journal_title：Biochemical and biophysical research communications

authors： Lin N,Liu S,Li N,Wu P,An H,Yu Y,Wan T,Cao X

更新日期：2004-08-20 00:00:00

abstract：:Angiogenesis plays a pivotal role in gastric ulcer repair. Several growth factors are involved in angiogenesis, and of these, vascular endothelial growth factor (VEGF) has received considerable attention, since it is the only factor that specifically acts on endothelial cells. However, the role of VEGF in gastric ulce...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Kawabe T,Ogura K,Maeda S,Mikami Y,Kaneko N,Terano A,Omata M

更新日期：1997-05-19 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:Arrhythmogenic right ventricular dysplasia/cardiomyopathy type 2 (ARVD2, OMIM 600996) and stress-induced polymorphic ventricular tachycardia (VTSIP, OMIM 604772) are two cardiac diseases causing juvenile sudden death, both associated with mutations in the RyR2 calcium channel. By using a quantitative yeast two-hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Tiso N,Salamon M,Bagattin A,Danieli GA,Argenton F,Bortolussi M

更新日期：2002-12-13 00:00:00

abstract：:The regulatory mechanisms of most cyclin dependent protein kinases (CDKs) are well understood and are highly conserved in eukaryotes. CDKs from the malaria parasite, Plasmodium falciparum, appear to be regulated in a similar manner with regard to cyclin binding and phosphorylation. In order to further understand their...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Le Roch K,Geyer JA,Woodard CL,Prigge ST,Koh J,Doerig C,Waters NC

更新日期：2001-11-16 00:00:00

abstract：:p120-Catenin is known to play important roles in cell-cell adhesion stability by binding to cadherin and morphological changes of cells by regulating small RhoGTPase activities. Although the expression and binding states of p120-catenin are thought to dynamically change due to morphological adaptation of endothelial c...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto N,Segawa K,Kanzaki M,Ohashi T,Sato M

更新日期：2010-07-30 00:00:00

abstract：:Inducible nitric oxide (NO) synthase (iNOS), heme oxygenase (HO)-1, and indoleamine 2,3-dioxygenase (IDO) are simultaneously expressed in murine macrophages stimulated with interferon (IFN)-gamma and lipopolysaccharide (LPS). NO produced by iNOS suppresses IDO expression and also induces HO-1 expression. The antioxida...

journal_title：Biochemical and biophysical research communications

authors： Oh GS,Pae HO,Choi BM,Chae SC,Lee HS,Ryu DG,Chung HT

更新日期：2004-08-06 00:00:00

abstract：:Although compelling data have demonstrated the effectiveness of estrogen replacement therapy for the treatment of accelerated bone loss in postmenopausal osteoporosis and ovariectomized animals, the mechanisms by which estrogens reduce bone resorption remain to be elucidated. To address this issue, in the present stud...

journal_title：Biochemical and biophysical research communications

authors： Zecchi-Orlandini S,Formigli L,Tani A,Benvenuti S,Fiorelli G,Papucci L,Capaccioli S,Orlandini GE,Brandi ML

更新日期：1999-02-24 00:00:00

abstract：:Platelets play essential roles in hemostasis and thrombosis by aggregating with each other. However, the molecular mechanism governing platelet aggregation is not yet fully understood. Here, we established an assay system using platelets permeabilized with streptolysin-O to analyze mechanism of the thrombin-induced ag...

journal_title：Biochemical and biophysical research communications

authors： Nishioka H,Horiuchi H,Tabuchi A,Yoshioka A,Shirakawa R,Kita T

更新日期：2001-02-02 00:00:00

abstract：:Syntaxins are a family of membrane proteins believed to participate in docking/fusing of arriving vesicles during membrane sorting and secretion. Of the six mammalian syntaxins known, only brain syntaxin 1A/1B has been biochemically characterized in its endogenous form. Syntaxin 4 mRNA is expressed in selective tissue...

journal_title：Biochemical and biophysical research communications

authors： Sumitani S,Ramlal T,Liu Z,Klip A

更新日期：1995-08-15 00:00:00

abstract：:We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression...

journal_title：Biochemical and biophysical research communications

authors： Guo Y,Liu S,Zhang X,Wang L,Zhang X,Hao A,Han A,Yang J

更新日期：2014-04-18 00:00:00

abstract：:Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein). It binds to GTP/GDP and contains a low intrinsic GTPase activity. Its function remains elusive, although it has been suggested that Era is associated with the cytoplasmic membrane, cell div...

journal_title：Biochemical and biophysical research communications

authors： Sayed A,Matsuyama Si,Inouye M

更新日期：1999-10-14 00:00:00

abstract：:Eicosanoid formation by transcellular routes can amplify the levels and types of lipid mediators within a local milieu. To evaluate the role of adhesion in this process, we assessed the influence of mAb against adhesion molecules on LTC4 generation by PMN-endothelial cell interaction. Transcellular LTC4 generation was...

journal_title：Biochemical and biophysical research communications

authors： Brady HR,Serhan CN

更新日期：1992-08-14 00:00:00

abstract：:Streptococcus mutans secretes a sucrose-independent branalphang enzyme that utilizes isomaltosaccharides as donors for branalphang formation on dextran. Although the branching enzyme is necessary for the formation of extracellular polysaccharide complexes, the source of the donor for the enzyme is unknown. In this stu...

journal_title：Biochemical and biophysical research communications

authors： Yamashita Y,Hanada N,Takehara T

更新日期：1988-01-29 00:00:00

abstract：:We have compared the coupling of human alpha(1A)-, alpha(1B)-, and alpha(1D)-adrenoceptors (expressed at approximately 2000 fmol/mg protein in Chinese hamster ovary cells) to cellular growth promotion (as assessed by [(3)H]thymidine incorporation) and related signaling mechanisms. Maximum elevation of intracellular Ca...

journal_title：Biochemical and biophysical research communications

authors： Keffel S,Alexandrov A,Goepel M,Michel MC

更新日期：2000-06-16 00:00:00

abstract：:Ezetimibe is a cholesterol-lowering agent targeting Niemann-Pick C1-like 1, an intestinal cholesterol transporter. Inhibition of intestinal cholesterol absorption with ezetimibe may ameliorate several metabolic disorders including hepatic steatosis and insulin resistance. In this study, we investigated whether chronic...

journal_title：Biochemical and biophysical research communications

authors： Yang SJ,Choi JM,Kim L,Kim BJ,Sohn JH,Kim WJ,Park SE,Rhee EJ,Lee WY,Oh KW,Park SW,Kim SW,Park CY

更新日期：2011-04-01 00:00:00