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The presence of both growth inhibitory and growth stimulatory factors on membranes prepared from mouse liver.

Abstract：

:Plasma membrane fractions from mouse livers were examined for the presence of growth regulatory peptides. Both growth inhibitory and growth stimulatory factors were found on these membranes. The growth inhibitory component could be enriched by extractions with both dimethylmaleic anhydride and octylglucoside. The growth stimulatory component could be removed from the membrane by either freeze-thaw, high salt, protease or pyrophosphate treatment, indicating that this factor is an extrinsic membrane protein. The existence of these factors on liver membranes provides an easily obtainable source for the large-scale purification of these molecules and may indicate a possible role in normal tissue growth.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lieberman MA

doi

10.1016/s0006-291x(84)80191-6

subject

Has Abstract

pub_date

1984-05-16 00:00:00

pages

891-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80191-6

journal_volume

120

pub_type

杂志文章

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