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Cancer metabolism: facts, fantasy, and fiction.

Abstract：

:The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data from the last 40 years on this issue. We conclude that there is no evidence that cancer cells are inherently glycolytic, but that some tumours might indeed be glycolytic in vivo as a result of their hypoxic environment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zu XL,Guppy M

doi

10.1016/j.bbrc.2003.11.136

subject

Has Abstract

pub_date

2004-01-16 00:00:00

pages

459-65

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X0302504X

journal_volume

313

pub_type

杂志文章,评审

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