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Effects of aminoglycoside antibiotics on the coupling of protein and RNA syntheses in Escherichia coli.

Abstract：

:The interdependency of protein and RNA syntheses was studied comparatively in bacteria confronted with amino acid starvation or treated separately with various aminoglycoside antibiotics. By contrast with the concomitant inhibition of macromolecular syntheses in cells deprived of an essential amino acid, RNA production was found to continue in drug-treated cells while protein synthesis was arrested. Such uncoupling process was also observed in bacteria subjected simultaneously to amino acid starvation and treatment with certain antibiotics (neomycin, gentamicin, spectinomycin and kasugamycin) but not with others (streptomycin and kanamycin). These results were related to the intracellular concentration of guanosine polyphosphates, ppGpp and pppGpp. They were discussed in terms of interaction of aminoglycosides with ribosomes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cortay JC,Cozzone AJ

doi

10.1016/0006-291x(83)91688-1

subject

Has Abstract

pub_date

1983-05-16 00:00:00

pages

801-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91688-1

journal_volume

112

pub_type

杂志文章

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