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Identification and characterization of mouse PSF1-binding protein, SLD5.

Abstract：

:Although most somatic cells cannot proliferate, immature cells proliferate continuously to produce mature cells. Recently, we cloned mouse PSF1 from a hematopoietic stem cell specific cDNA library and reported that PSF1 is indispensable for the proliferation of immature cells. To identify the PSF1-binding protein, we used the yeast two-hybrid system with PSF1 as bait, and identified and cloned SLD5. SLD5 interacted with a central region of PSF1. Tissue distribution of SLD5 was quite similar to that of PSF1. When overexpressed, SLD5 protein was co-localized with PSF1. These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kong L,Ueno M,Itoh M,Yoshioka K,Takakura N

doi

10.1016/j.bbrc.2005.11.136

subject

Has Abstract

pub_date

2006-01-27 00:00:00

pages

1204-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02667-7

journal_volume

339

pub_type

杂志文章

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