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Activation of the c-K-ras oncogene in a human pancreas carcinoma.

Abstract：

:The human pancreas carcinoma cell line T3M-4 contains activated c-Kirsten (K)-ras oncogene detectable by the DNA-mediated gene transfer technique using NIH/3T3 cells. DNA fragments containing coding lesions have been cloned, and nucleotide sequence analysis suggests that the T3M-4 oncogene has been activated by a single nucleotide transition from A to C in the second exon, which results in the substitution of histidine for glutamine in coden 61 of the predicted amino acid sequence. The quantity analysis of c-K-ras oncogene in the DNA and RNA of T3M-4 cells revealed that the c-K-ras gene was amplified and overexpressed in T3M-4 cells. These findings indicate that the T3M-4 c-K-ras oncogene is activated by different mutational events.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hirai H,Okabe T,Anraku Y,Fujisawa M,Urabe A,Takaku F

doi

10.1016/s0006-291x(85)80140-6

subject

Has Abstract

pub_date

1985-02-28 00:00:00

pages

168-74

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)80140-6

journal_volume

127

pub_type

杂志文章

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