Abstract:
:Using a specific radioimmunoassay we have isolated and sequenced a new 45-amino acid peptide from rat atria which exhibits similar physiological and pharmacological properties to rat atrial natriuretic peptide (rANP). We have termed the new peptide iso-rANP, because of its functional and structural similarities to rANP. Amino acid sequence differences show that iso-rANP is genetically distinct from rANP. Iso-rANP has a single disulfide bond between residues 23-39 and this portion of the peptide shows substantial homology to rANP and to porcine brain natriuretic peptide (BNP). Little homology is evident at the N- and C-termini of iso-rANP and ANP. Iso-rANP is equipotent with rANP in eliciting diuresis, natriuresis and hypotension in the bioassay rat.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Flynn TG,Brar A,Tremblay L,Sarda I,Lyons C,Jennings DBdoi
10.1016/0006-291x(89)92675-2subject
Has Abstractpub_date
1989-06-15 00:00:00pages
830-7issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(89)92675-2journal_volume
161pub_type
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