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The mitogaligin protein is addressed to the nucleus via a non-classical localization signal.

Abstract：

:Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. Interaction of mitogaligin with mitochondria leads to cytochrome c cytosolic leakage and ultimately to cell death. We have previously pointed out that mitogaligin can also be directed to the nucleus when the mitochondrial addressing signal is inactivated, indicating a possible dual intracellular localization of the protein. When expressed in the nucleus, mitogaligin exhibits also apoptotic properties leading to cell death. In this report, we show that nuclear addressing of mitogaligin depends on a sequence differing from classical signals containing basic, lysine or proline-tyrosine rich residues. The signal consists of a long sequence of amino acids residues based on a series of a short repetitive degenerated sequence.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Robinet P,Mollet L,Gonzalez P,Normand T,Charpentier S,Brulé F,Dubois M,Legrand A

doi

10.1016/j.bbrc.2009.12.162

subject

Has Abstract

pub_date

2010-01-29 00:00:00

pages

53-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00003-3

journal_volume

392

pub_type

杂志文章

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