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A recombinant adenoviral vector encoding functional vasoactive intestinal peptide.

Abstract：

:Vasoactive intestinal peptide (VIP) is a small neuropeptide, which exerts pleiotropic functions. Based on its immunomodulatory, secretory, and possibly trophic effects, VIP is a valuable candidate molecule for the management of autoimmune disease. The purpose of this study was to develop a recombinant viral vector capable of directing the expression of functional VIP. The vector rAd5CMVhVIP was constructed and used to infect 293 cells. VIP expression was measured by an ELISA and function was evaluated by measurement of intracellular cAMP formation. rAd5CMVhVIP directed VIP expression and the transgenic VIP elicited a dose-dependent increase of intracellular cAMP, mediated through the VIP receptor VPAC(1). This is the first report showing the construction of a recombinant viral vector encoding biologically active VIP.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lodde BM,Delporte C,Goldsmith CM,Tak PP,Baum BJ

doi

10.1016/j.bbrc.2004.04.171

subject

Has Abstract

pub_date

2004-06-18 00:00:00

pages

189-92

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X04009325

journal_volume

319

pub_type

杂志文章

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