Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.

Abstract:

:We have isolated a cDNA encoding human epidermal transglutaminase, a key enzyme of terminal differentiation of keratinocytes. A cDNA library from cultured human keratinocytes was screened by a PCR-amplified partial cDNA fragment of the enzyme with oligonucleotide primers based on the homology of the transglutaminase family. The cDNA is 2734 bp coding a protein of 817 amino acids. The several regions including the active site cysteine residue are highly conserved among the transglutaminase family. However, the charged N-terminal domain is unique to the epidermal transglutaminse, suggesting that the region is involved in the function of the enzyme in keratinocytes.

authors

Yamanishi K,Liew FM,Konishi K,Yasuno H,Doi H,Hirano J,Fukushima S

doi

10.1016/0006-291x(91)91651-r

subject

Has Abstract

pub_date

1991-03-29 00:00:00

pages

906-13

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91651-R

journal_volume

175

pub_type

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