Kinetics of fluid-phase pinocytosis in Dictyostelium discoideum amoebae.

abstract：:EcoP1I methyltransferase (M.EcoP1I) belongs to the type III restriction-modification system encoded by prophage P1 that infects Escherichia coli. Binding of M.EcoP1I to double-stranded DNA and single-stranded DNA has been characterized. Binding to both single- and double-stranded DNA could be competed out by unlabeled...

journal_title：Biochemical and biophysical research communications

authors： Sistla S,Krishnamurthy V,Rao DN

更新日期：2004-01-30 00:00:00

abstract：:CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the antibacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, th...

journal_title：Biochemical and biophysical research communications

authors： Shin SY,Kang SW,Lee DG,Eom SH,Song WK,Kim JI

更新日期：2000-09-07 00:00:00

abstract：:The effect of 2,2,2-trifluoroethanol (TFE) on the structure of an all beta-sheet protein, cardiotoxin analogue II (CTX II), from the Taiwan cobra (Naja naja atra) is studied. Using circular dichroism studies, it is found that higher concentrations of TFE induced a structural transition from beta-sheet to alpha-helix, ...

journal_title：Biochemical and biophysical research communications

authors： Jayaraman G,Kumar TK,Arunkumar AI,Yu C

更新日期：1996-05-06 00:00:00

abstract：:The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis. Here, we investigated whether c-Src and Fak are activated during progression of hormone-dependent breast cancer. Maximally active c-Src was ...

journal_title：Biochemical and biophysical research communications

authors： Planas-Silva MD,Bruggeman RD,Grenko RT,Stanley Smith J

更新日期：2006-03-03 00:00:00

abstract：:The sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein...

journal_title：Biochemical and biophysical research communications

authors： Rosini P,De Chiara G,Lucibello M,Garaci E,Cozzolino F,Torcia M

更新日期：2000-11-30 00:00:00

abstract：:We have previously shown that a ribozyme directed against human interleukin-6 (IL-6) mRNA is efficient in vivo, despite its poor activity in vitro on full-length IL-6 mRNA. We compared the effect of the nucleocapsid protein of HIV-1 (NCp7) on the ribozyme cleavage reaction of a long (1041 nt) and a short (19 nt) subst...

journal_title：Biochemical and biophysical research communications

authors： Mahieu M,Hendrix C,Ooms J,Herdewijn P,Content J

更新日期：1995-09-05 00:00:00

abstract：:Stimulation of human T cell line Jurkat results in rapid tyrosine phosphorylation of a 35-38 kDa protein that is found in large and buoyant detergent-resistant membrane microdomains containing also glycosylphosphatidylinositol (GPI)-anchored proteins, glycolipids and Src-family protein tyrosine kinases ("GPI-microdoma...

journal_title：Biochemical and biophysical research communications

authors： Brdiĉka T,Cerný J,Horejŝí V

更新日期：1998-07-20 00:00:00

abstract：:Since conventional chemotherapy (gemcitabine and cisplatin) has marginal survival benefit in patients with advanced cholangiocarcinoma (CCA), an effective targeted therapeutic agent is urgently required. Activation of the PI3K/Akt/mTOR signaling pathway is frequently observed in CCA, and thus, PI3K and mTOR are promis...

journal_title：Biochemical and biophysical research communications

authors： Jang DK,Lee YG,Chan Chae Y,Lee JK,Paik WH,Lee SH,Kim YT,Ryu JK

更新日期：2020-09-03 00:00:00

abstract：:We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation. Ectopic expression ...

journal_title：Biochemical and biophysical research communications

authors： Yang Z,Zhang Y,Wang L

更新日期：2012-01-13 00:00:00

abstract：:Casper/c-FLIP is a caspase-8-related molecule critically involved in regulation of death receptor-induced apoptosis. It has been shown that Casper can either promote or antagonize apoptosis and can activate the transcription factor NF-kappaB. The exact functions of Casper are controversial. To further understand how C...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Zhang J,Chen D,Shu HB

更新日期：2003-10-03 00:00:00

abstract：:In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activat...

journal_title：Biochemical and biophysical research communications

authors： Renard E,Grigorescu F,Lavabre C,Kahn CR

更新日期：1995-04-06 00:00:00

abstract：:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necr...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Murakami M,Maeda H,Hibi M,Uede T

更新日期：1997-04-07 00:00:00

abstract：:We have analyzed heteroplasmy of mitochondrial DNA in clonal cultures from two patients with Kearns-Sayre syndrome, and have found that individual muscle or fibroblast clones contained either a mixed (i.e. heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e. homop...

journal_title：Biochemical and biophysical research communications

authors： Moraes CT,Schon EA,DiMauro S,Miranda AF

更新日期：1989-04-28 00:00:00

abstract：:Information about histone sequences and histone gene organization from invertebrate chordates is completely lacking. A genomic clone containing linked H3 and H4 histone genes from the urochordate Styela plicata was analyzed. The nucleotide sequence indicates that the two genes are transcribed in opposite directions an...

journal_title：Biochemical and biophysical research communications

authors： Ishaq AI,Rizvi SB,Wells DE,Tomlinson CR

更新日期：1993-07-30 00:00:00

abstract：:Caspase-8 is a key mediator in various biological processes such as apoptosis, necroptosis, inflammation, T/B cells activation, and cell motility. Caspase-8 is characterized by the N-terminal tandem death effector domains (DEDs) and the C-terminal catalytic protease domain. The DEDs mediate diverse functions of caspas...

journal_title：Biochemical and biophysical research communications

authors： Shen C,Yue H,Pei J,Guo X,Wang T,Quan JM

更新日期：2015-07-31 00:00:00

abstract：:Tripartite motif-containing protein (TRIM) family proteins are involved in a broad range of biological processes and, consistently, their alterations result in diverse pathological conditions such as genetic diseases, viral infection and cancer development. In this study, we found that one of the TRIM family proteins,...

journal_title：Biochemical and biophysical research communications

authors： Watanabe M,Tsukiyama T,Hatakeyama S

更新日期：2009-10-16 00:00:00

abstract：:Stomatal movements are regulated by alternate phase transition in the lipophilic domains of membrane initiated by blue light through activation of plasmalemma redox system. ABA blocks the blue light activated redox reactions leading to the accumulation of superoxide (O2.-) radical inducing melting of the membrane and ...

journal_title：Biochemical and biophysical research communications

authors： Purohit S,Kumar GP,Laloraya M,Laloraya MM

更新日期：1994-11-30 00:00:00

abstract：:Oxidative stress is known to play a pivotal role in the development of oral squamous cell carcinoma (OSCC). We have demonstrated that activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway has chemopreventive effects against oxidative stress-associated OSCC. However, Nrf2 have dual role...

journal_title：Biochemical and biophysical research communications

authors： Fan H,Paiboonrungruan C,Zhang X,Prigge JR,Schmidt EE,Sun Z,Chen X

更新日期：2017-11-04 00:00:00

abstract：:To study cellular and subcellular localization of TIMP-1, we constructed a cDNA which would express a chimeric protein, TIMP-1-EGFP, having the enhanced green fluorescent protein of the jelly fish Aequorea victoria fused to the carboxyl-terminus of TIMP-1. Chinese Hamster Ovary (CHO) cells were stably transfected with...

journal_title：Biochemical and biophysical research communications

authors： Ritter LM,Garfield SH,Thorgeirsson UP

更新日期：1999-04-13 00:00:00

abstract：:Chromatography of chicken liver AMP deaminase on phosphocellulose and DEAE-Sephacel revealed the existence of two separate peaks of enzyme activity. Significant differences have been observed between form I and II of the enzyme in respect to substrate specificity and their kinetic and regulatory properties. ...

journal_title：Biochemical and biophysical research communications

authors： Spychała J,Makarewicz W

更新日期：1983-08-12 00:00:00

abstract：:Phosphorylation of HMG 14 proteins from calf thymus and avian erythrocytes was studied using a cyclic GMP-dependent protein kinase from bovine lung. HMG 14 from calf thymus was a good substrate for the enzyme, but HMG 14 from avian erythrocytes was not phosphorylated. Of the potential phosphorylation sites, the one in...

journal_title：Biochemical and biophysical research communications

authors： Palvimo J,Linnala-Kankkunen A,Mäenpää PH

更新日期：1983-01-27 00:00:00

abstract：:Kurtoxin, a 63-amino acid peptide stabilized by four disulfide bonds, is the first reported peptide inhibitor of T-type voltage-gated calcium channels. Although T-type calcium channels have been implicated in a number of disease states, including epilepsy, chronic pain, hypertension and cancer, the lack of selective i...

journal_title：Biochemical and biophysical research communications

authors： Lee CW,Eu YJ,Min HJ,Cho EM,Lee JH,Kim HH,Nah SY,Swartz KJ,Kim JI

更新日期：2011-12-16 00:00:00

abstract：:To determine whether the two domains of hepatitis C virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins--the NS3H protein, containing only the helicase domain, the full-leng...

journal_title：Biochemical and biophysical research communications

authors： Kuang WF,Lin YC,Jean F,Huang YW,Tai CL,Chen DS,Chen PJ,Hwang LH

更新日期：2004-04-23 00:00:00

abstract：:A family of proteins, Homers 1, 2 and 3, involved in activity-dependent control of signal transduction has been recently described in neurons [Xiao, B., Tu, C. J., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., and Worley, P. F. (1998) Homer regulates the associat...

journal_title：Biochemical and biophysical research communications

authors： Sandonà D,Tibaldo E,Volpe P

更新日期：2000-12-20 00:00:00

abstract：:Autophagy is a mechanism to digest cells' own components, and its importance in many physiological and pathological processes is being recognized. But the molecular mechanism that regulates autophagy is not understood in detail. In the present study, we found that cholesterol depletion induces macroautophagy. The cell...

journal_title：Biochemical and biophysical research communications

authors： Cheng J,Ohsaki Y,Tauchi-Sato K,Fujita A,Fujimoto T

更新日期：2006-12-08 00:00:00

abstract：:Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+, K+-ATPase activity of human ...

journal_title：Biochemical and biophysical research communications

authors： Fagoo M,Braquet P,Robin JP,Esanu A,Godfraind T

更新日期：1986-02-13 00:00:00

abstract：:Glycyrrhetinic acid (GA), a triterpene saponins, has been widely proven to have multiple medicinal properties. Our study aimed to figure out the protective effect of GA on acute lung injury (ALI) and the underlying mechanism. The LPS-induced ALI model mice were intratracheally administrated with 10 mg/kg LPS. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Wang K,Zhang Y,Cao Y,Shi Z,Lin Y,Chen Y,Zhao H,Liu X

更新日期：2020-11-19 00:00:00

abstract：:Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increas...

journal_title：Biochemical and biophysical research communications

authors： Nakadate Y,Kodera Y,Kitamura Y,Tachibana T,Tamura T,Koizumi F

更新日期：2013-11-29 00:00:00

abstract：:The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitut...

journal_title：Biochemical and biophysical research communications

authors： Lo SJ,Chen ML,Chien ML,Lee YH

更新日期：1986-03-13 00:00:00

abstract：:The aggregation of beta-amyloid peptides is very important for their neurotoxic effect; standardization of the aggregation grade is necessary for biological experiments. Measurement of aggregation with physicochemical methods is a difficult task. The present work revealed that FT-IR can be used for studying the aggreg...

journal_title：Biochemical and biophysical research communications

authors： Szabó Z,Klement E,Jost K,Zarándi M,Soós K,Penke B

更新日期：1999-11-19 00:00:00