Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint.

abstract：:HMGB1 is a conserved chromosomal protein composed of two DNA-binding domains and an acidic C-terminal tail. There were evidences suggesting that the C-terminal tail contributed to the DNA binding specificity of the N-terminal DNA-binding domains. However, the mechanism underlining this observation is largely unknown. ...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Zeng M,Wang W,Tang J

更新日期：2007-08-17 00:00:00

abstract：:Nicastrin is a recently discovered protein interacting with presenilins and the beta-amyloid precursor protein, the proteins playing key roles in Alzheimer's disease and which, when mutated, appear responsible for early-onset familial forms of Alzheimer's disease. Nicastrin was reported to modulate beta-amyloid produc...

journal_title：Biochemical and biophysical research communications

authors： Fergani A,Yu G,St George-Hyslop P,Checler F

更新日期：2001-12-07 00:00:00

abstract：:The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effec...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Wu K,Zhang L,Gao L,Chen S

更新日期：2018-02-26 00:00:00

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:Tamoxifen, a widely used nonsteroidal antiestrogen in the treatment of breast cancer, forms several metabolites. 4-Hydroxytamoxifen (4-OHTam), a metabolite found in the bloodstream, has much higher affinity for the estrogen receptor than tamoxifen itself. Oxidative activation of 4-OHTam induces DNA damage. DNA isolate...

journal_title：Biochemical and biophysical research communications

authors： Sharma M

更新日期：2000-06-24 00:00:00

abstract：:The role of hepatic nuclear factor 1α (HNF-1α) and its response element in the expression of glutathione S-transferase A1 (GSTA1) was investigated in hepatocytes cells injury induced by acetaminophen (APAP). Treatment of hepatocytes with C2-ceramide exacerbated cells injury with GSTA1 mRNA level reducing. Contrastingl...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Hao B,Muhammad I,Zhang Y,Yang Y,Shi C,Chang Y,Li R,Li C,Liu F

更新日期：2019-08-13 00:00:00

abstract：:The entire coding region of chlL, an essential chloroplast gene required for chlorophyll biosynthesis in the dark in Chlamydomonas reinhardtii, was precisely replaced by either the Klebsiella pneumoniae nifH (encoding the structural component of nitrogenase Fe protein) or the Escherichia coli uidA reporter gene encodi...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Day A,Dowson-Day M,Shen GF,Dixon R

更新日期：2005-04-15 00:00:00

abstract：:We examined the role of ras proteins in mitogenesis and proliferation of A10 smooth muscle cells. An assay was developed in which a dominant negative ras gene could be transiently expressed in vascular smooth muscle cells. As opposed to cells transfected with a control plasmid, those transfected with a dominant negati...

journal_title：Biochemical and biophysical research communications

authors： Irani K,Herzlinger S,Finkel T

更新日期：1994-08-15 00:00:00

abstract：:BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked d...

journal_title：Biochemical and biophysical research communications

authors： Zhao X,Sun Y,Yu H,Ye L,Zhang L,Lu J,Yuan Y,Qian G,Ge S

更新日期：2007-08-10 00:00:00

abstract：:The proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli is composed of two types of subunits, alpha and beta, organized as an alpha(2)beta(2) tetramer. The protein contains three recognizable domains, of which domain II is the transmembrane region of the molecule containing the pathway for pr...

journal_title：Biochemical and biophysical research communications

authors： Hou C,Bragg PD

更新日期：2001-01-19 00:00:00

abstract：:Parkinson's disease (PD) is neurodegenerative diseases caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. Stem cell therapy is one of the promising strategies in helping to cure PD. In the present study, human mesenchymal stem cells (MSCs) from eye conjunctiva stromal cells were differen...

journal_title：Biochemical and biophysical research communications

authors： Nadri S,Soleimani M,Mobarra Z,Amini S

更新日期：2008-12-12 00:00:00

abstract：:Leukocyte recruitment to lymph nodes or inflammatory sites is regulated by adhesion and activation. L-selectin (CD62L) is expressed on leukocytes and mediates tethering and rolling of leukocytes on endothelial cells. Upon stimulation L-selectin is down-regulated by proteolytic cleavage but the molecular mechanisms reg...

journal_title：Biochemical and biophysical research communications

authors： Phong MC,Gutwein P,Kadel S,Hexel K,Altevogt P,Linderkamp O,Brenner B

更新日期：2003-01-10 00:00:00

abstract：:The activation of vitamin D requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. However, it remains unclear which enzyme is relevant to vitamin D 25-hydroxylation. Recently, human CYP2R1 has been reported to be a potential candidate for a hepatic vitamin D 25-hydroxylase. Thus, vitamin D met...

journal_title：Biochemical and biophysical research communications

authors： Shinkyo R,Sakaki T,Kamakura M,Ohta M,Inouye K

更新日期：2004-11-05 00:00:00

abstract：:Our results show that in the intact normal animal cell mitochondrial ATP is directly connected to nuclear PARP-1 by way of a specific adenylate kinase enzymatic path. This mechanism is demonstrated in two models: (a) by its inhibition with a specific inhibitor of adenylate kinase, and (b) by disruption of ATP synthesi...

journal_title：Biochemical and biophysical research communications

authors： Kun E,Kirsten E,Hakam A,Bauer PI,Mendeleyev J

更新日期：2008-02-08 00:00:00

abstract：:The mouse gene locus Lsh/Ity/Bcg regulates macrophage activation for antimicrobial activity against intracellular pathogens. A candidate gene, designated natural resistance-associated macrophage protein gene (Nramp), recently isolated from a mouse pre-B cell cDNA library, encodes an integral membrane protein that has ...

journal_title：Biochemical and biophysical research communications

authors： Kishi F

更新日期：1994-11-15 00:00:00

abstract：:A direct radioimmunoassay for the rapid and accurate detection of human ANP from unextracted plasma is described. The sensitivity was approximately 50 pg/ml, respectively 2.5 pg/tube, the intra-assay variation 4%, and the inter-assay variation less than 12%. Rat ANP (1-28, 5-25, 5-27 and 5-28), oxydized and reduced hA...

journal_title：Biochemical and biophysical research communications

authors： Jüppner H,Brabant G,Kapteina U,Kirschner M,Klein H,Hesch RD

更新日期：1986-09-30 00:00:00

abstract：:ZinT (B1973), previously known as YodA, was originally characterised as a cadmium-induced periplasmic protein under the regulation of Fur and SoxS. Here we describe a decrease in zinT transcript in response to elevated copper concentrations and the zinc and copper dependent phenotype of a DeltazinT strain. Cadmium sen...

journal_title：Biochemical and biophysical research communications

authors： Kershaw CJ,Brown NL,Hobman JL

更新日期：2007-12-07 00:00:00

abstract：:We have compared the sequence and gene order of meta-cleavage pathway operons from alpha- and gamma-subgroups of the Proteobacteria with operons from Burkholderia sp. strain RP007 which belongs to the beta-subgroup of the Proteobacteria. Burkholderia RP007 was isolated for its ability to degrade phenanthrene and conta...

journal_title：Biochemical and biophysical research communications

authors： Laurie AD,Lloyd-Jones G

更新日期：1999-08-19 00:00:00

abstract：:Bovine embryonic stem-like cells (ES-like cells) appear to maintain a normal diploid karyotype indefinitely during culture in vitro and to express marker proteins that are characteristic of ES cells from mice, namely, alkaline phosphatase (AP), stage-specific embryonic antigen-1 (SSEA-1), STAT-3, and Oct 4. After prol...

journal_title：Biochemical and biophysical research communications

authors： Saito S,Sawai K,Ugai H,Moriyasu S,Minamihashi A,Yamamoto Y,Hirayama H,Kageyama S,Pan J,Murata T,Kobayashi Y,Obata Y,Yokoyama KK

更新日期：2003-09-12 00:00:00

abstract：:Most studies characterizing H-ras have been conducted in constitutively expressing cell lines. To explore the early interaction between H-ras p21 and signal transduction systems we have utilized an NIH3T3 fibroblast line transfected with a steroid inducible MMTV H-ras vector. Exposure to dexamethasone resulted in tran...

journal_title：Biochemical and biophysical research communications

authors： Murphy SK,Lindberg JB,Prussack DA

更新日期：1994-12-15 00:00:00

abstract：:The effect of secretory phospholipase A2 (sPLA2) on intracellular Ca2+ signaling in human astrocytoma cells was studied. sPLA2 increased cytosolic [Ca2+] ([Ca2+]c) in both Ca2+-containing and Ca2+-free medium, thus suggesting Ca2+ release from intracellular stores. The activation by sPLA2 of arachidonate release via c...

journal_title：Biochemical and biophysical research communications

authors： Hernández M,Barrero MJ,Alvarez J,Montero M,Sánchez Crespo M,Nieto ML

更新日期：1999-06-24 00:00:00

abstract：:An endogenous protein inhibits the PKA-phosphorylation of the DHP-binding calcium channel complex in vitro. The inhibitory activity could be reduced by a treatment with detergents or dithiothreitol. Further purification separates the inhibitory activity from the dihydropyridine-binding calcium channel complex. Both ac...

journal_title：Biochemical and biophysical research communications

authors： Woscholski R,Marmé D

更新日期：1992-08-14 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:Some properties of calmodulin(CaM)-binding proteins (CaMBPs) of the Ca(2+)-independent type were investigated in the synaptosomal membrane (SM) from rat brain using the [125I]CaM gel overlay method. When SM was prepared in the presence of Ca2+, Ca(2+)-independent CaM binding was decreased, whereas the Ca(2+)-dependent...

journal_title：Biochemical and biophysical research communications

authors： Natsukari N,Miwa A,Fujita M

更新日期：1992-03-16 00:00:00

abstract：:Helodermin is a peptide from the venom of the lizard Heloderma suspectum (Gila Monster) showing a high degree of sequence similarity with VIP, PHI and secretin in its N-terminal moiety. The present data support the presence of peptide(s) closely related to helodermin in the brain, gut and salivary glands of rat. In ou...

journal_title：Biochemical and biophysical research communications

authors： Robberecht P,De Graef J,Woussen MC,Vandermeers-Piret MC,Vandermeers A,De Neef P,Cauvin A,Yanaihara C,Yanaihara N,Christophe J

更新日期：1985-07-16 00:00:00

abstract：:Epidermal 7-ethoxyresorufin O-deethylase (EROD) activity was elevated greater than 100-fold within 4 to 7 h of topical treatment of SENCAR mice with 100 nmol dibenz[a,c]anthracene (DB[a,c]A). Treatment of skin with 2 micrograms of 12-O-tetradecanoylphorbol-13-acetate (TPA) 2 to 8 h prior to DB[a,c]A application suppre...

journal_title：Biochemical and biophysical research communications

authors： Reiners JJ Jr,Cantu AR,Schöller A

更新日期：1992-07-31 00:00:00

abstract：:Adeno-associated virus (AAV) capsids are composed of three proteins, VP1, VP2, and VP3. These capsid proteins have a common amino acid sequence, being expressed from different initiation codons on the same open reading frame. Although VP1 is necessary for viral infection, it is not essential for capsid formation. The ...

journal_title：Biochemical and biophysical research communications

authors： Hoque M,Shimizu N,Ishizu Ki,Yajima H,Arisaka F,Suzuki K,Watanabe H,Handa H

更新日期：1999-12-20 00:00:00

abstract：:In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote fibroblast proliferation, its pathophysiological effects in cardiac myocytes remain to be elucidated. In this study, we examined the biological effects of CTGF in ra...

journal_title：Biochemical and biophysical research communications

authors： Hayata N,Fujio Y,Yamamoto Y,Iwakura T,Obana M,Takai M,Mohri T,Nonen S,Maeda M,Azuma J

更新日期：2008-05-30 00:00:00

abstract：:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, ...

journal_title：Biochemical and biophysical research communications

authors： Naito M,Yusa K,Tsuruo T

更新日期：1989-02-15 00:00:00

abstract：:Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric carcinomas were examined to determine whether the FHIT gene is actually a frequent target for alteration during gastric carcinogenesis. To correlate DNA and RNA lesions of the FHIT gene with the effect on FHIT protein exp...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Kim WH,Kim HK,Woo KM,Nam HS,Kim HS,Kim JG,Cho MH

更新日期：2001-06-15 00:00:00