Analysis of tamoxifen-DNA adducts by high-performance liquid chromatography using postcolumn online photochemical activation.

abstract：:The surface receptor CUB domain-containing protein 1 (CDCP1) is highly expressed in several adenocarcinomas and speculated to participate in anchorage-independent cell survival and cell motility. Tyrosine kinase phosphorylation seems to be crucial for intracellular signaling of CDCP1. Lapatinib, a tyrosine kinase inhi...

journal_title：Biochemical and biophysical research communications

authors： Seidel J,Kunc K,Possinger K,Jehn C,Lüftner D

更新日期：2011-10-14 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a potent growth inhibitor and apoptosis inducer for most normal cells. However, tumor cells are commonly nevertheless sensitive to the tumor-suppressing effects of TGF-beta1. In this paper, we focus on the effects of TGF-beta1 on two important anti-apoptotic protein kina...

journal_title：Biochemical and biophysical research communications

authors： Xu Z,Ma DZ,Wang LY,Su JM,Zha XL

更新日期：2003-12-12 00:00:00

abstract：:Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in ...

journal_title：Biochemical and biophysical research communications

authors： Deleidi M,Yu C

更新日期：2016-05-06 00:00:00

abstract：:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated ...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

更新日期：1997-09-08 00:00:00

abstract：:Thymosin beta15 (Tbeta15) is a pleiotropic factor which exerts multiple roles in the development of nervous system and brain diseases. In this study, we found that the expressions of Tbeta15 mRNA and protein were substantially increased in several brain regions including hippocampal formation and cerebral cortex, foll...

journal_title：Biochemical and biophysical research communications

authors： Kim YW,Kim Y,Kim EH,Koh D,Sun W,Kim H

更新日期：2008-07-11 00:00:00

abstract：:Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B) has been of great interest in the field of oncology in recent years. The relationship between miRNAs and RPRD1B in gastric cancer (GC) has not been adequately reported. This study was designed to screen RPRD1B-targeted miRNAs and investigate its regulatory m...

journal_title：Biochemical and biophysical research communications

authors： Wenquan L,Hongqing X,Yuhua L,Lili W,Wang Z,Ziwei Z,Chuang W,Aizhen C,Xiaosong W,Bo W,Lin C

更新日期：2020-06-25 00:00:00

abstract：:The proto-oncogene Akt is a potent inhibitor of apoptosis, and it is activated in many human cancers. A number of recent studies have highlighted the importance of the inositol 1,4,5-trisphosphate (IP3) receptor(IP3R) in mediating calcium (Ca2+) transfer from the endoplasmic reticulum (ER) to the mitochondriain severa...

journal_title：Biochemical and biophysical research communications

authors： Marchi S,Rimessi A,Giorgi C,Baldini C,Ferroni L,Rizzuto R,Pinton P

更新日期：2008-10-31 00:00:00

abstract：:Efficient phagocytic clearance of apoptotic spermatogenic cells and residual bodies (RBs) by Sertoli cells (SCs) is crucial for functional mature spermatogenesis. However, little is known about the molecular mechanisms underlying this SCs function. Herein, we reported for the first time that SCs-expressing metastasis ...

journal_title：Biochemical and biophysical research communications

authors： Zhu CJ,Zhang S,Liang Y,Li W

更新日期：2014-03-14 00:00:00

abstract：:Rearrangement of the p53 gene is frequent in virus transformed cell lines and in chronic myelogenous leukemia. It is a rare event in solid tumours and has been reported only in osteosarcomas. In this study we have examined rearrangement of the p53 gene in human breast tumours. We found rearrangement in 35% of the pati...

journal_title：Biochemical and biophysical research communications

authors： Nayak BK,Patnaik S,Das BR

更新日期：1998-04-17 00:00:00

abstract：:Five different receptor subtypes for neuropeptide Y (NPY) have recently been cloned in mammals. We have discovered three distinct subtypes by PCR in the zebrafish, Danio rerio, and describe here one of these called zYc. The protein sequence identity is 46-51% to mammalian subtypes Y1, Y4 and Y6 and to zebrafish Ya, i....

journal_title：Biochemical and biophysical research communications

authors： Ringvall M,Berglund MM,Larhammar D

更新日期：1997-12-29 00:00:00

abstract：:We prepared three peptide fragments (fg.59-105, fg.63-105 and fg.64-105) by the BrCN cleavage of mutant lysozymes where Ile58, Trp62 and Trp63 were mutated to Met, respectively. From the analysis of formation of the disulfide bonds among Cys64, Cys76, Cys80 and Cys94 in the renaturation of each peptide fragment from t...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Ohkuri T,Imoto T

更新日期：1996-11-01 00:00:00

abstract：:Receptor-mediated responses to prostaglandins E1 and E2 are shown by electrophysiological methods in follicle-enclosed oocytes of Xenopus laevis. In voltage-clamped oocytes, prostaglandins E1 and E2 elicited an outward hyperpolarizing current. This outward membrane current was caused by an increase in K+ conductance. ...

journal_title：Biochemical and biophysical research communications

authors： Mori K,Oka S,Tani A,Ito S,Watanabe Y

更新日期：1989-08-15 00:00:00

abstract：:VMA1 translational product undergoes excision of a 50-kDa intervening segment (VDE: VMA1-derived endonuclease) and religation of the flanking regions to create a 69-kDa catalytic subunit of vacuolar membrane H+-ATPase. VDEs conjugated with polypeptides at both N- and C-terminal ends were expressed in Escherichia coli ...

journal_title：Biochemical and biophysical research communications

authors： Kawasaki M,Makino S,Matsuzawa H,Satow Y,Ohya Y,Anraku Y

更新日期：1996-05-24 00:00:00

abstract：:The major biological effects of glucocorticoids are thought to be initiated through changes in the expression of cellular genes. However, the mechanisms involved in the suppression of some gene products by glucocorticoids are not well defined. ID13 mouse fibroblast cells were treated with the synthetic glucocorticoid ...

journal_title：Biochemical and biophysical research communications

authors： Wallace AD,Wheeler TT,Young DA

更新日期：1997-03-17 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:Cytochrome c3 (Mr 26,000) has been characterized in Desulfovibrio vulgaris (Hildenborough) and its properties compared with polyhemic cytochromes c isolated from the same organism and from D. desulfuricans (Norway). It can be described as an octaheme cytochrome c3 constituted of two identical subunits. Absorption spec...

journal_title：Biochemical and biophysical research communications

authors： Loutfi M,Guerlesquin F,Bianco P,Haladjian J,Bruschi M

更新日期：1989-03-15 00:00:00

abstract：:A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profil...

journal_title：Biochemical and biophysical research communications

authors： Deb Majumdar I,Devanabanda A,Fox B,Schwartzman J,Cong H,Porco JA Jr,Weber HC

更新日期：2011-12-16 00:00:00

abstract：:IL-8 is a multi-functional pro-inflammatory chemokine, which is highly expressed in cancers, such as ER-negative breast cancer. The present study demonstrates the pervasive role of IL-8 in the malignant progression of ER-negative breast cancer. IL-8 siRNA inhibited proliferation and delayed the G1 to S cell cycle prog...

journal_title：Biochemical and biophysical research communications

authors： Shao N,Chen LH,Ye RY,Lin Y,Wang SM

更新日期：2013-02-15 00:00:00

abstract：:Many bacterial respiratory redox enzymes depend on the twin-arginine translocase (Tat) system for translocation and membrane insertion. Tat substrates contain an N-terminal twin-arginine (SRRxFLK) motif serving as the targeting signal towards the translocon. Many Tat substrates have a system specific chaperone - redox...

journal_title：Biochemical and biophysical research communications

authors： Cherak SJ,Turner RJ

更新日期：2015-10-02 00:00:00

abstract：:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

journal_title：Biochemical and biophysical research communications

authors： Staley J,Fiskum G,Moody TW

更新日期：1989-08-30 00:00:00

abstract：:Purified bovine adrenal P-45011 beta has been shown to catalyze conversions of cortisol to cortisone (11-oxidase activity), and 19-hydroxyandrostenedione to 19-oxoandrostenedione (19-oxidase activity), in the reconstituted system consisting of NADPH, NADPH:adrenodoxin reductase, and adrenodoxin. The turnover numbers (...

journal_title：Biochemical and biophysical research communications

authors： Suhara K,Takeda K,Katagiri M

更新日期：1986-04-14 00:00:00

abstract：:Anethole has been known to have chemopreventive activities as a suppressor of the incidence and multiplicity of both invasive and noninvasive carcinomas. The goal of this study was to understand the anti-metastatic effect of anethole through C-X-C chemokine receptor type 4 (CXCR4)/tumor suppressor phosphatase and tens...

journal_title：Biochemical and biophysical research communications

authors： Rhee YH,Chung PS,Kim SH,Ahn JC

更新日期：2014-05-16 00:00:00

abstract：:TopBP1 is involved in DNA replication and DNA damage checkpoint. Recent studies have demonstrated that TopBP1 is a direct positive effecter of ATR. However, it is not known how TopBP1 recognizes damaged DNA. Here, we show that TopBP1 formed nuclear foci after exposure to ionizing radiation, but such TopBP1 foci were a...

journal_title：Biochemical and biophysical research communications

authors： Morishima K,Sakamoto S,Kobayashi J,Izumi H,Suda T,Matsumoto Y,Tauchi H,Ide H,Komatsu K,Matsuura S

更新日期：2007-11-03 00:00:00

abstract：:The frequency of p73 mutation is low in hematologic malignancies as well as solid tumors. Aberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphoblastic leukemia (ALL). In the present study, we scanned for mutations in the exons 4, 5, 6, and 7 of p73 gene. Using PC...

journal_title：Biochemical and biophysical research communications

authors： Sahu GR,Das BR

更新日期：2005-02-18 00:00:00

abstract：:Reversible phosphorylation of RNA polymerase (RNAP) II's largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism. The CTD phosphatase, FCP1, catalyzes the dephosphorylation of RNAP II and is thought to play a major role in polymerase recycling. In this study, we isolated a novel phosphatase gene ...

journal_title：Biochemical and biophysical research communications

authors： Zheng H,Ji C,Gu S,Shi B,Wang J,Xie Y,Mao Y

更新日期：2005-06-17 00:00:00

abstract：:Dexamethasone (DEX) induces apoptosis in lymphocytes, while protecting some cancer cells from apoptosis, by a poorly understood mechanism. In this study, we examined the potential role of the forkhead transcription factor (FOXO3A) in DEX-induced apoptosis. Unphosphorylated FOXO3A, the active form of FOXO3A, can transl...

journal_title：Biochemical and biophysical research communications

authors： Ma J,Xie Y,Shi Y,Qin W,Zhao B,Jin Y

更新日期：2008-12-19 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:p66Shc plays a key role in oxidative stress-induced apoptosis. p66Shc gene expression is tissue-specific and controlled by promoter methylation. In T-cells p66Shc expression is induced by a variety of apoptotic stimuli. We have addressed the mechanisms regulating p66Shc expression in T-cells. We show that the increase...

journal_title：Biochemical and biophysical research communications

authors： Pezzicoli A,Ulivieri C,Capitani N,Ventura A,Pelicci P,Baldari CT

更新日期：2006-10-13 00:00:00

abstract：:Thrombomodulin (TM) is a cell-surface glycoprotein and a critical mediator of endothelial anticoagulant function. TM exists as both a chondroitin sulfate (CS) proteoglycan (PG) form and a non-PG form lacking a CS chain (α-TM); therefore, TM can be described as a part-time PG. Previously, we reported that α-TM bears an...

journal_title：Biochemical and biophysical research communications

authors： Izumikawa T,Kitagawa H

更新日期：2015-05-01 00:00:00

abstract：:Most proteins synthesized in cytoplasm target to mitochondria through sequences at their amino termini. However, a previous study suggests that the native carboxyl terminus of ISP6 might be critical of its specific delivery. Here we investigated the sequence directing ISP6 to yeast mitochondrial outer membrane. Unlike...

journal_title：Biochemical and biophysical research communications

authors： Cao W,Douglas MG

更新日期：1996-07-16 00:00:00