An endogenous membrane-bound protein inhibits the phosphorylation of the L-type calcium channel by the cAMP-dependent protein kinase.

abstract：:Proximal spinal muscular atrophy (SMA) results from loss of the survival motor neuron 1 (SMN1) gene, with retention of its nearly identical homolog, SMN2. There is a direct correlation between disease severity and SMN2 copy number. Mice do not have a Smn2 gene, and thus cannot naturally replicate the disorder. However...

journal_title：Biochemical and biophysical research communications

authors： Gogliotti RG,Hammond SM,Lutz C,Didonato CJ

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Reconstruction of respiratory epithelium is critical for the fabrication of bioengineered airway implants. Epithelial differentiation is typically achieved using bovine pituitary extract (BPE). Due to the xenogenic nature and undefined composition of BPE, an alternative for human clinical applications, dev...

journal_title：Biochemical and biophysical research communications

authors： Hintze JM,Tchoukalova YD,Sista R,Shah MK,Zhang N,Lott DG

更新日期：2018-09-18 00:00:00

abstract：:Invasion and metastasis are major causes of malignant tumor-associated mortality. The present study aimed to investigate the molecular events underlying inhibitory effect of N-benzylcantharidinamide, a novel synthetic analog of cantharidin, on matrix metalloproteinase-9 (MMP-9)-mediated invasion in highly metastatic h...

journal_title：Biochemical and biophysical research communications

authors： Lee JY,Chung TW,Choi HJ,Lee CH,Eun JS,Han YT,Choi JY,Kim SY,Han CW,Jeong HS,Ha KT

更新日期：2014-05-02 00:00:00

abstract：:A variety of different forms of cellular stress can cause protein misfolding and aggregation and proteotoxicity. The cytoprotective response to proteotoxicity is termed the integrated stress response and involves 4 distinct serine/threonine protein kinases that converge on the translation initiation factor eIF2α, resu...

journal_title：Biochemical and biophysical research communications

authors： McConkey DJ

更新日期：2017-01-15 00:00:00

abstract：:Skeletal muscle atrophy is an important clinical characteristic of chronic kidney disease (CKD); however, at present, the therapeutic approaches to muscle atrophy induced by CKD are still at an early stage of development. Resveratrol is used to attenuate muscle atrophy in other experimental models, but the effects on ...

journal_title：Biochemical and biophysical research communications

authors： Sun LJ,Sun YN,Chen SJ,Liu S,Jiang GR

更新日期：2017-05-20 00:00:00

abstract：:To relate specific effects on growth and transformation to activation of specific affinity states of the CCKA receptor stably expressed in CHO cells we compared responses to the CCK analogues JMV-180 and CCK8. CCK8 led to an inhibition of both cell proliferation and transformation. Effects on proliferation were indica...

journal_title：Biochemical and biophysical research communications

authors： Detjen K,Tseng MJ,Logsdon CD

更新日期：1995-08-04 00:00:00

abstract：:The EC(50) values for concentration-dependent stimulation of cAMP accumulation by CRF (1.3nM) and urocortin (1.0nM) were equivalent in human retinoblastoma Y79 cells. The time course and magnitude of CRF- and urocortin-induced CRF(1) receptor desensitization were similar. A significant 3-fold increase in GRK3, but not...

journal_title：Biochemical and biophysical research communications

authors： Dautzenberg FM,Wille S,Braun S,Hauger RL

更新日期：2002-11-01 00:00:00

abstract：:We investigated the influence of the relative abundance of insulin and IGF-1 receptors on cellular growth, by measuring the stimulation of c-fos expression and of H3-thymidine incorporation into DNA by insulin and IGF-1 in CHO cells overexpressing insulin Receptor (CHO-IR). We found that CHO-IR cells were resistant to...

journal_title：Biochemical and biophysical research communications

authors： Maggi D,Laurino C,Andraghetti G,Cordera R

更新日期：1994-11-30 00:00:00

abstract：:Using the primary culture of neonatal rat ventricular myocytes, synthesis and secretion of rat atrial natriuretic peptide (rANP) were studied. Ventricular myocytes in culture, although contained less amounts of cellular immunoreactive (IR)-rANP, secreted substantial amounts of IR-rANP at a rate comparable to that of a...

journal_title：Biochemical and biophysical research communications

authors： Matsubara H,Hirata Y,Yoshimi H,Takata S,Takagi Y,Yamane Y,Umeda Y,Nishikawa M,Inada M

更新日期：1987-11-13 00:00:00

abstract：:By using a subtraction-enhanced display technique, we identified a cDNA clone representing alpha-prothymosin, from rat hepatocellular carcinoma (HCC). alpha-Prothymosin has been reported to be involved in cell proliferation and regulated by c-myc gene in vitro. In the present study, we investigated the gene expression...

journal_title：Biochemical and biophysical research communications

authors： Wu CG,Boers W,Reitsma PR,van Deventer SJ,Chamuleau RA

更新日期：1997-03-27 00:00:00

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:Uromodulin (Tamm-Horsfall protein), the most abundant constituent of human urine, is synthesized exclusively in the kidney tubular epithelium and its amino acid sequence suggests a capacity for cell adhesion. We investigated adhesion between human uromodulin and neutrophils by allowing uromodulin, immobilized on micro...

journal_title：Biochemical and biophysical research communications

authors： Toma G,Bates JM Jr,Kumar S

更新日期：1994-04-15 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from normal adults secreted small amounts of human growth hormone (GH; 0.2-0.6 pg/10(5) cells/7 days culture) as measured by a highly sensitive enzyme immunoassay. Stimulation of PBMCs with phytohemagglutinin (PHA) consistently showed a 4-6 fold increase in GH secretion. Tran...

journal_title：Biochemical and biophysical research communications

authors： Hattori N,Shimatsu A,Sugita M,Kumagai S,Imura H

更新日期：1990-04-30 00:00:00

abstract：:Up to now, all reported Ca(2+)-regulated photoproteins, except for mnemiopsin, have been cloned and expressed in Escherichia coli. In this study, the cDNA for an isotype of mnemiopsin, from the ctenophore Mnemiopsis leidyi, has been cloned, sequenced, and functionally expressed. The full length cDNA encoding mnemiopsi...

journal_title：Biochemical and biophysical research communications

authors： Jafarian V,Sariri R,Hosseinkhani S,Aghamaali MR,Sajedi RH,Taghdir M,Hassannia S

更新日期：2011-09-23 00:00:00

abstract：:The spontaneous mutant, Wriggle Mouse Sagami (wri), is thought to be a model of hereditary hearing losses in humans. Here we report that the plasma membrane Ca(2+)-ATPase type 2 (PMCA2) gene is mutated in the wri mouse. A G-to-A transition was detected in wri, changing Glu-to-Lys within a conserved transmembrane domai...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Kitamura K

更新日期：1999-08-11 00:00:00

abstract：:EGF stimulates gene expression through a variety of signal transduction pathways that include the ras-Erk pathway. We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE. This element binds Sp1 family members and raises the possibility that the ra...

journal_title：Biochemical and biophysical research communications

authors： Merchant JL,Du M,Todisco A

更新日期：1999-01-19 00:00:00

abstract：:Class-I phosphoinositide 3-kinases (PI 3-kinases) are dual specificity enzymes that possess both lipid and protein kinase activity. While the best characterized property of this protein kinase is as an autokinase activity, there have also been reports it can phosphorylate exogenous substrates including peptides, IRS-1...

journal_title：Biochemical and biophysical research communications

authors： Foukas LC,Shepherd PR

更新日期：2004-06-25 00:00:00

abstract：:Homocysteine thiolactone is a highly reactive homocysteine derivative that can react easily with proteins. Protein homocysteinylation has been suggested as a possible mechanism underlying the pathological consequences of impaired homocysteine metabolism. Homocysteine inhibits key steps of angiogenesis and tumor invasi...

journal_title：Biochemical and biophysical research communications

authors： Martínez-Poveda B,Chavarría T,Sánchez-Jiménez F,Quesada AR,Medina MA

更新日期：2003-11-21 00:00:00

abstract：:Gastric cancer is one of the major causes of cancer death worldwide; however, the mechanism of carcinogenesis is complex and poorly understood. Long non-coding RNA HOTAIR (HOX transcript antisense RNA) recently emerged as a promoter of metastasis in various cancers including gastric cancer. Here we investigated the im...

journal_title：Biochemical and biophysical research communications

authors： Lee NK,Lee JH,Park CH,Yu D,Lee YC,Cheong JH,Noh SH,Lee SK

更新日期：2014-08-22 00:00:00

abstract：:The outward K+ current induced by step depolarization of freshly dispersed myocytes of guinea-pig taenia coli decreased about 80% upon treatment with 3 mM tetraethylammonium chloride (TEA). Isoproterenol (ISO, 2-5 microM) restored it to a large extent. This restoration did not occur in the presence of propranolol (2 m...

journal_title：Biochemical and biophysical research communications

authors： Fan SF,Wang S,Kao CY

更新日期：1994-05-30 00:00:00

abstract：:Extracellular calcium-deprivation inhibited the proliferation of BALB/c 3T3 cells and this inhibition correlated with a loss of protein kinase C activity from the particulate fraction. Addition of calcium induced proliferation of the cells with the DNA synthetic activity returning to the control rate at 18 hours follo...

journal_title：Biochemical and biophysical research communications

authors： Donnelly TE Jr,Sittler R,Scholar EM

更新日期：1985-01-31 00:00:00

abstract：:Pulmonary fibrosis is a progressive disorder whose molecular pathology is poorly understood. Here we developed an in-house cDNA microarray ("lung chip") originating from a lung-normalized cDNA library. By using this lung chip, we analyzed global gene expression in a murine model of bleomycin-induced fibrosis and selec...

journal_title：Biochemical and biophysical research communications

authors： Katsuma S,Nishi K,Tanigawara K,Ikawa H,Shiojima S,Takagaki K,Kaminishi Y,Suzuki Y,Hirasawa A,Ohgi T,Yano J,Murakami Y,Tsujimoto G

更新日期：2001-11-09 00:00:00

abstract：:An unusual C-terminal conformation has been detected in a synthetic decapeptide designed to analyze the stereochemistry of helix termination in polypeptides. The crystal structure of the decapeptide Boc-Leu-Aib-Val-Ala-Leu-Aib-Val-(D)Ala-(D)Leu-Aib-OMe reveals a helical segment spanning residues 1-7 and helix terminat...

journal_title：Biochemical and biophysical research communications

authors： Aravinda S,Shamala N,Pramanik A,Das C,Balaram P

更新日期：2000-07-14 00:00:00

abstract：:The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide bind...

journal_title：Biochemical and biophysical research communications

authors： Vihinen M,Nilsson L,Smith CI

更新日期：1994-12-15 00:00:00

abstract：:Administration of either D- or L-thyroxine (T4) significantly increased the glucocorticoid binding capacity of cytosol of the livers of adrenalectomized adult rats. Administration of up to 0.5 mg/100 g body wt. of L-T4 was more effective than that of D-T4, but higher doses (0.8-3 mg/100 g body wt.) of D-T4 increased t...

journal_title：Biochemical and biophysical research communications

authors： Naito K,Isohashi F,Tsukanaka K,Horiuchi M,Okamoto K,Matsunaga T,Sakamoto Y

更新日期：1985-06-14 00:00:00

abstract：:Mammalian cells contain two fatty acid synthesis pathways, the cytosolic FASI pathway, and the mitochondrial FASII pathway. The selection behind the conservation of the mitochondrial pathway is not completely understood, given the presence of the cytosolic FAS pathway. In this study, we show through heterologous gene ...

journal_title：Biochemical and biophysical research communications

authors： Parl A,Mitchell SL,Clay HB,Reiss S,Li Z,Murdock DG

更新日期：2013-11-15 00:00:00

abstract：:Pentoxyresorufin O-depentylase activity, mainly associated with phenobarbital-inducible cytochrome P450IIB1 (designated CYP2B1), was increased after a single treatment of pyridine (250 mg/kg, i.p.), and further increased by repeated treatments for 5 days. The catalytic activity and immunoreactive protein of CYP2B reco...

journal_title：Biochemical and biophysical research communications

authors： Park KS,Sohn DH,Veech RL,Song BJ

更新日期：1992-06-15 00:00:00

abstract：:Sleep deprivation (SD) has detrimental effects on the physiological function of the brain. However, the underlying mechanism remains elusive. In the present study, we investigated the expression of candidate plasticity-related gene 15 (cpg15), a neurotrophic gene, and its potential role in SD using a REM-SD mouse mode...

journal_title：Biochemical and biophysical research communications

authors： Li CJ,Li JJ,Jiang Y,Mu YW,Lu DX,Xiao ZY,Jiang HY,Zhao JJ,Chen XH

更新日期：2020-02-12 00:00:00

abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

journal_title：Biochemical and biophysical research communications

authors： Omkumar RV,Gaikwad AS,Ramasarma T

更新日期：1992-05-15 00:00:00

abstract：:Elevations in intracellular Ca(2+) ([Ca(2+)](i)) initiate insulin secretion from pancreatic beta-cells, but the secretory responses become rapidly desensitised to maintained elevations in [Ca(2+)](i). We have investigated the mechanisms underlying the Ca(2+) desensitization of insulin secretion using electrically perm...

journal_title：Biochemical and biophysical research communications

authors： Harris TE,Persaud SJ,Squires PE,Jones PM

更新日期：2000-04-21 00:00:00