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Uromodulin (Tamm-Horsfall protein) is a leukocyte adhesion molecule.

Abstract：

:Uromodulin (Tamm-Horsfall protein), the most abundant constituent of human urine, is synthesized exclusively in the kidney tubular epithelium and its amino acid sequence suggests a capacity for cell adhesion. We investigated adhesion between human uromodulin and neutrophils by allowing uromodulin, immobilized on microtiter plates, to interact with neutrophils. It was found that neutrophils attached to uromodulin in a saturable manner. The binding was inhibited by uromodulin in solution. It required metabolically active cells, was calcium sensitive and could be inhibited by arginine-glycine- aspartate-containing peptides in solution. These data suggest that uromodoulin can act as a specific ligand for neutrophils. This interaction is potentially important in leukocyte trafficking in the kidney and in the pathogenesis of interstitial nephritis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Toma G,Bates JM Jr,Kumar S

doi

10.1006/bbrc.1994.1445

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

275-82

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71445-8

journal_volume

200

pub_type

杂志文章

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