Stationary phase induced alterations in mycobacterial RNA polymerase assembly: A cue to its phenotypic resistance towards rifampicin.

abstract：:The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. Although Ser(10) and Thr...

journal_title：Biochemical and biophysical research communications

authors： Guan X,Chen L,Wang J,Geng H,Chu X,Zhang Q,Du L,De W

更新日期：2006-09-01 00:00:00

abstract：:The role of hepatic nuclear factor 1α (HNF-1α) and its response element in the expression of glutathione S-transferase A1 (GSTA1) was investigated in hepatocytes cells injury induced by acetaminophen (APAP). Treatment of hepatocytes with C2-ceramide exacerbated cells injury with GSTA1 mRNA level reducing. Contrastingl...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Hao B,Muhammad I,Zhang Y,Yang Y,Shi C,Chang Y,Li R,Li C,Liu F

更新日期：2019-08-13 00:00:00

abstract：:Choroidal neovascularization (CNV) is a type of wet age-related macular degeneration (AMD) which is a major cause of blindness in elder patients. Tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes tumor angiogenesis via upregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular e...

journal_title：Biochemical and biophysical research communications

authors： Ding D,Zhu M,Liu X,Jiang L,Xu J,Chen L,Liang J,Li L,Zhou T,Wang Y,Shi H,Yuan Y,Song E

更新日期：2018-09-18 00:00:00

abstract：:Epidermal growth factor receptor can interact directly with F-actin through an actin-binding domain. In the present study, a mutant EGFR, lacking a previously identified actin-binding domain (ABD 1), was still able to bind elements of the cytoskeleton. A second EGFR actin-binding domain (ABD 2) was identified in the r...

journal_title：Biochemical and biophysical research communications

authors： Song W,Wu J,Ge G,Lin Q

更新日期：2008-06-13 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00

abstract：:We have previously shown that the neurosteroid pregnenolone sulfate (PS) inhibits the capsaicin receptor-mediated current in rat dorsal root ganglion neurons. Here, we examined the effect of intradermal injection of PS into the rat hindpaw on capsaicin-induced nociception. Results revealed that PS co-injected with cap...

journal_title：Biochemical and biophysical research communications

authors： Chen SC,Liu BC,Chen CW,Wu FS

更新日期：2006-10-20 00:00:00

abstract：:Chitin oligosaccharides elicited chitinase activity in melon plants. Hexamer to nonamer were the most efficient elicitors: hexamer for maximal stimulation of colorimetrically assessed chitinase activity, heptamer for maximal stimulation of radiochemically assessed chitinase activity. Chitinase elicitation was a rapid ...

journal_title：Biochemical and biophysical research communications

authors： Roby D,Gadelle A,Toppan A

更新日期：1987-03-30 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in patients with PCOS...

journal_title：Biochemical and biophysical research communications

authors： Yu CJ,Liu X,Zhou ZY,Chen XJ,Meng YC,Gu HC,Xu JJ,Ding GL,Liu XM,Sheng JZ,Huang HF

更新日期：2020-02-17 00:00:00

abstract：:Xylan from Rhodymenia palmata binds to the cellobiohydrolase I from Trichoderma reesei (CBH I) or its core protein, inhibiting their activity. Adsorption onto microcrystalline cellulose (Avicel) is reduced approximately 30% for intact CBH I and nearly 50% for the core, whereas the effects with cellobiose are negligibl...

journal_title：Biochemical and biophysical research communications

authors： Abuja PM,Pilz I,Tomme P,Claeyssens M

更新日期：1989-12-15 00:00:00

abstract：:Cytochrome P450 enzymes (CYP enzymes) catalyse the initial step in biotransformation of xenobiotics like polycyclic aromatic hydrocarbons (PAHs). The marine polychaete Nereis virens has a high capacity for biotransformation of PAHs. In the present study, the complete cDNA sequences of two novel CYP genes isolated from...

journal_title：Biochemical and biophysical research communications

authors： Jørgensen A,Rasmussen LJ,Andersen O

更新日期：2005-10-28 00:00:00

abstract：:Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

journal_title：Biochemical and biophysical research communications

authors： Giannoni E,Raugei G,Chiarugi P,Ramponi G

更新日期：2006-09-22 00:00:00

abstract：:We report here on the cloning and functional characterization of human LAT1, a subunit of the amino acid transport system L. The hLAT1 cDNA, obtained from a human placental cDNA library, codes for a protein of 507 amino acids. When functionally expressed in mammalian cells together with the heavy chain of the rat 4F2 ...

journal_title：Biochemical and biophysical research communications

authors： Prasad PD,Wang H,Huang W,Kekuda R,Rajan DP,Leibach FH,Ganapathy V

更新日期：1999-02-16 00:00:00

abstract：:Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 microM with 4-h...

journal_title：Biochemical and biophysical research communications

authors： He Q,Khanna P,Srivastava S,van Kuijk FJ,Ansari NH

更新日期：1998-06-29 00:00:00

abstract：:In mammalian epidermis, alpha6beta4 integrin is expressed exclusively on the basal layer localized to the hemidesmosomes, where it interacts extracellularly with the laminin-5 ligand. During differentiation, loss of alpha6beta4 is associated with keratinocyte detachment from the basement membrane and upward migration....

journal_title：Biochemical and biophysical research communications

authors： Alt A,Gartsbein M,Ohba M,Kuroki T,Tennenbaum T

更新日期：2004-01-30 00:00:00

abstract：:In this paper we report the first comparative study of cold-adapted imidase (EC 3.5.2.2) from the fish (Oreochromis niloticus) liver and its thermophilic counterparts taken from pig liver and Escherichia coli (overexpressed recombinant hydantoinase from Agrobacterium radiobacter NRRL B1). Approximately 6000-fold purif...

journal_title：Biochemical and biophysical research communications

authors： Huang CY,Yang YS

更新日期：2003-12-12 00:00:00

abstract：:Gastric cancer (GC) is one of the most malignant tumors with high incidence and mortality worldwide, and the multidrug resistance (MDR) often results in chemotherapy failure in GC. DJ-1 has been well indicated to be associated with drug resistance in multiple cancers. However, the role of DJ-1 in the MDR of gastric ca...

journal_title：Biochemical and biophysical research communications

authors： Liu HY,Duan GL,Xu RY,Li XR,Xiao L,Zhao L,Ma ZX,Xu XW,Qiu LJ,Zhu ZM,Chen HP

更新日期：2019-10-29 00:00:00

abstract：:The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes. The treatment of cultured rat astrocytes with ET-1 increased stromelysin-1 mRNA levels, while stromelysin-2 and -3 mRNAs were not affected. Immunocytochemical observation...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Tanaka K

更新日期：2008-07-11 00:00:00

abstract：:We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mam...

journal_title：Biochemical and biophysical research communications

authors： Occhi G,Olivieri M,Rampazzo A,Danieli GA

更新日期：2004-05-21 00:00:00

abstract：:The active centre of NADPH-cytochrome P-450 reductase contains the lysine residue essential for catalytic activity. Chemical modification of epsilon-amino group of this lysine residue is the subject of the present study. To modify the epsilon-amino group, we have employed the periodate-oxidized NADP+ and NAD+ (o-NAD(P...

journal_title：Biochemical and biophysical research communications

authors： Slepneva IA,Weiner LM

更新日期：1988-09-15 00:00:00

abstract：:The Sf-9 insect cells infected with a recombinant baculovirus integrated with a cDNA encoding human monocyte chemoattractant protein-1 (MCP-1) produced three different MCP-1s, which were isolated by reverse-phase HPLC as 13kDa, 14kDa, and 15kDa bands on SDS-PAGE. The heterogeneity between these MCP-1s was ascribed to ...

journal_title：Biochemical and biophysical research communications

authors： Ishii K,Yamagami S,Tanaka H,Motoki M,Suwa Y,Endo N

更新日期：1995-01-26 00:00:00

abstract：:Activation of the extracellular calcium-sensing receptor (CaR) stimulates mitogen-activated protein kinases to upregulate the synthesis and secretion of parathyroid hormone related peptide (PTHrP) from cells expressing the CaR heterologously or endogenously. The current experiments demonstrate that this occurs because...

journal_title：Biochemical and biophysical research communications

authors： MacLeod RJ,Yano S,Chattopadhyay N,Brown EM

更新日期：2004-07-23 00:00:00

abstract：:Interleukin-18 (IL-18) is a proinflammatory cytokine. This protein has a role in regulating immune responses and exhibits significant anti-tumor activities. Epidermal growth factor (EGF) is an important growth factor that plays a central role in the regulation of cell cycle and differentiation. It was proposed that a ...

journal_title：Biochemical and biophysical research communications

authors： Lu JX,Peng Y,Meng ZF,Jin LQ,Lu YS,Guan MX

更新日期：2005-08-19 00:00:00

abstract：:One pathogenesis of the obesity-associated complications is that consistent with increased body fat mass, the elevation of adipose tissue-derived cytokines inflicts a low-grade chronic inflammation, which ultimately leads to metabolic disorders. Adipocytes and macrophages in visceral adipose (VA) have been confirmed t...

journal_title：Biochemical and biophysical research communications

authors： Yue GP,Du LR,Xia T,He XH,Qiu H,Xu LH,Chen XD,Feng SQ,Yang ZQ

更新日期：2005-08-05 00:00:00

abstract：:Heat stable enterotoxins (STs) are low molecular-weight peptides secreted by enterotoxigenic bacteria. One type of these enterotoxins (STa) induces intestinal secretion leading to acute diarrhea by binding to a membrane form of guanylate cyclase. We have isolated a cDNA from a human colonic cell line, T84, encoding fo...

journal_title：Biochemical and biophysical research communications

authors： Singh S,Singh G,Heim JM,Gerzer R

更新日期：1991-09-30 00:00:00

abstract：:Treatment of RGCs with insulin or C2 ceramide alone increased survival rate by 30%. Adding both insulin and C2 ceramide increased survival rate by 80%. Protein phosphatase 2A (PP2A) inhibitor okadaic acid (OA) eliminated the effect of C2 ceramide, but not that of insulin. Protein kinase inhibitor K252a decreased the e...

journal_title：Biochemical and biophysical research communications

authors： Ito M

更新日期：2003-02-07 00:00:00

abstract：:Computer-based approaches identified PTE2 as a candidate human peroxisomal acyl-CoA thioesterase gene. The PTE2 gene product is highly similar to the rat cytosolic and mitochondrial thioesterases, CTE1 and MTE1, respectively, and terminates in a tripeptide sequence, serine-lysine-valine(COOH), that resembles the conse...

journal_title：Biochemical and biophysical research communications

authors： Jones JM,Gould SJ

更新日期：2000-08-18 00:00:00

abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Suzuki N

更新日期：2014-10-03 00:00:00

abstract：:Using the patch-clamp technique, we determined that 1-15 mM extracellular acetylcholine reduced whole-cell n-type K+ currents in human peripheral blood lymphocytes and accelerated their inactivation. The percentage increase in K+ channel inactivation rate and the degree of drug induced block were independent of membra...

journal_title：Biochemical and biophysical research communications

authors： Gáspár R Jr,Varga Z,Bene L,Marcheselli F,Pieri C,Damjanovich S

更新日期：1996-09-13 00:00:00

abstract：:We have obtained the optimized geometrical structure of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium dipolar ion and investigated its geometric and electric changes during decarboxylation process by the MNDO-PM3 method, a molecular orbital method. The salient features of the optimized structure are that the dih...

journal_title：Biochemical and biophysical research communications

authors： Nakajima Y,Sakagishi Y,Shiibashi M,Suzuki Y,Kato H

更新日期：1993-08-31 00:00:00

abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

journal_title：Biochemical and biophysical research communications

authors： Omkumar RV,Gaikwad AS,Ramasarma T

更新日期：1992-05-15 00:00:00