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Inhibition of TRAF6 alleviates choroidal neovascularization in vivo.

Abstract：

:Choroidal neovascularization (CNV) is a type of wet age-related macular degeneration (AMD) which is a major cause of blindness in elder patients. Tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes tumor angiogenesis via upregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). Additionally, TRAF6 facilitates the inflammatory response in macrophages and microglia. Here, using mouse laser-induced CNV model and TRAF6 siRNA, the study shows that TRAF6 is a critical player in CNV. The expression of TRAF6, HIF-1α, and VEGF increased in the model. TFAF6 siRNA intravitreal (IVT) injection inhibited CNV formation, as well as expression of HIF-1α and VEGF, activation of macrophages and microglia. Together, our data suggest that TFAF6 inhibition reduces CNV formation via down-regulating expression of HIF-1α and VEGF and activation of macrophages and microglia, demonstrating the unique advantages of TRAF6 inhibition in the alleviation of AMD.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ding D,Zhu M,Liu X,Jiang L,Xu J,Chen L,Liang J,Li L,Zhou T,Wang Y,Shi H,Yuan Y,Song E

doi

10.1016/j.bbrc.2018.08.034

subject

Has Abstract

pub_date

2018-09-18 00:00:00

pages

2742-2748

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31714-5

journal_volume

503

pub_type

杂志文章

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